Pediatric Clinical Research Scholar Program - Washington

儿科临床研究学者计划 - 华盛顿

• 批准号: 7373180
• 负责人: NAOMI L LUBAN
• 金额: $ 8.3万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7373180
• 关键词: AIDS prevention; Academic Medical Centers; Acute; Adolescent; Area; Arts; Attention deficit hyperactivity disorder; Award; Awareness; Basic Science; Behavioral Medicine; Bioethics; Bioinformatics; Biometry; Brain Neoplasms; Capital; Child; Childhood; Chronic Disease; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Communicable Diseases; Data; Diagnosis; Discipline; Disease; District of Columbia; Enrollment; Environment; Epidemiology; Faculty; Fellowship; Funding; Gender; Genetic Medicine; Genetics and Medicine; Goals; Grant; HIV; Health Sciences; Health Services; Hematology; Hemochromatosis; Hepatitis C; Human Genome Project; Human Subject Research; Hypertension; Inborn Errors of Metabolism; Individual; Infant; Infant Mortality; Infectious Disease Immunology; Injury; Institute of Medicine (U.S.); Institution; Iron Overload; Knowledge; Language Disorders; Lead; Malignant Neoplasms; Managed Care; Medical center; Medicine; Mental Depression; Mentors; Methodology; Methods; Minority Groups; Morbidity - disease rate; Muscular Dystrophies; NCI Scholars Program; National Center for Research Resources; Neurosciences; Numbers; Outcome; Patient Care; Patients; Pharmaceutical Preparations; Phase; Physicians; Prevention; Public Health; Qualifying; Range; Rate; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Scientist; Services; Sickle Cell Anemia; Strategic Planning; Structure; Therapeutic; Time; Training; Training Programs; Transfusion; Translating; Underrepresented Minority; United States National Institutes of Health; Universities; University Hospitals; Washington; Woman; career; college; data management; design; disability; experience; feeding; health disparity; innovation; interest; knowledge base; leukemia; medical schools; mortality; multidisciplinary; nervous system disorder; oncology; patient oriented research; pediatric department; programs; skills; success; vaccine development; violence prevention

We propose to develop an NCRR Pediatric Clinical Research Scholars (PCRS) Program in Washington, D.C. as a consortium effort between Children's National Medical Center/George Washington University School of Medicine and Health Sciences (CNMC/GW), Georgetown University Medical Center (GUMC), and Howard University Hospital (HUH). CNMC will serve as the lead institution and is the applicant for this grant. The goal of the PCRS program is to increase the number of well-trained and innovative pediatric clinical investigators who are able to design and conduct all phases of patient-odented research and who will become leaders of multidisciplinary clinical research efforts. The Scholars will be guaranteed 75-90% protected time throughout the program (2-5 years) and will be provided training in patient-oriented research, with the goal of achieving independent NIH funding by the end of their participation in the program. With the infrastructure provided by the three NCRR-funded GCRCs at CNMC, GUMC and HUH, we believe that a successful career as an independent pediatric clinical investigator is an achievable goal for each Scholar. We will enroll a total of 12 Scholars during the first 5-years award period. In addition, we will enroll two additional "Scholars" using institutional CNMC funds as a matching grant. Both internal and external recruitment of PCRS candidates will be pursued, with an emphasis on women, underrepresented minorities, and individuals with disabilities. The individualized and structured PCRS training program will include: 1) Fundamental and comprehensive mentored training in clinical research methodology; 2) Mandatory courses relevant to clinical research that can lead to a post-graduate degree; 3) Training in the responsible conduct of research; and 4) An intensive supervised clinical research project involving one or more of the three GCRCs. Individual programs of study will be performed under the guidance of one of the 21 Lead Mentors with the help of other mentors and support faculty if required, and will be integrated across the three institutions. We have selected mentors in a wide range of disciplines in order to be able to train Scholars with diverse research interests. We also present 8 potential PCRS candidates from the consortium, 5 of whom are women, 5 are from minority groups and one has a disability. Available clinical research training areas include: Behavioral medicine and clinical neuroscience with research interests in attention deficit hyperactivity disorder (ADHD), language disorders, feeding disorders, and depression; Genetic medicine with research in sickle cell disease, hemochromatosis, inborn errors of metabolism, hypertension and muscular dystrophies; Oncology, with studies in brain tumors and leukemia; Hematology, immunology and infectious diseases with research in HIV, transfusion and Hepatitis C, iron overload and vaccine development; Experimental therapeutics with drug trials in cancer, infectious diseases, and neurological disorders; and Health services and Public Health research with research in infant mortality, violence prevention, HIV prevention in adolescents, and prediction of outcome following injury or severe illness.

我们建议在华盛顿建立NCRR儿科临床研究学者（PCRS）项目，

项目成果

Neonatal neurobehavioral abnormalities and MRI brain injury in encephalopathic newborns treated with hypothermia.

• DOI: 10.1016/j.earlhumdev.2013.05.006
• 发表时间: 2013-09
• 期刊: EARLY HUMAN DEVELOPMENT
• 影响因子: 2.5
• 作者: Coleman, Maya B.;Glass, Penny;Brown, Judy;Kadom, Nadja;Tsuchida, Tammy;Scafidi, Joseph;Chang, Taeun;Vezina, Gilbert;Massaro, An N.
• 通讯作者: Massaro, An N.

Biomarkers of brain injury in neonatal encephalopathy treated with hypothermia.

• DOI: 10.1016/j.jpeds.2012.02.047
• 发表时间: 2012-09
• 期刊: JOURNAL OF PEDIATRICS
• 影响因子: 5.1
• 作者: Massaro, An N.;Chang, Taeun;Kadom, Nadja;Tsuchida, Tammy;Scafidi, Joseph;Glass, Penny;McCarter, Robert;Baumgart, Stephen;Vezina, Gilbert;Nelson, Karin B.
• 通讯作者: Nelson, Karin B.

CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children.

CYP3A5、ABCB1 和 SLCO1B1 多态性以及洛匹那韦/利托那韦在 HIV 感染儿童中的药代动力学和病毒学结果。

• DOI: 10.1097/ftd.0b013e318225384f
• 发表时间: 2011
• 期刊: Therapeutic drug monitoring
• 影响因子: 2.5
• 作者: Rakhmanina,NatellaY;Neely,MichaelN;VanSchaik,RonHN;Gordish-Dressman,HeatherA;Williams,KeetraD;Soldin,StevenJ;vandenAnker,JohnN
• 通讯作者: vandenAnker,JohnN

Hyperphosphatemia due to fosphenytoin in a pediatric ESRD patient.

儿童终末期肾病 (ESRD) 患者因磷苯妥英导致高磷血症。

• DOI: 10.1007/s00467-005-1947-0
• 发表时间: 2005
• 期刊: Pediatric nephrology (Berlin, Germany)
• 作者: McBryde,KevinD;Wilcox,Jennifer;Kher,KanwalK
• 通讯作者: Kher,KanwalK

Nevirapine concentration in nonstimulated saliva: an alternative to plasma sampling in children with human immunodeficiency virus infection.

非刺激唾液中的奈韦拉平浓度：人类免疫缺陷病毒感染儿童血浆采样的替代方法。

• DOI: 10.1097/ftd.0b013e31803258ed
• 发表时间: 2007
• 期刊: Therapeutic drug monitoring
• 影响因子: 2.5
• 作者: Rakhmanina,NatellaY;Capparelli,EdmundV;vandenAnker,JohnN;Williams,Keetra;Sever,JohnL;Spiegel,HansML;Soldin,StevenJ
• 通讯作者: Soldin,StevenJ