Long-term sequelae of early life pesticide exposure in the CHAMACOS birth cohort

CHAMACOS 出生队列中生命早期接触农药的长期后遗症

• 批准号: 9899747
• 负责人: Brenda Eskenazi
• 金额: $ 50万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899747
• 关键词: 16 year old; 18 year old; Accounting; Address; Adolescence; Adult; Age; Agriculture; Attention; Barker Hypothesis; Biological; Biological Assay; Biological Markers; Birth; Blood; Blood Cells; Blood specimen; Brain; California; Cardiovascular Diseases; Cardiovascular system; Chemical Exposure; Chemicals; Child; Childhood; Clinical Chemistry; Cohort Studies; Collection; Communities; DNA Methylation; Data; Data Collection; Data Reporting; Development; Diabetes Mellitus; Enrollment; Environmental Exposure; Environmental Policy; Epigenetic Process; Exposure to; Fasting; Fatty Liver; Flame Retardants; Functional Magnetic Resonance Imaging; Generations; Genetic; Growth; Health; Health Policy; Hispanics; Hydroxyl Radical; Hypertension; Immigrant; Individual; Laboratories; Learning; Length; Life; Liver diseases; Longterm Follow-up; Low income; Lung diseases; Measures; Metabolic; Metabolic Diseases; Metabolic syndrome; Methodology; Methods; Mexican; Mexican Americans; Modeling; Modification; Molecular; Monitor; Mothers; National Children' s Study; Near-Infrared Spectroscopy; Neonatal; Neuropsychology; Obesity; Organophosphates; Outcome; Outcome Measure; Overweight; Paper; Participant; Pervasive Development Disorder; Pesticides; Phase; Population; Positioning Attribute; Pregnancy; Process; Protocols documentation; Publishing; Questionnaires; Reflex action; Reporting; Respiratory Signs and Symptoms; Respiratory physiology; Salinas Valley; Sampling; School-Age Population; Ships; Solid; Specimen; Spirometry; Symptoms; Testing; Time; Trust; Umbilical Cord Blood; United States National Institutes of Health; Universities; Urine; Youth; agricultural community; agricultural pesticide; biobank; bisphenol A; cohort; data management; early childhood; early life exposure; emerging adult; executive function; experience; farm worker; follow-up; health assessment; high risk; high risk population; in utero; insight; instrument; multidisciplinary; neurobehavioral; neurodevelopment; neuroimaging; novel; obesity risk; perinatal outcomes; pesticide exposure; phthalates; pollutant; prenatal; prenatal exposure; respiratory; respiratory health; season of birth; sex; tool

ABSTRACT The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) is a longitudinal birth cohort of ~600 primarily first-generation Mexican American children living in the agricultural Salinas Valley, California. CHAMACOS was formed with the same intent as ECHO: to examine the association of early life environmental exposures with birth outcomes, neurodevelopment, respiratory health, and obesity. We have followed children from in utero through adolescence and we now propose to follow them into adulthood. Over the past 17 years, we have developed effective strategies to enroll, track, and retain study participants in this low-income Latino population; we have succeeded in collecting high quality data on all four endpoints of focus for ECHO; we have collected, processed, shipped, and stored over 150,000 varied biological and environmental samples; we have measured over 100 chemical exposures; we have helped develop and test sophisticated and novel exposure, genetic, and epigenetic laboratory assays; and we have developed a solid community-university partnership, earning the trust of participants and community stakeholders. Thus, CHAMACOS could serve as a model birth cohort for ECHO, rare in its length and breadth of assessment of children from birth to adulthood, offering valuable methodologies, lessons learned, and opportunities to the larger ECHO consortium. In addition, CHAMACOS contributes to ECHO a select, high-risk population of Latino children in a farmworker community . As 60% of this cohort is overweight or obese, we also offer data on children at high risk of metabolic, cardiovascular, and liver disease. Because the CHAMACOS children are approaching adulthood, we are uniquely positioned to examine the early origins of adult disease and address important gaps in the relationship between early life exposures and multiple health endpoints. We have reported that in utero organophosphate pesticide (OP) exposure is associated with poorer attention and executive function, lower IQ, respiratory symptoms, and poorer lung function at school-age. In the UG3 phase, we aim to test new methods that will expand our understanding of these relationships and contribute cutting-edge methodologies to ECHO. We propose to: 1) examine a newly-studied epigenetic modification, hydroxyl-methylcytosine (5-hmC) – a potentially strong candidate for understanding the molecular mechanisms underlying effects on neurodevelopment; and 2) apply near infrared spectroscopy (fNIRs) for functional neuroimaging – an inexpensive and convenient alternative to functional MRI. In the UH3 phase, we propose to follow-up participants at age 18 and 21 to assess the effects of in utero and early childhood exposure to agricultural pesticides on: 1) neurobehavioral endpoints; 2) respiratory symptoms and function; and 3) body mass and related metabolic and cardiovascular conditions. This valuable cohort has the potential to add rich data, validated protocols, and practical experience to the ECHO consortium, while also answering vital questions about the long-term sequelae of prenatal and early life exposure to pesticides on adult health.

