EFFECTS OF PHYSIOLOGIC GROWTH HORMONE ADMINISTRATION ON CARDIOVASCULAR RISK IN

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究的目的是评估生理性生长激素（GH）替代治疗对肢端肥大症治疗后GH缺乏的男性和女性的心血管风险标志物、心脏自主神经功能、动脉扩张性、身体成分和生活质量的影响。我们假设，这一人群将代表一个新确定的一组患者的GH替代将受益。 我们将通过研究生理性GH替代治疗对肢端肥大症治愈后GHD男性和女性心血管风险的影响： 1)改善心血管风险标志物 2)改变心率变异性和动脉扩张性 3)增加瘦体重，减少脂肪量，特别是内脏脂肪组织 4)根据性腺状态的不同， 我们还将比较生长激素足够与生长激素缺乏治愈肢端肥大症的横断面研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of the study is to evaluate the effects of physiologic growth hormone (GH) replacement on cardiovascular risk markers, cardiac autonomic function, arterial distensibility, body composition, and quality of life in men and women with GH deficiency following treatment of acromegaly. We hypothesize that this population will represent a newly identified group of patients for whom GH replacement will be of benefit. We will establish the effect of physiologic GH replacement on cardiovascular risk in men and women with GHD following cure of acromegaly by investigating whether this therapy: 1) improves cardiovascular risk markers 2) alters heart rate variability and arterial distensibility 3) increases lean body mass and decreases fat mass, particularly visceral adipose tissue 4) has different effects depending upon gonadal status We will also compare GH sufficient with GH deficient cured acromegalics in a cross-sectional study.