Core-006

临床和翻译科学与培训中心(CCTST)必须有足够的支持 多样化的网络活动，以促进临床和转化性研究的成功。我们的最后一场比赛 续订首次包含网络资源部分，以及可选功能。关于…… 可选功能，我们提交了：1)急性护理研究；2)寿命数据集成。对于网络 资源和多站点研究支持，我们专注于本地研究人员通过我们的 两个临床试验办公室(CTO)，因为试验创新网络(TIN)尚未形成。在这 竞争续订，CCTST 3.0，我们继续以相同的方式支持当地多站点调查人员，包括 一些重大变化正在进行中，以改善整个学术健康中心(AHC)的CTO服务。在……里面 此外，我们有一个功能齐全的TIN中心联络团队，并与TIN进行了越来越多的合作。 我们现在有两名当地调查人员接受TIN服务，并正在继续参与TIN 审判。我们打算进一步加强AHC范围内的合作，以支持多地点的人类受试者研究。 我们已将急性护理研究核心作为科技委的一项永久功能投入运作。这是建立在 迄今为止，急性护理研究可选功能的成功利用了我们在以下方面的许多独特优势 急性护理研究，并强调了急性护理研究在我们的AHC中的重要性。我们将采用 学习卫生系统指导原则在网络资源持续改进中的应用 以及与其他CCTST核心的密切合作。我们将1)与利益相关者接洽 进行有意义的多点临床研究，包括进一步参与TIN研究；2)继续开发 拥有多站点研究，特别是急性护理研究专业知识的多学科员工队伍；以及3)优化 使用生物医学数据支持地方和国家临床研究的各个方面。

The Center for Clinical and Translational Science and Training (CCTST) must have adequate support of diverse network-wide activities to facilitate success in clinical and translational research. Our last competing renewal contained a Network Resources section for the first time, as well as Optional Functions. With regard to Optional Functions, we submitted: 1) Acute Care Research; and 2) Lifespan Data Integration. For Network Resources and Multi-Site Study Support, we focused on local investigator support for multi-site trials via our two Clinical Trial Offices (CTOs), since the Trial Innovation Network (TIN) had not yet been formed. In this competing renewal, CCTST 3.0, we continue to support local multi-site investigators in the same fashion, with some significant changes underway to improve CTO services across the Academic Health Center (AHC). In addition, we have a fully functional TIN Hub Liaison Team and have had increasing collaboration with the TIN. We now have two local investigators receiving TIN services and are continuing toward our participation in TIN trials. We intend to further increase AHC-wide collaboration in support of multi-site human subjects research. We have operationalized the Acute Care Research Core as a permanent feature of the CCTST. This builds on the success of the Acute Care Research optional function to date, leverages our many unique strengths in acute care research, and highlights the importance of acute care research within our AHC. We will adopt the guiding principles of Learning Health Systems applied to continuous improvement of our Network Resources described herein, along with close collaboration with the other CCTST cores. We will 1) engage stakeholders in meaningful multi-site clinical research, including further involvement in TIN studies; 2) continue to develop a multidisciplinary workforce with expertise in multi-site research, especially acute care research; and 3) optimize the use of biomedical data in support of all aspects of clinical research locally and nationally.