INvestigations In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation (CORT)
INvestigations In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation (CORT)
批准号:
9767022
负责人:
Kenneth G Saag
金额:
$128.13万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-09-20 至 2022-08-31
关键词:
AbsenteeismAddressAdenosine MonophosphateAdultAdvisory CommitteesAffectAlabamaBasic ScienceBiological AssayBiological MarkersBiometryCaliforniaChronic DiseaseChronic Kidney FailureClinical ResearchComorbidityComparative StudyCross-Over StudiesDevelopmentDisease ProgressionDoctor of PhilosophyElderlyEnvironmental Risk FactorEpidemicEpidemiologyFlareFosteringFrequenciesGenesGeneticGenetic TranslationGoalsGoutHealthcareHealthcare SystemsHyperuricemiaIncidenceInflammatoryInflammatory ArthritisInfrastructureInstitutionInterdisciplinary StudyInternationalInternetInvestigationKidney DiseasesKnowledgeLaboratoriesLeukocytesLinkMediatingMedicalMetabolic syndromeMethodsMissionModernizationMolecularMolecular ProfilingNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNephrologyOutcomePatientsPersonsPharmaceutical PreparationsPopulationPremature MortalityPrevalenceProductivityProtein KinasePublicationsQuality of lifeRecordsRenal functionReportingResearchResearch MethodologyResearch Project GrantsResearch SupportResourcesRheumatologySerumTechniquesTrainingTranslational ResearchUniversitiesUrateWorkaging populationbaseclinically relevantdesignexperiencefunctional genomicsgene environment interactiongenome wide association studyhealth care service utilizationimprovedinnovationmembermenmetabolomicsmultidisciplinarynovelperipheral bloodpersonalized careprecision medicineproductivity losssoundsuccesstooltranslational impacttranslational research programtranslational scientisturate transporter
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Gout impacts around 4% of the U.S. adult population and is the most common form of inflammatory arthritis in
men. The incidence of gout is increasing worldwide and may be as high as 9% in the elderly. Gout is a
significant burden on the healthcare system, and is associated with both decreased work productivity and
quality of life. With the ever-increasing impact of gout and its associated comorbidities on the population,
investigation of novel translational mechanisms mediating gout flares as well as approaches to improving gout
and hyperuricemia outcomes comprise an unmet and urgent medical need. Our multi-disciplinary
INvestigationS In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation
(CORT) includes 4 research projects and an Administrative Core focused on the theme, “Gout,
Hyperuricemia, and Associated Comorbidities”. CORT projects will include studies to: determine if
innovative peripheral blood leukocyte adenosine monophosphate-activated protein kinase (AMPK) activity
metabolomics have promise as gout flare biomarkers independent of serum urate (Project 1), examine the
influence of key gene-environment interactions within an internet case-crossover study of gout flares (Project
2), unravel the functional genomics of urate transporters genes identified in previously reported genome wide
association studies (Project 3), and investigate the mechanism of urate lowering therapy on renal function
within the soon to begin comparative study of gout therapies (VA STOP-GOUT) (Project 4). Projects range
from basic research translation of underlying genetics and relevant inflammatory pathobiology of gout, to
understanding mechanisms of CKD progression in gout, and translation of genetic interaction with
environmental factors and medications to precision medicine. Our INSIGHT CORT aims to:
(1) Conduct four outstanding, innovative, and synergistic translational research projects drawing on the unique
strengths of multidisciplinary research teams at our three major centers: University of Alabama at Birmingham,
Harvard University, and University of California San Diego. (2) Foster the development of pilot and feasibility
projects and the development and application of new translational methods to research in gout and
hyperuricemia and their associated major comorbidities, particularly chronic kidney disease and metabolic
syndrome. (3) Promote training of translational investigators in current methods of research applicable to gout
and hyperuricemia through enrichment activities overseen by our Administrative Core.
