Center for Clinical and Translational Science and Training

联系PD/PI：Heubi，James E 整体 摘要 临床和转化科学与培训中心（CCTST）成立于大学， 辛辛那提（UC），并于2009年获得临床和转化科学奖（CTSA）。 从那时起，基础科学研究，基因组学，技术和药物开发取得了显着的成就 取得进展，为将研究转化为实践提供新的解决方案。与这些发现同时， CCTST为我们的项目功能创造了创新的解决方案，包括生物医学信息学， 生物统计学和研究设计、法规和伦理、社区参与和团队科学、招募 并支持临床试验、患者护理互动、试点赠款和翻译劳动力发展。 随着竞争性的续约申请和目前的修订和创建的CCTST 3.0，我们将继续 利用学习卫生系统的指导原则与发展更强有力的双向关系 我们的社区，并迅速把发现应用。事实上，我们打算抓住这个巨大的 有机会更好地调整卫生系统的临床/业务使命与研究使命的 大学及其附属机构。CCTST的总体目标是最大限度地提高临床和 转化研究，以改善个人和人口健康的地方和国家，通过1）参与 利益相关者合作将研究转化为改善的医疗保健实践和社区健康 2）发展一支多元化，多学科的员工队伍，以进行创新，以团队为基础， 社区参与的转化研究，并传播和实施将改善健康的发现 结果和减少差异; 3）优化生物医学数据在翻译过程中的使用 研究连续体使用创新的数据科学方法来推进发现，传播， 实施.对于每个程序和可选功能，这些目标是计划的基础。 创新活动并促进跨核心整合。我们专门针对学习健康系统， 由于辛辛那提儿童医院医疗部提供的专业知识， 该中心可以在CCTST及其医疗保健附属机构中发挥作用。为了实现这些目标，CCTST 3.0将促进将发现转化为改善当地和国家的健康结果。 第三百零七页 项目总结/摘要 联系PD/PI：Heubi，James E 叙事 CTSA联盟已经成熟到57个站点正在共同努力， 目标是提高国民健康水平。辛辛那提大学临床和转化中心 科学与培训已经成为临床和翻译研究者获得支持的入口 完成他们在转化科学领域的研究，从实验室到人口 健康通过这次修订的更新申请，我们将开发更多的创新方法， 质量研究，分享这些发现，与其他CTSA中心合作，并产生可衡量的影响 利用学习型健康系统的原则来改善我们社区的健康状况。 页面308

Contact PD/PI: Heubi, James E OVERALL ABSTRACT The Center for Clinical and Translational Science and Training (CCTST) was established at the University of Cincinnati (UC) in 2005 and awarded an institutional Clinical and Translational Science Award (CTSA) in 2009. Since that time, basic science research, genomics, technology, and drug development have made remarkable progress, warranting new solutions for translating research to practice. Concurrent with these discoveries, the CCTST has created innovative solutions for our program functions, including biomedical informatics, biostatistics and study design, regulatory and ethics, community engagement and team science, recruitment and support for clinical trials, patient care interactions, pilot grants, and translational workforce development. With the competitive renewal application and the current revision and creation of CCTST 3.0, we will continue to utilize the guiding principles of learning health systems to develop stronger bidirectional relationships with our community and expeditiously bring discoveries to application. Indeed, we intend to capture this tremendous opportunity to better align the clinical/operational mission of the health system with the research mission of the University and its affiliates. The overarching goal of the CCTST is to maximize the impact of clinical and translational research to improve individual and population health locally and nationally, through 1) engaging stakeholders to collaboratively translate research into improved health care practice and community wellness across the lifespan; 2) developing a diverse, multidisciplinary workforce to conduct innovative, team-based, community-engaged translational research and to disseminate and implement findings that will improve health outcomes and reduce disparities; and 3) optimizing the use of biomedical data across the translational research continuum using innovative data science methods to advance discovery, dissemination, and implementation. For each of the programs and optional functions, these aims serve as the basis for planned innovative activities and to facilitate cross-core integration. We specifically target learning health systems as an optional module for this application because of the expertise available at Cincinnati Children's Hospital Medical Center that can be leveraged across the CCTST and its health care affiliates. In fulfilling these aims, CCTST 3.0 will catalyze the translation of discoveries into improved health outcomes locally and nationally. Page 307 Project Summary/Abstract Contact PD/PI: Heubi, James E NARRATIVE The CTSA consortium has matured to the point that 57 sites are working together to advance science with the goal to improve the health of the nation. The University of Cincinnati Center for Clinical and Translational Science and Training has become a portal of entry for clinical and translational investigators to obtain support for the completion of their studies across the spectrum of translational science, from the bench to population health. With this revised renewal application, we will develop additional innovative methods to produce high quality research, share these discoveries, collaborate with other CTSA hubs, and have a measurable impact on the health of our community using the principles of a learning health system. Page 308