抽象的 萨利纳斯（Chamacos）母亲和子女的健康评估中心是纵向 〜600个主要第一代墨西哥裔美国儿童的生日队列居住在农业萨利纳斯 加利福尼亚山谷。 Chamacos的形成与Echo相同：检查早期的关联 通过出生结果，神经发育，呼吸健康和肥胖的生活环境暴露。 我们有 跟随子宫里的孩子穿过青少年，我们现在建议跟随他们成年。 在过去的17年中，我们制定了有效的策略来注册，跟踪和保留研究 这个低收入拉丁裔人口的参与者；我们已经成功地收集了这四个的高质量数据 回声的重点端点；我们已经收集，处理，运输和存储了150,000多种 生物和环境样品；我们测量了100多次化学暴露；我们提供了帮助 开发和测试复杂和新颖的暴露，遗传和表观遗传学实验室测定；我们有 建立了扎实的社区 - 大学合作伙伴关系，赢得了参与者和社区的信任 利益相关者。那就是查索斯可以用作Echo的模型出生队列，其长度和宽度很少 从出生到成年的儿童评估， 提供有价值的方法，学习的教训以及 较大的回声财团的机会。此外，Chamacos贡献了 回应选择高风险 农场工人社区中的拉丁裔儿童人口 。由于该队列的60％超重或肥胖，我们也 提供有关具有代谢，心血管和肝病的高风险的儿童的数据。 因为 这 查索斯 孩子们正在成年，我们 在检查成人疾病的早期起源方面是独特的 并解决早期生活暴露与多个健康终点之间关系的重要差距。 我们报告说，在子宫磷酸子宫磷酸盐（OP）中，暴露与较差有关 注意力和执行功能，下智商，呼吸道症状和肺部较差的肺部功能。 UG3阶段，我们旨在测试新方法，以扩大我们对这些关系的理解，并 为回声贡献尖端方法。我们建议：1）检查新研究的表观遗传学 修饰，羟基环霉素（5-HMC） - 一种可能了解分子的强大候选者 对神经发育的影响的机制； 2）在红外光谱（FNIRS）附近应用 功能性神经影像学 - 功能性MRI的廉价且方便的替代方案。在UH3阶段，我们 提议在18岁和21岁时跟进参与者评估子宫内和幼儿的影响 接触农业农药：1）神经行为终点； 2）呼吸道症状和功能； 3）体重以及相关的代谢和心血管疾病。该值队列具有潜力 在回声联盟中添加丰富的数据，经过验证的协议和实践经验，同时还回答 关于成人健康中农药的产前和早期生命暴露于农药的长期后遗症的重要问题。