EFFECTS OF SUPRAPHYSIOLOGICAL RHGH ON BONE METABOLISM IN ANOREXIA NERVOSA

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 神经性厌食症（AN）与低骨矿物质密度（BMD）有关。 研究表明AN患者存在对生长激素（一种骨合成代谢因子）的营养获得性抵抗。 我们假设AN患者的超生理rhGH将克服GH抵抗并对骨形成产生后续有益影响。22名受试者将接受单盲、随机化和安慰剂对照，同时评价rhGH在3个月内的作用。 本研究将评估骨转换标志物、身体成分和BMD。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia Nervosa (AN) is associated with a low bone mineral density (BMD). Studies suggest a nutritionally acquired resistance to GH, a bone anabolic factor, in AN. We hypothesize that supraphysiological rhGH in patients with AN will overcome the GH resistance and cause subsequent beneficial effects on bone formation. Twenty two subjects will be single blinded, randomized and placebo controlled, while evaluating the effects of rhGH over 3 months. Bone turnover markers, body composition & BMD will be evaluated in this study.