Genetics and Molecular Biology Parkinsonism

遗传学和分子生物学帕金森病

• 批准号: 8005805
• 负责人: DENNIS WILLIAM DICKSON
• 金额: $ 91.75万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8005805
• 关键词: Genetics; Molecular; Biology; Parkinsonism

The Udall Center for Excellence in Parkinson Disease Research at the Mayo Clinic is an integrated, multidisciplinary research program of neurologists, neuropsychologists, geneticists, neuropathologists and basic scientists in the study of the "Genetics and Molecular Biology of Parkinsonism." The Center draws upon the clinical strengths of the Mayo Clinic Movement Disorder Section and longitudinal studies of Parkinson disease (PD) and dementia with Lewy bodies (DLB) for the clinical material used in the research projects, as well as strong institutional commitment to PD research. The research proposed is highly synergistic despite the wide range of expertise and scientific background of the members of the Udall team. Each member of the team brings unique knowledge and skill sets to the mission, and together we are greater than the sum of the parts. The work proposed builds upon highly successful and productive cores that have been working together for over a decade. The clinical, genetic and pathologic resources are rivaled by few centers. The Mayo Udall Center is a unique complement to the Udall Center program. Success of our Udall Center has been based upon building successful collaborations and generous sharing of resources and data. This proposal has the overarching goal to better understand Lewy-related PD, which is the most common form of PD. Lewy bodies are also the hallmark of DLB and PD with dementia (PDD). How PDD and DLB relate to each other is unknown, but this non-motor complication of PD is of increasing interest to the Parkinson community. Strengths of our Udall Center are the large collection of multi-incident PD families, a proven track record of success in discovery of PD genes and a large collection of PD, PDD and DLB brains in a well annotated brain bank. The research proposal has three projects and five cores: Project 1. "Identification of genetic risk factors that predict disease onset, susceptibility and progression of PD," (PL: Matthew J. Farrer, PhD); Project 2. "Identification of candidate therapeutics for a-synuclein aggregation and cytotoxicity," (PL: Shu-Hui C. Yen, PhD); Project 3. "Molecular pathology of Lewy-related cognitive dysfunction," (PL: Dennis W. Dickson, MD); Core A. Administrative (CL: Dennis W. Dickson, MD); Core B. Clinical (CL: Zbigniew K. Wszolek, MD); Core C. Genetic (CL: Matthew J. Farrer PhD); Core D. Neuropathology (CL: Dennis W. Dickson MD) and Core E. Education and Outreach (CL: Ryan J. Uitti, MD).

梅奥诊所的尤德尔帕金森病研究卓越中心是一个由神经学家、神经心理学家、遗传学家、神经病理学家和基础科学家组成的综合多学科研究项目，研究“帕金森症的遗传学和分子生物学”。该中心利用梅奥临床运动障碍科的临床优势和帕金森病(PD)和路易体痴呆(DLB)的纵向研究作为研究项目中使用的临床材料，以及对PD研究的坚定机构承诺。尽管Udall团队成员拥有广泛的专业知识和科学背景，但拟议的研究具有高度的协同性。团队中的每一位成员都为任务带来了独特的知识和技能，我们在一起大于部件的总和。拟议的工作建立在十多年来一直在一起工作的非常成功和富有成效的核心之上。临床、遗传和病理资源几乎没有几个中心能与之匹敌。梅奥·尤德尔中心是尤德尔中心项目的独特补充。我们Udall中心的成功建立在建立成功的协作和慷慨的资源和数据共享的基础上。 这项提案的首要目标是更好地理解路易相关的帕金森病，这是帕金森病最常见的形式。路易小体也是DLB和帕金森病伴痴呆(PDD)的标志。PDD和DLB之间的关系尚不清楚，但帕金森病患者的这种非运动性并发症越来越受到帕金森病患者的关注。我们尤德尔中心的优势在于收集了大量的多事件PD家族，在发现PD基因方面取得了公认的成功记录，并在一个注释良好的脑库中收集了大量PD、PDD和DLB大脑。研究方案有三个项目和五个核心：项目1。“识别预测帕金森病发病、易感性和进展的遗传风险因素”(PL：Matthew J.Farrer，PhD)；项目2。“鉴定a-突触核蛋白聚集和细胞毒性的候选疗法”(公共部门：严淑惠博士)；项目3。核心B.临床(CL：Zbigniew K.Wszolek，MD)；核心C.Genetic(CL：Matthew J.Farrer PhD)；核心D.神经病理学(CL：Dennis W.Dickson MD)和核心E.教育和外展(CL：Ryan J.Uitti，MD)。