纯种 SPF 恒河猴的生产-猫眼课题宝

纯种 SPF 恒河猴的生产

批准号：

8830486

负责人：

Jeffrey A Roberts

金额：

$113.76万

依托单位：

UNIVERSITY OF CALIFORNIA AT DAVIS

依托单位国家：

美国

项目类别：

财政年份：

2000

资助国家：

美国

项目状态：

已结题

起止时间：

2000-09-30 至 2016-03-31

来源：

https://reporter.nih.gov/project-details/8830486

关键词：

Acquired Immunodeficiency Syndrome Address Age Alleles Animals Applications Grants Bioinformatics Biological Biomedical Research Birth Breeding California Cercopithecine Herpesvirus 1 Chinese People Cytomegalovirus Data Data Storage and Retrieval Derivation procedure Disease susceptibility Equilibrium Experimental Designs Foundations Funding Future Genetic Genetic Fingerprintings Genotype Goals Grant Haplotypes Harvest Health Homeostasis Immunity Infant Infection Lymphoid Macaca mulatta Maintenance Major Histocompatibility Complex Microsatellite Repeats Mission Mothers Nurseries Organism Pathogenesis Positioning Attribute Predisposition Primates Principal Investigator Production Records Research Research Design Research Personnel Resources Rhadinovirus Role SIV Sampling Simian Foamy Virus Solid Specific Pathogen Frees Specimen Structure Taxon Type D Retrovirus Vaccines Viral Viral Pathogenesis Virus Work animal breeding biobank cohort data management data mining data sharing digital genetic pedigree genetic profiling germ free condition microbiome pathogen prevent programs success vaccine development virology virus pathogenesis

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DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine herpesvirus 1 (B virus), simian foamy virus (SFV), rhesus cytomegalovirus (RhCMV) and rhesus rhadinovirus (RRV). This proposed expansion will be geared to the production of SPF animals for use in AIDS-related research, and to establishing a long-term self-sustaining SPF breeding colony of Indian- origin rhesus macaques with known pedigree and well-defined MHC genotypes. This colony now exceeds 350 animals and is self-sustaining through natural birth and rearing by SPF mothers. Derivation of SPF breeders through nursery-rearing of infants born to conventional breeders is no longer required.

期刊论文(4)

专著(0)

科研奖励(0)

会议论文

Effects of geographic origin on captive Macaca mulatta mitochondrial DNA variation.

DOI： --

发表时间： 2004-04

期刊：

Comparative medicine

影响因子： 0.8

作者：

[S. Kanthaswamy;D. G. Smith]

通讯作者： S. Kanthaswamy;D. G. Smith

Longitudinal patterns of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesviruses in age-structured captive breeding populations of rhesus Macaques (Macaca mulatta).

恒河猴（Macaca mulatta）年龄结构圈养繁殖群体中恒河病毒和腹膜后纤维瘤疱疹病毒的病毒血症和口腔脱落的纵向模式。

DOI： --

发表时间： 2011

期刊：

Comparative medicine

影响因子： 0.8

作者：

[White,JessicaA, Yang,Xiaowei, Todd,PatriciaA, Lerche,NicholasW]

通讯作者： Lerche,NicholasW

Genetic characterization of specific pathogen-free rhesus macaque (Macaca mulatta) populations at the California National Primate Research Center (CNPRC).

DOI： 10.1002/ajp.20811

发表时间： 2010-06

期刊：

AMERICAN JOURNAL OF PRIMATOLOGY

影响因子： 2.4

作者：

[Kanthaswamy, Sree, Kou, Alex, Satkoski, Jessica, Penedo, Maria Cecilia T., Ward, Thea, Ng, Jillian, Gill, Leanne, Lerche, Nicholas W., Erickson, Bethany J-A, Smith, David Glenn]

通讯作者： Smith, David Glenn