UC Davis Alzheimer's Disease Core Center

项目总结/摘要 非裔美国人（AA）和拉丁美洲人是美国最大的两个少数民族，是否会影响到系统性 阿尔茨海默病和相关疾病（ADRD）以及其他一些共病的医疗 疾病（如高血压、糖尿病等）。基于人口的研究表明， 少数民族的残疾率较高，因此目标1将审查在以下方面是否存在差异： 与非西班牙裔相比，AA和拉丁裔的工具性日常生活活动（IADL）困难 白人了解、预防和改善潜在的健康差距是一项主要的公共卫生优先事项 因为较差的功能结果会转化为生活质量的差异和更大的经济负担。 目标2将检查与功能性能力相关的关键因素是否存在差异 跨群体。无论IADL残疾的总体水平是否存在差异， 是不同的影响因素（例如，认知、身体功能和医学共病）。本研究 将解决对潜在差异和功能结果贡献者的知识方面的重要差距， 这对制定有效的公共卫生政策和定制干预措施具有重要意义。这 补助金可让陈医生减轻临床工作的责任，并增加其专注研究的工作 时间，这将有助于实现她的长期职业目标，发展一个独立的研究计划 在与少数民族之间的差距有关的ADRD中。这一补充也将提供一个指导研究 在UCD阿尔茨海默病中心的经验，将进一步发展她在临床研究的经验 方法和生产同行评审的关于ADRD的科学出版物，这将提高她现有的 少数民族认知老化的知识基础。

PROJECT SUMMARY/ABSTRACT African Americans (AA) and Latinos, the two largest minority groups in the U.S., are disproportionality affected by Alzheimer's disease and related disorders (ADRD) as well as a number of other comorbid medical conditions (e.g. hypertension, diabetes, etc.). There is evidence from population-based studies that general rates of disability are higher among minorities, and thus Aim 1 will examine whether there are disparities in instrumental activities of daily living (IADL) difficulties among AA and Latinos compared to Non-Hispanic Whites. Understanding, preventing, and ameliorating potential health disparities is a major public health priority because poorer functional outcomes translate into disparities in quality of life and greater economic burden. Aim 2 will examine whether there are differences in key factors that are associated with functional abilities across groups. Regardless of whether there are disparities in overall level of IADL disability, there are likely to be different contributing factors (e.g., cognition, physical functioning, and medical co-morbidities). This study will address an important gap in knowledge about potential disparities and contributors to functional outcomes, which has important implications for developing effective public health policies and tailoring interventions. This supplement would allow Dr. Chan to reduce her clinical responsibilities and increase her dedicated research time, which would work towards her long-term career goal of developing an independent program of research in ADRD related disparities among ethnic minorities. This supplement would also provide a mentored research experience at the UCD Alzheimer's Disease Center that will further develop her experience in clinical research methodology and produce peer-reviewed scientific publications on ADRD, which would enhance her existing knowledge base of cognitive aging in minorities.