CLINICAL TRIAL: EFFECTS OF ANOREXIA NERVOSA ON PEAK BONE MASS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 患有神经性厌食症的青春期女孩患低骨密度的风险增加，迄今为止，尚无任何治疗方法可以成功改善该人群的骨质。 我们正在招募12-18岁患有神经性厌食症的青春期女孩，以及相同年龄范围的健康，正常体重的女孩，以确定给予低剂量雌激素是否会改善神经性厌食症患者的骨密度。 这是一项为期18个月的双盲安慰剂对照研究，合格受试者共接受4次医院访视，因为其他7次研究访视可在MGH或当地完成。 这是四个可选的过夜访问，其中包括骨密度和激素评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent girls with anorexia nervosa are at increased risk for low bone density, and no treatment has thus far been documented as successful in improving bone mass in this population. We are recruiting adolescent girls with anorexia nervosa 12-18 years old, as well as healthy, normal weight girls of the same age range, to determine whether administration of low doses of estrogen leads to an improvement in bone density in anorexia nervosa. This is an 18-month long double blind placebo-controlled research study with a total of 4 hospital visits for qualifying subjects as the 7 other study visits may be comp leted either at MGH or locally. These are four optional overnight visits, which include bone density and hormonal evaluations.