The INSIGHT CORT reflects a focused, relevant, multi-disciplinary translational research program at UAB and
partner institutions. The INSIGHT CORT has assembled an outstanding scientific team and is uniquely
prepared and strongly committed to scientific rigor, innovation, and development of new knowledge and
translational techniques clinically relevant to the mission NIAMS.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAM
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批准号:9892162
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项目类别:
-
资助金额:$104.32万
-
财政年份:2019
-
负责人:Kenneth G Saag
-
依托单位:
DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAM
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批准号:10407080
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项目类别:
-
资助金额:$104.32万
-
财政年份:2019
-
负责人:Kenneth G Saag
-
依托单位:
DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAM
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批准号:10641020
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项目类别:
-
资助金额:$104.32万
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财政年份:2019
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负责人:Kenneth G Saag
-
依托单位:
DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAM
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批准号:9926326
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项目类别:
-
资助金额:$104.32万
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财政年份:2019
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负责人:Kenneth G Saag
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依托单位:
NRSA Training Core
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批准号:10152712
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项目类别:
-
资助金额:$75.09万
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财政年份:2019
-
负责人:Kenneth G Saag
-
依托单位:
NRSA Training Core
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批准号:10627923
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项目类别:
-
资助金额:$69.56万
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财政年份:2019
-
负责人:Kenneth G Saag
-
依托单位:
NRSA Training Core
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批准号:10406883
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项目类别:
-
资助金额:$80.0万
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财政年份:2019
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负责人:Kenneth G Saag
-
依托单位:
NRSA Training Core
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批准号:9926328
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项目类别:
-
资助金额:$74.25万
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财政年份:2019
-
负责人:Kenneth G Saag
-
依托单位:
NRSA Training Core
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批准号:9892177
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项目类别:
-
资助金额:$73.44万
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财政年份:2019
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负责人:Kenneth G Saag
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依托单位:
UAB Center for Clinical and Translational Sciences (CCTS)
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批准号:9128786
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项目类别:
-
资助金额:$55.23万
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财政年份:2015
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负责人:Kenneth G Saag
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依托单位:
UAB Center for Clinical and Translational Science (CCTS)
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批准号:9085538
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项目类别:
-
资助金额:$54.36万
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财政年份:2015
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负责人:Kenneth G Saag
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依托单位:
Genetic Influence and Orthodontic Outcomes Associated with Short Root Anomaly in Minority Populations
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批准号:9380259
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项目类别:
-
资助金额:$14.37万
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财政年份:2015
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负责人:Kenneth G Saag
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依托单位:
UAB K12 in Patient Centered Outcomes Research
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批准号:8703275
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项目类别:
-
资助金额:$52.44万
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财政年份:2014
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负责人:Kenneth G Saag
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依托单位:
Effectiveness of DiscontinuinG bisphosphonatEs Study (EDGE)
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批准号:8652436
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项目类别:
-
资助金额:$31.74万
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财政年份:2013
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负责人:Kenneth G Saag
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依托单位:
Effectiveness of DiscontinuinG bisphosphonatEs Study (EDGE)
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批准号:8501962
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项目类别:
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资助金额:$32.97万
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财政年份:2013
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负责人:Kenneth G Saag
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依托单位:
The Effects of Urate Lowering Therapy on Inflammation, Endothelial function, and
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批准号:8525345
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项目类别:
-
资助金额:$32.01万
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财政年份:2013
-
负责人:Kenneth G Saag
-
依托单位:
INvestigations In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation (CORT)
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批准号:9902085
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项目类别:
-
资助金额:$96.11万
-
财政年份:2012
-
负责人:Kenneth G Saag
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依托单位:
UAB K12 in Patient Centered Outcomes Research
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批准号:8416111
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项目类别:
-
资助金额:$45.0万
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财政年份:2012
-
负责人:Kenneth G Saag
-
依托单位:
Administrative Core
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批准号:10017001
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项目类别:
-
资助金额:$27.19万
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财政年份:2012
-
负责人:Kenneth G Saag
-
依托单位:
UAB K12 in Patient Centered Outcomes Research
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批准号:8501347
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项目类别:
-
资助金额:$45.0万
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财政年份:2012
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负责人:Kenneth G Saag
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依托单位:
海外基金