Center for Clinical and Translational Science and Training

联系人 PD/PI：Heubi, James E 总体 摘要 临床和转化科学与培训中心（CCTST）在大学成立 2005 年获得辛辛那提 (UC) 博士学位，并于 2009 年荣获机构临床和转化科学奖 (CTSA)。 从那时起，基础科学研究、基因组学、技术和药物开发取得了令人瞩目的成就 进步，保证将研究转化为实践的新解决方案。与这些发现同时， CCTST 为我们的项目功能创建了创新的解决方案，包括生物医学信息学、 生物统计学和研究设计、监管和伦理、社区参与和团队科学、招聘 以及对临床试验、患者护理互动、试点资助和转化劳动力发展的支持。 随着竞争性续签申请以及目前CCTST 3.0的修订和创建，我们将继续 利用学习卫生系统的指导原则，与以下机构建立更牢固的双向关系 我们的社区并迅速将发现付诸应用。事实上，我们打算捕捉这一巨大的 更好地将卫生系统的临床/运营任务与研究任务结合起来的机会 大学及其附属机构。 CCTST 的总体目标是最大限度地发挥临床和 通过以下方式进行转化研究，以改善当地和全国范围内的个人和人口健康：1) 参与 利益相关者合作将研究转化为改善的医疗保健实践和社区健康 贯穿整个生命周期； 2) 培养一支多元化、多学科的员工队伍，以开展创新、团队合作、 社区参与的转化研究，并传播和实施改善健康的研究结果 结果并减少差距； 3）优化生物医学数据在转化过程中的使用 使用创新数据科学方法来推进发现、传播和研究的连续体 实施。对于每个计划和可选功能，这些目标都是计划的基础 创新活动并促进跨核心集成。我们特别将学习健康系统作为 由于辛辛那提儿童医院医疗中心拥有专业知识，因此该应用程序的可选模块 该中心可在 CCTST 及其医疗保健附属机构中利用。为了实现这些目标，CCTS 3.0 将促进将发现转化为改善当地和全国的健康结果。 第307页 项目概要/摘要 联系人 PD/PI：Heubi, James E 叙事 CTSA 联盟已经成熟，有 57 个站点正在共同努力，与 提高国民健康水平的目标。辛辛那提大学临床和转化中心 科学和培训已成为临床和转化研究人员获得支持的入口 完成从实验室到人群的转化科学领域的研究 健康。通过此修订后的续展申请，我们将开发更多创新方法来生产高品质产品 高质量的研究，分享这些发现，与其他 CTSA 中心合作，并产生可衡量的影响 利用学习健康系统的原则来关注我们社区的健康。 第308页

Contact PD/PI: Heubi, James E OVERALL ABSTRACT The Center for Clinical and Translational Science and Training (CCTST) was established at the University of Cincinnati (UC) in 2005 and awarded an institutional Clinical and Translational Science Award (CTSA) in 2009. Since that time, basic science research, genomics, technology, and drug development have made remarkable progress, warranting new solutions for translating research to practice. Concurrent with these discoveries, the CCTST has created innovative solutions for our program functions, including biomedical informatics, biostatistics and study design, regulatory and ethics, community engagement and team science, recruitment and support for clinical trials, patient care interactions, pilot grants, and translational workforce development. With the competitive renewal application and the current revision and creation of CCTST 3.0, we will continue to utilize the guiding principles of learning health systems to develop stronger bidirectional relationships with our community and expeditiously bring discoveries to application. Indeed, we intend to capture this tremendous opportunity to better align the clinical/operational mission of the health system with the research mission of the University and its affiliates. The overarching goal of the CCTST is to maximize the impact of clinical and translational research to improve individual and population health locally and nationally, through 1) engaging stakeholders to collaboratively translate research into improved health care practice and community wellness across the lifespan; 2) developing a diverse, multidisciplinary workforce to conduct innovative, team-based, community-engaged translational research and to disseminate and implement findings that will improve health outcomes and reduce disparities; and 3) optimizing the use of biomedical data across the translational research continuum using innovative data science methods to advance discovery, dissemination, and implementation. For each of the programs and optional functions, these aims serve as the basis for planned innovative activities and to facilitate cross-core integration. We specifically target learning health systems as an optional module for this application because of the expertise available at Cincinnati Children's Hospital Medical Center that can be leveraged across the CCTST and its health care affiliates. In fulfilling these aims, CCTST 3.0 will catalyze the translation of discoveries into improved health outcomes locally and nationally. Page 307 Project Summary/Abstract Contact PD/PI: Heubi, James E NARRATIVE The CTSA consortium has matured to the point that 57 sites are working together to advance science with the goal to improve the health of the nation. The University of Cincinnati Center for Clinical and Translational Science and Training has become a portal of entry for clinical and translational investigators to obtain support for the completion of their studies across the spectrum of translational science, from the bench to population health. With this revised renewal application, we will develop additional innovative methods to produce high quality research, share these discoveries, collaborate with other CTSA hubs, and have a measurable impact on the health of our community using the principles of a learning health system. Page 308