Center for Clinical and Translational Science and Training

联系PD/PI：Heubi，James E 总体来说 摘要 临床和翻译科学与培训中心(CCTST)在加州大学成立 2005年在辛辛那提(加州大学)获奖，并于2009年荣获机构临床和翻译科学奖(CTSA)。 从那时起，基础科学研究、基因组学、技术和药物开发取得了令人瞩目的成就 进步，为将研究转化为实践提供了新的解决方案。在这些发现的同时， CCTST为我们的项目职能创造了创新的解决方案，包括生物医学信息学， 生物统计学和研究设计、监管和伦理、社区参与和团队科学、招聘 并支持临床试验、患者护理互动、试点拨款和翻译劳动力发展。 随着竞争续签申请和CCTST 3.0的当前修订和创建，我们将继续 利用学习卫生系统的指导原则，与 我们的社区，并迅速将发现应用。事实上，我们打算捕捉到这一巨大的 更好地使卫生系统的临床/业务使命与卫生系统的研究使命保持一致的机会 大学及其附属机构。CCTST的首要目标是最大限度地发挥临床和 通过1)参与旨在改善地方和国家个人和人口健康的转化性研究 利益相关者协作将研究转化为改进的医疗实践和社区健康 在整个生命周期内；2)发展多样化、多学科的员工队伍，以进行创新、基于团队的 社区参与的翻译研究，并传播和实施将改善健康的研究结果 结果和减少差异；以及3)优化生物医学数据的使用 使用创新的数据科学方法推动发现、传播和 实施。对于每个方案和可选功能，这些目标是计划的基础 开展创新活动，促进跨核心一体化。我们特别将学习卫生系统作为一种 此应用程序的可选模块，因为辛辛那提儿童医院医疗中心提供的专业知识 可在CCTST及其医疗保健附属机构中使用的中心。在实现这些目标的过程中，科技委 3.0将促进将发现转化为改善地方和国家的健康结果。 第307页 项目摘要/摘要 联系PD/PI：Heubi，James E 叙事 CTSA联盟已经成熟到57个地点正在共同努力，与 目标是提高国民健康水平。辛辛那提大学临床与翻译中心 科学和培训已成为临床和翻译研究人员获得支持的入口 为了完成他们在翻译科学领域的研究，从长凳到人群 健康。有了这次修订的续期申请，我们将开发更多的创新方法来产生高 高质量的研究，分享这些发现，与其他CTSA中心协作，并产生可衡量的影响 使用学习型健康系统的原则来维护我们社区的健康。 第308页

Contact PD/PI: Heubi, James E OVERALL ABSTRACT The Center for Clinical and Translational Science and Training (CCTST) was established at the University of Cincinnati (UC) in 2005 and awarded an institutional Clinical and Translational Science Award (CTSA) in 2009. Since that time, basic science research, genomics, technology, and drug development have made remarkable progress, warranting new solutions for translating research to practice. Concurrent with these discoveries, the CCTST has created innovative solutions for our program functions, including biomedical informatics, biostatistics and study design, regulatory and ethics, community engagement and team science, recruitment and support for clinical trials, patient care interactions, pilot grants, and translational workforce development. With the competitive renewal application and the current revision and creation of CCTST 3.0, we will continue to utilize the guiding principles of learning health systems to develop stronger bidirectional relationships with our community and expeditiously bring discoveries to application. Indeed, we intend to capture this tremendous opportunity to better align the clinical/operational mission of the health system with the research mission of the University and its affiliates. The overarching goal of the CCTST is to maximize the impact of clinical and translational research to improve individual and population health locally and nationally, through 1) engaging stakeholders to collaboratively translate research into improved health care practice and community wellness across the lifespan; 2) developing a diverse, multidisciplinary workforce to conduct innovative, team-based, community-engaged translational research and to disseminate and implement findings that will improve health outcomes and reduce disparities; and 3) optimizing the use of biomedical data across the translational research continuum using innovative data science methods to advance discovery, dissemination, and implementation. For each of the programs and optional functions, these aims serve as the basis for planned innovative activities and to facilitate cross-core integration. We specifically target learning health systems as an optional module for this application because of the expertise available at Cincinnati Children's Hospital Medical Center that can be leveraged across the CCTST and its health care affiliates. In fulfilling these aims, CCTST 3.0 will catalyze the translation of discoveries into improved health outcomes locally and nationally. Page 307 Project Summary/Abstract Contact PD/PI: Heubi, James E NARRATIVE The CTSA consortium has matured to the point that 57 sites are working together to advance science with the goal to improve the health of the nation. The University of Cincinnati Center for Clinical and Translational Science and Training has become a portal of entry for clinical and translational investigators to obtain support for the completion of their studies across the spectrum of translational science, from the bench to population health. With this revised renewal application, we will develop additional innovative methods to produce high quality research, share these discoveries, collaborate with other CTSA hubs, and have a measurable impact on the health of our community using the principles of a learning health system. Page 308