GENDER-SPECIFIC EFFECTS OF PHYSIOLOGIC GH ADMINISTRATION ON CARDIOVASCULAR RISK

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will establish the gender-specific effect of physiologic GH replacement on cardiovascular risk in women with acquired GH deficiency by investigating whether this therapy: 1. has gender-specific effects on cardiovascular risk markers; 2. has gender-specific effects on lipid profiles; 3. alters heart rate variability and arterial distensibility in parallel with changes in cardiovascular risk markers; and 4. has different effects depending upon gonadal status.