Production of Pedigreed SPF Rhesus Macaques

纯种 SPF 恒河猴的生产

• 批准号: 8830486
• 负责人: Jeffrey A Roberts
• 金额: $ 113.76万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8830486
• 关键词: Acquired Immunodeficiency Syndrome; Address; Age; Alleles; Animals; Applications Grants; Bioinformatics; Biological; Biomedical Research; Birth; Breeding; California; Cercopithecine Herpesvirus 1; Chinese People; Cytomegalovirus; Data; Data Storage and Retrieval; Derivation procedure; Disease susceptibility; Equilibrium; Experimental Designs; Foundations; Funding; Future; Genetic; Genetic Fingerprintings; Genotype; Goals; Grant; Haplotypes; Harvest; Health; Homeostasis; Immunity; Infant; Infection; Lymphoid; Macaca mulatta; Maintenance; Major Histocompatibility Complex; Microsatellite Repeats; Mission; Mothers; Nurseries; Organism; Pathogenesis; Positioning Attribute; Predisposition; Primates; Principal Investigator; Production; Records; Research; Research Design; Research Personnel; Resources; Rhadinovirus; Role; SIV; Sampling; Simian Foamy Virus; Solid; Specific Pathogen Frees; Specimen; Structure; Taxon; Type D Retrovirus; Vaccines; Viral; Viral Pathogenesis; Virus; Work; animal breeding; biobank; cohort; data management; data mining; data sharing; digital; genetic pedigree; genetic profiling; germ free condition; microbiome; pathogen; prevent; programs; success; vaccine development; virology; virus pathogenesis

DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine herpesvirus 1 (B virus), simian foamy virus (SFV), rhesus cytomegalovirus (RhCMV) and rhesus rhadinovirus (RRV). This proposed expansion will be geared to the production of SPF animals for use in AIDS-related research, and to establishing a long-term self-sustaining SPF breeding colony of Indian- origin rhesus macaques with known pedigree and well-defined MHC genotypes. This colony now exceeds 350 animals and is self-sustaining through natural birth and rearing by SPF mothers. Derivation of SPF breeders through nursery-rearing of infants born to conventional breeders is no longer required.

描述（申请人提供）：该提案的目标是继续扩大具有遗传特征的印度血统恒河猴的生产，这些恒河猴对7种持续存在的病毒无特异性病原体（SPF），包括猿猴免疫缺陷病毒（SIV）、猿猴D型逆转录病毒（SRV）、猿猴T淋巴细胞病毒（STLV）、猕猴疱疹病毒1型（B病毒）、猿猴泡沫病毒（SFV）、恒河猴巨细胞病毒（RhCMV）和恒河猴鼻状病毒（RRV）。这一拟议的扩展将适合于生产SPF动物用于艾滋病相关研究，并建立一个长期自我维持的SPF繁殖群的印度起源的恒河猴与已知的血统和明确的MHC基因型。这个群体现在超过350只动物，通过自然分娩和SPF母亲的养育而自我维持。不再需要通过托儿所养育传统育种者所生婴儿来获得SPF育种者。

项目成果

Effects of geographic origin on captive Macaca mulatta mitochondrial DNA variation.

• 发表时间: 2004-04
• 期刊: Comparative medicine
• 影响因子: 0.8
• 作者: S. Kanthaswamy;D. G. Smith

Longitudinal patterns of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesviruses in age-structured captive breeding populations of rhesus Macaques (Macaca mulatta).

恒河猴（Macaca mulatta）年龄结构圈养繁殖群体中恒河病毒和腹膜后纤维瘤疱疹病毒的病毒血症和口腔脱落的纵向模式。

• 发表时间: 2011
• 期刊: Comparative medicine
• 影响因子: 0.8
• 作者: White,JessicaA;Yang,Xiaowei;Todd,PatriciaA;Lerche,NicholasW
• 通讯作者: Lerche,NicholasW

Genetic characterization of specific pathogen-free rhesus macaque (Macaca mulatta) populations at the California National Primate Research Center (CNPRC).

• DOI: 10.1002/ajp.20811
• 发表时间: 2010-06
• 期刊: AMERICAN JOURNAL OF PRIMATOLOGY
• 影响因子: 2.4
• 作者: Kanthaswamy, Sree;Kou, Alex;Satkoski, Jessica;Penedo, Maria Cecilia T.;Ward, Thea;Ng, Jillian;Gill, Leanne;Lerche, Nicholas W.;Erickson, Bethany J-A;Smith, David Glenn
• 通讯作者: Smith, David Glenn