Administrative Core

项目摘要 痛风影响约4%的美国成年人口，是美国最常见的炎性关节炎。 男人痛风的发病率在全球范围内不断增加，在老年人中可能高达9%。痛风是一 对医疗保健系统造成重大负担，并与工作效率降低和 生活质量随着痛风及其相关合并症对人群的影响不断增加， 研究新的翻译机制介导痛风发作以及改善痛风的方法 并且高尿酸血症的结果包括未满足的和紧急的医疗需求。行政核心是 负责集中精力研究痛风、高尿酸血症和合并症 （INSIGHT）研究翻译中心（CORT）的4个研究项目。行政核心将 促进我们的主题“痛风、高尿酸血症和相关合并症”的知识翻译， 研究人员、临床医生、患者、受训人员和政策制定者。INSIGHT CORT的目标是改善 通过科学的应用，减轻痛风和高尿酸血症的社会负担 严格的，国家的最先进的方法，以临床重要的转化研究问题。的 行政核心旨在： (1)为INSIGHT项目提供监督管理、方法和统计支持 CORT;（2）利用专业的独特优势开展杰出的创新研究项目 亚拉巴马大学伯明翰分校（UAB）、哈佛大学医学院附属 马萨诸塞州总医院（MGH）和布里格姆妇女医院（BWH），以及 加州圣地亚哥（UCSD），使用最先进的工具，从流变学，遗传学，统计学， （3）促进试点项目和可行性项目的发展， 开发和应用新的评价，分析和翻译方法，以研究痛风和 高尿酸血症;（4）促进临床研究人员在最新的翻译方法的培训 通过富集计划进行适用于痛风和高尿酸血症的研究和评估;（5）保持 并扩大UAB痛风流变学，关节炎数据库和储存库，一个资源，将服务于CORT 本申请中提出的项目;（6）协调与咨询委员会的互动。 为了实现INSIGHT CORT的总体目标并完成其目标， 将对该项目进行日常的科学监督它将协调CORT的活动， 促进互动和合作，促进科学发展，进行持续评估 正在进行的CORT计划，并为CORT制定战略议程。

PROJECT SUMMARY Gout impacts around 4% of the U.S. adult population and is the most common form of inflammatory arthritis in men. The incidence of gout is increasing worldwide and may be as high as 9% in the elderly. Gout is a significant burden on the healthcare system, and is associated with both decreased work productivity and quality of life. With the ever-increasing impact of gout and its associated comorbidities on the population, investigation of novel translational mechanisms mediating gout flares as well as approaches to improving gout and hyperuricemia outcomes comprise an unmet and urgent medical need. The Administrative Core is responsible for the focusing the efforts our INvestigationS In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation (CORT) on 4 research projects. The Administrative Core will facilitate knowledge translation of our theme, “Gout, Hyperuricemia, and Associated Comorbidities” to researchers, clinicians, patients, trainees, and policy makers. The goal for the INSIGHT CORT is to improve the healthcare of patients and reduce the societal burden of gout and hyperuricemia by applying scientifically rigorous, state-of-the-art methodology to clinically important translational research questions. The Administrative Core aims to: (1) Provide oversight management, methodologic, and statistical support for projects comprising the INSIGHT CORT; (2) Conduct outstanding, innovative research projects drawing on unique strengths of the major partners at University of Alabama at Birmingham (UAB), Harvard University Medical School-affiliated Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH), and University of California San Diego (UCSD), using state-of-the-art tools from rheumatology, genetics, statistics, epidemiology, and outcomes research; (3) Foster the development of pilot and feasibility projects and the development and application of new evaluative, analytic, and translational methods to research in gout and hyperuricemia; (4) Promote the training of clinical investigators in the most current methods of translational research and evaluation applicable to gout and hyperuricemia through an enrichment program; (5) Maintain and enlarge the UAB Gout Rheumatology, Arthritis Database and Repository, a resource that will serve CORT projects proposed in this application; (6) Coordinate interactions with the Advisory Committees. To achieve the overall goal of the INSIGHT CORT and to accomplish its objectives, the Administrative Core will provide day-to-day scientific oversight of the program. It will coordinate the CORT's activities while facilitating interactions and collaborations, promoting scientific development, performing continuous evaluation of ongoing CORT programs, and setting the strategic agenda for the CORT.