CCF Musculoskeletal Core Center

CCF 肌肉骨骼核心中心

• 批准号: 7414710
• 负责人: VINCENT CHARLES HASCALL
• 金额: $ 57.87万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-25 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414710
• 关键词: CCF; Musculoskeletal; Core; Center

DESCRIPTION (provided by applicant): The Cleveland Clinic Foundation Musculoskeletal Core Center (CCFMCC). In the years since the original RFA for MCCs, musculoskeletal research activities have dramatically increased at CCF by the recruitment of Dr. Joseph Lannotti (an outstanding clinical musculoskeletal researcher) to the Chair of the Department of Orthopaedic Surgery, by the recruitment of Dr. Peter Cavanagh (an outstanding musculoskeletal biomechanics researcher) to the Chair of the Department of Biomedical Engineering, by the creation of the Orthopaedic Research Center in these two Departments, and by the recruitment of 3 new investigators into the Center. This, combined with an already strong musculoskeletal program, now provides a broadly based, interactive and well-funded Research Base for our proposed CCFMCC. Investigators in the Research Base currently are PIs on 14 NIH R01 grants, 9 of them funded by NIAMS. This clearly demonstrates the commitment of the CCF and NIH to this research. The ORC is committed to collaboration in translational research and enrichment programs. An example is the monthly Musculoskeletal Research Seminar Series that extends to Case Western Reserve University, University Hospitals Research Institute and NE Ohio Universities College of Medicine to generate synergistic research in the wider NE Ohio area. We ask, in this proposal, for funds to invite 4 national/international musculoskeletal researchers a year to enrich this already established activity. The CCFMCC would also enrich the research of the Center and CCF with 3 proposed cores: Musculoskeletal Imaging, Musculoskeletal Histology, and Musculoskeletal Robotics and Mechanical Testing, each with highly skilled Directors and Associate Directors. The imaging core was rated outstanding in our first submission and has added significantly to its resources, including microCT capabilities. The expansion of the Research Base has greatly increased the need for histology of soft and mineralized tissues and for in situ hybridization. The histology core would meet this need with high throughput, reproducible methods, particularly for tissue arrays, tissue sections and highly sensitive, non-radioactive in situ hybridization. Dr. Cavanagh has established a robotics system that, with our existing materials testing capabilities, forms the biomechanics core, adding a new and exciting dimension to investigations in the Research Base. An External Advisory Board of 5 outstanding musculoskeletal researchers has been assembled to review the Pilot and Feasibility Projects and for evaluating their progress on a yearly basis. Their stringent review of the 6 Projects prepared from the 13 originally proposed has led to the 2 that are incorporated into this application. In sum, we feel that we have all the necessary attributes to provide a highly competitive application for a MCC that would enhance our research in ways that can make a difference and contribute more significantly to musculoskeletal research.

描述(由申请人提供)： 克利夫兰临床基金会肌肉骨骼核心中心(CCFMCC)。自最初为MCC提供RFA以来，CCF通过招聘Joseph Lannotti博士(杰出的临床肌肉骨骼研究员)担任骨科主任，Peter Cavanagh博士(杰出的肌肉骨骼生物力学研究员)担任生物医学工程系主任，在这两个科室成立了矫形外科研究中心，并在该中心招聘了3名新的调查人员，极大地增加了CCF的肌肉骨骼研究活动。这一点，再加上已经很强大的肌肉骨骼项目，现在为我们提议的CCFMCC提供了一个基础广泛、互动和资金充足的研究基地。研究基地的研究人员目前是14个NIH R01赠款的私人投资机构，其中9个由NIAMS资助。这清楚地表明了CCF和NIH对这项研究的承诺。ORC致力于在翻译研究和丰富计划方面的合作。一个例子是每月一次的肌肉骨骼研究研讨会系列，该研讨会扩展到凯斯西储大学、大学医院研究所和东北俄亥俄大学医学院，以在更广泛的东北俄亥俄州地区产生协同研究。在这项提案中，我们要求提供资金，每年邀请4名国家/国际肌肉骨骼研究人员来丰富这项已经确立的活动。CCFMCC还将丰富中心和CCF的研究，建议设立3个核心：肌肉骨骼成像、肌肉骨骼组织学和肌肉骨骼机器人和机械测试，每个核心都有高技能的主任和副主任。在我们的第一次提交中，成像核心被评为杰出的，并显著增加了其资源，包括微CT能力。研究基地的扩大极大地增加了对软组织和矿化组织的组织学和原位杂交的需求。组织学核心将通过高通量、可重复性的方法来满足这一需求，特别是用于组织阵列、组织切片和高灵敏度、非放射性的原位杂交。Cavanagh博士建立了一个机器人系统，利用我们现有的材料测试能力，形成生物力学核心，为研究基地的研究增加了一个新的令人兴奋的维度。成立了一个由5名杰出的肌肉骨骼研究人员组成的外部咨询委员会，以审查试点项目和可行性项目，并每年评估其进展情况。他们对从最初提议的13个项目准备的6个项目进行了严格的审查，导致将2个项目纳入本申请。总而言之，我们认为我们拥有为MCC提供极具竞争力的应用程序的所有必要属性，这将以能够产生影响的方式加强我们的研究，并对肌肉骨骼研究做出更大贡献。

项目成果

The effect of storage medium tonicity on osteochondral autograft plug diameter.

储存介质张力对骨软骨自体移植物栓直径的影响。

• DOI: 10.1016/j.arthro.2010.07.005
• 发表时间: 2011
• 期刊: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
• 作者: Fening,StephenD;Mihnovets,Jonathon;Jones,MorganH;Midura,RonaldJ;Miniaci,Anthony
• 通讯作者: Miniaci,Anthony

Platelets govern pre-metastatic tumor communication to bone.

• DOI: 10.1038/onc.2012.447
• 发表时间: 2013-09-05
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Kerr, B. A.;McCabe, N. P.;Feng, W.;Byzova, T. V.
• 通讯作者: Byzova, T. V.

Effect of humeral head defect size on glenohumeral stability: a cadaveric study of simulated Hill-Sachs defects.

• DOI: 10.1177/0363546509350295
• 发表时间: 2010-03
• 期刊: The American journal of sports medicine
• 作者: Kaar SG;Fening SD;Jones MH;Colbrunn RW;Miniaci A
• 通讯作者: Miniaci A

Mechanical evaluation of balloon-type gastrostomy devices.

球囊型胃造口术装置的机械评估。

• DOI: 10.1615/jlongtermeffmedimplants.2013007573
• 发表时间: 2013
• 期刊: Journal of long-term effects of medical implants
• 作者: Colbrunn,RobbW;vandenBogert,AntonieJ;Mino,JeffreyS;Monteiro,Rosebel;Stallion,Anthony
• 通讯作者: Stallion,Anthony

Leptin synergizes with thyroid hormone signaling in promoting growth plate chondrocyte proliferation and terminal differentiation in vitro.

• DOI: 10.1016/j.bone.2011.02.012
• 发表时间: 2011-05
• 期刊: Bone
• 影响因子: 4.1
• 作者: Lai Wang;Yvonne Y. Shao;R. T. Ballock