EFFECTS OF SUPRAPHYSIOLOGICAL RHGH ON BONE METABOLISM IN ANOREXIA NERVOSA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 神经性厌食症(AN)与低骨密度(BMD)有关。研究表明，在AN中，对生长激素(一种骨合成因子)存在营养获得性抵抗力。我们假设，在AN患者中，超生理学的重组人生长激素将克服生长激素抵抗，并导致随后对骨形成的有益影响。22名受试者将被单盲、随机和安慰剂对照，同时评估重组人生长激素在3个月内的效果。本研究将对骨转换指标、身体成分和骨密度进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anorexia Nervosa (AN) is associated with a low bone mineral density (BMD). Studies suggest a nutritionally acquired resistance to GH, a bone anabolic factor, in AN. We hypothesize that supraphysiological rhGH in patients with AN will overcome the GH resistance and cause subsequent beneficial effects on bone formation. Twenty two subjects will be single blinded, randomized and placebo controlled, while evaluating the effects of rhGH over 3 months. Bone turnover markers, body composition & BMD will be evaluated in this study.