North Colony Field Cage Shade Structure Bid Build

北殖民地田间笼式遮阳结构投标建造

• 批准号: 10809154
• 负责人: Jeffrey A Roberts
• 金额: $ 33.98万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10809154
• 关键词: Acquired Immunodeficiency Syndrome; Administrative Supplement; Adolescent; Adult; Animal Experimentation; Animals; Area; Behavioral; Biological; Biomedical Research; Body Fluids; Breeding; California; Caring; Deterioration; Development; Dryness; Eating; Environmental Wind; Equilibrium; Excision; Exclusion; Female; Frequencies; Funding; Grant; HIV/AIDS; Head; Health; Housing; Human Resources; Infant; Institution; Longevity; Macaca; Macaca mulatta; Maintenance; Metals; Parents; Personal Satisfaction; Population; Primates; Procedures; Production; Rain; Records; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk; SIV; Sampling; Shelter facility; Simian Retroviruses; Social Dominance; Standardization; Steel; Structure; Testing; Tissues; United States; United States National Institutes of Health; Virus; age group; aged; animal care; behavioral health; foot; genetic pedigree; germ free condition; health assessment; improved; male; programs; repaired; reproductive tract; research study; seropositive; sex; simian T cell lymphotrophic virus; social; social group; square foot; the sun; viral transmission; welfare

PROJECT SUMMARY The California National Primate Research Center (CNPRC) has supported the production of Specific Pathogen Free rhesus macaques for HIV/AIDS research since 1990. The initial agents selected for exclusion included Simian Retrovirus (SRV), Simian Immmunodeficiency Virus (SIV) and Simian T Cell Lymphotrophic Virus (STLV), based on their potential to interfere with AIDS research studies. The SPF program also included Herpes B virus due to the risk posed by the presence of this virus in macaque tissue and body fluids to personnel working with rhesus macaques. Initial colony development was based on test and removal with a high frequency of testing to identity seropositive or virus- positive animals that had the potential to transmit the viruses in question. This created a colony of Specific Pathogen Free (SPF4) Indian origin rhesus macaques for AIDS research. The CNPRC has 24 half-acre field corrals that provide housing for the rhesus monkey breeding colony. Currently four are assigned to the U42 project to support the production of pedigreed SPF4 animals for AIDS research. Each of these field corrals can house approximately 150 animals but typically are formed with smaller populations of twenty males and fifty females. A typical breeding group consists of animals belonging to several age groups characterized by a strict dominance hierarchy. The CNPRC maintains detailed behavioral and social records of each social group to facilitate management decisions pertaining to breeding needs, research support and the colony’s wellbeing. Established matrilines along with several adult males provide social stability in the group formation and subsequent years. These animals are a long- term breeding resource and serve as a national resource for infants, juveniles, adults, and aged animals for use in biomedical research by investigators from throughout the United States. 18 of the existing field cages at the CNPRC already have steel overhead structures to protect the animals from the heat in the summer and the rain in the winter. Approximately 10 of these corrals were constructed in the 1970’s and have required repair and maintenance over the past 50 years. 6 of the corrals have either structural problems and/or deteriorating shade covers that were put in place to shelter the outdoor animals from both sun and rain. These canvas shade structures are damaged by wind and the sun and need replacement every few years. The requested funds will help purchase one steel overhead shelter for one of the corrals. This project will purchase a replacement 19' high, 100’ wide, and 60’ long steel-frame canopy covers (similar to patio structures) that will cover approximately one-quarter of a corresponding half-acre field corral, or 6,000 square feet. The structures will include steel framing, metal roofing, and concrete footings. Each structure has a life span of 50 years. Depending on the corral population each corral can produce between 25 to 35 infants per year. This proposal aligns with the aims of the parent U42 grant (U42OD010990) by supporting the provision of healthy, SPF Indian origin rhesus macaques for AIDS research and facilitating their care and the ability to collect biological samples safely and efficiently for research and SPF colony maintenance.

项目总结 加州国家灵长类动物研究中心(CNPRC)支持这项研究 自1990年以来，无特定病原体的恒河猴被用于艾滋病毒/艾滋病研究。首字母 被选择排除的药物包括猿猴逆转录病毒(SRV)、猿猴 免疫缺陷病毒(SIV)和猴T细胞淋巴营养病毒(STLV)，基于 它们有可能干扰艾滋病研究。SPF计划还包括 B型疱疹病毒，因为这种病毒存在于猕猴组织和 体液给与恒河猴工作的人员。最初的菌落发育是 基于高频率的检测和清除以确定血清阳性或病毒- 有可能传播相关病毒的阳性动物。这创建了一个 无特定病原体菌落(SPF4)印度源恒河猴治疗艾滋病 研究。 中国有24个半英亩的田野畜栏，为恒河猴繁殖提供住所。 殖民地。目前有四个人被分配到U42项目，以支持系谱的生产 SPF4动物用于艾滋病研究。每个田地畜栏可以容纳大约150个人。 动物，但通常是由20只雄性和50只雌性组成的较小种群。一个 典型的繁殖群体由属于几个年龄组的动物组成，其特征是 严格的统治等级制度。CNPRC保存着详细的行为和社会记录 每个社会团体为管理决策提供便利，涉及到繁殖需求、研究 支持和殖民地的福祉。已建立的母系和几只成年雄性 在群体形成和随后的几年中提供社会稳定。这些动物是一种很长的- 长期育儿资源，全国婴幼儿、少年、成人、老年人资源 供来自美国各地的研究人员用于生物医学研究的动物。第18页，共 中国石油天然气集团公司现有的野外笼子已经有钢结构，以保护 动物们远离夏天的炎热和冬天的雨水。 其中大约10个畜栏建于20世纪70年代的S时代，需要维修和 在过去的50年里，维修。6个畜栏有结构问题和/或 不断退化的遮阳物，用来保护户外动物免受两种阳光的侵袭 还有雨。这些帆布遮阳结构被风和太阳损坏，需要 每隔几年更换一次。申请的资金将用于购买一个钢材管理费用 其中一个畜栏的避难所。该项目将购买一个19‘高，100’宽，和 60英尺长的钢架天篷覆盖物(类似于露台结构)，将覆盖大约 相应的半英亩田地畜栏的四分之一，或6000平方英尺。这些结构将 包括钢框架、金属屋顶和混凝土基座。每个结构都有50年的寿命 好几年了。根据畜栏种群的不同，每个畜栏可以生产25到35只幼崽 年。 这项建议与父U42基金(U42OD010990)的目标一致，因为它支持 为艾滋病研究提供健康的SPF印度原产恒河猴，并促进其 为研究和SPF安全有效地收集生物样本的护理和能力 蜂群维护。