EFFECTS OF PHYSIOLOGIC GROWTH HORMONE ADMINISTRATION ON CARDIOVASCULAR RISK IN

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of the study is to evaluate the effects of physiologic growth hormone (GH) replacement on cardiovascular risk markers, cardiac autonomic function, arterial distensibility, body composition, and quality of life in men and women with GH deficiency following treatment of acromegaly. We hypothesize that this population will represent a newly identified group of patients for whom GH replacement will be of benefit. We will establish the effect of physiologic GH replacement on cardiovascular risk in men and women with GHD following cure of acromegaly by investigating whether this therapy: 1) improves cardiovascular risk markers 2) alters heart rate variability and arterial distensibility 3) increases lean body mass and decreases fat mass, particularly visceral adipose tissue 4) has different effects depending upon gonadal status We will also compare GH sufficient with GH deficient cured acromegalics in a cross-sectional study.