Neuroscience of Cognitive Aging

 描述（由申请人提供）：现代神经科学有可能为满足当前和未来与人口老龄化相关的社会挑战做出重大贡献。为了保持老年人的健康和自主性，了解衰老过程的基本机制是最紧迫的。解读健康大脑在整个生命周期中的神经结构和功能变化对于开发诊断、预防、治疗和保健的新方法至关重要。根据新获得的关于衰老基本机制的知识，可以制定适当的培训措施和干预措施。因此，现在比以往任何时候都更迫切需要为这一研究领域注入新的、具有高度创造力的年轻科学家。因此，此T32培训应用程序的目的是开发一个高度多样化但综合的计划 神经科学研究的目的是了解衰老大脑的生物学基础，因为它涉及到整个人类大脑衰老范围内的认知。为了实现这一目标，我们建议以协同和合作的方式汇集加州大学戴维斯分校优秀的神经科学研究和教育资源，以培养新的博士后学生（每年3名- 3年培训计划，5年内共6名学员）。这些学员将作为转化神经科学研究认知老化的催化剂，该计划将通过汇集不同但免费的教师和实验室，并产生新资助的研究，以促进科学，以改善人类健康，为加州大学戴维斯分校老龄化研究社区带来附加值。

 DESCRIPTION (provided by applicant): Modern neuroscience has the potential to significantly contribute to meeting current and future social challenges related to the advancing age of the population. In order to maintain health and autonomy in old age, understanding of the basic mechanisms of aging processes are of the utmost urgency. Deciphering the changes in neural structure and function of the healthy brain throughout the entire life span is essential for developing new approaches for diagnostics, prevention, therapy and health care. Based on newly acquired knowledge about the basic mechanisms of aging appropriate training measures and interventions can be developed. As a consequence, the need for the infusion of new and highly creative young scientists into this area of research has never been more acute. The aim of this T32 training application, therefore, is to develop a highly diverse, but integrated program of neuroscience research that aims to understand the biological underpinnings of the aging brain as it relates to cognition across the spectrum of human brain aging. To accomplish this goal, we propose to bring together the outstanding neuroscience research and education resources of UC Davis in a synergistic and collaborative manner to train new post-doctoral students (3 per year - 3-year training programs, total of 6 trainees over 5 years). These trainees will serve as catalysts for translational neuroscience research on cognitive aging, and this program will bring added value to the UC Davis aging research community by bringing together disparate but complimentary faculty and laboratories and generating newly funded research related to advancing science to improve human health.