EFFECTS OF PHYSIOLOGIC GROWTH HORMONE ADMINISTRATION ON CARDIOVASCULAR RISK IN

生理生长激素给药对心血管风险的影响

• 批准号: 7731317
• 负责人: ANNE KLIBANSKI
• 金额: $ 0.1万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731317
• 关键词: Acromegaly; Adipose tissue; Body Composition; Cardiac; Computer Retrieval of Information on Scientific Projects Database; Cross-Sectional Studies; Fatty acid glycerol esters; Funding; Grant; Heart Rate; Institution; Patients; Physiological; Population; Quality of life; Research; Research Personnel; Resources; Risk Marker; Somatotropin; Source; United States National Institutes of Health; Visceral; Woman; cardiovascular risk factor; growth hormone deficiency; improved; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of the study is to evaluate the effects of physiologic growth hormone (GH) replacement on cardiovascular risk markers, cardiac autonomic function, arterial distensibility, body composition, and quality of life in men and women with GH deficiency following treatment of acromegaly. We hypothesize that this population will represent a newly identified group of patients for whom GH replacement will be of benefit. We will establish the effect of physiologic GH replacement on cardiovascular risk in men and women with GHD following cure of acromegaly by investigating whether this therapy: 1) improves cardiovascular risk markers 2) alters heart rate variability and arterial distensibility 3) increases lean body mass and decreases fat mass, particularly visceral adipose tissue 4) has different effects depending upon gonadal status We will also compare GH sufficient with GH deficient cured acromegalics in a cross-sectional study.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该研究的目的是评估肢端肥大症治疗后生长激素缺乏的男性和女性生理性生长激素（GH）替代对心血管风险标志物、心脏自主功能、动脉扩张性、身体成分和生活质量的影响。我们假设这个人群将代表新发现的一组患者，GH 替代对他们来说是有益的。 我们将通过调查这种疗法是否： 1）改善心血管风险标志物 2）改变心率变异性和动脉扩张性 3）增加去脂体重并减少脂肪量，特别是内脏脂肪组织 4）根据性腺状态有不同的影响 我们还将在横断面研究中比较 GH 充足和 GH 缺乏的治愈肢端肥大症。