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中文摘要
翻译
临床与转化科学中心中心研究能力核心的目标 培训(CCTST)是为了支持未来的临床和转化性研究企业。中概述的 FOA,该中心包括两个核心:参与者和临床互动(PCI)和整合特殊 人口(互联网服务提供商)。PCI Core将专注于改善基础设施和流程,以进行临床 和翻译研究,总体目标是提高参与者和调查人员的体验。 这将通过以下具体目标来实现:1)让利益相关者参与进行临床 和翻译研究;2)促进未来多样化、多学科的劳动力队伍的发展;以及 3)优化流程,在安全的环境中进行高质量的研究。的示例 实现这些目标的方法包括:通过开展一年两次的调查使利益攸关方参与进来; 将临床和转化研究能力扩展到服务不足的人群和健康人群 通过移动单位的差异;开发临床研究的技能培训,以提供临床知识 研究执行情况和可供研究人员和研究小组使用的资源;精简 方案评估、审查、批准和监控;并利用最先进的临床和翻译 研究中心(CTRC)基础设施和高素质的研究人员进行第一人 基因治疗或使用有机化合物治疗疾病等治疗。CCTST有很强的 将特殊人群有效整合到临床和转化性研究中的历史。我们的整合 特殊人口倡议(ISPI)将建立在完善的方案的基础上,通过增加 研究设计中的特殊人群,并为研究团队配备克服 特殊人群参与研究的障碍。为了实现这一目标,我们将1)支持创新 使代表性不足的人群参与研究的战略;2)扩大基础设施支持 将特殊人群纳入研究;以及3)优化特殊人群的招募,使用 生物医学数据。这些努力将导致卫生保健提供者、社区 合作伙伴和研究人员有权发起新的研究,以影响最脆弱和最艰难的人 以接触到健康差距负担最大的特殊人群。
英文摘要
The goal of the Hub Research Capacity Core of the Center for Clinical and Translational Science and Training (CCTST) is to support the clinical and translational research enterprise of the future. As outlined in the FOA, the Hub includes two cores: Participant and Clinical Interactions (PCI) and Integrating Special Populations (ISP). The PCI Core will focus on improvement of infrastructure and processes to conduct clinical and translational research, with an overall goal to enhance the experience of participants and investigators. This will be accomplished through the following Specific Aims: 1) engage stakeholders in conducting clinical and translational research; 2) promote development of a diverse, multidisciplinary workforce of the future; and 3) optimize the processes to conduct high-quality research studies in a safe environment. Examples of the approaches to accomplish these aims include: engaging stakeholders through conducting biannual surveys; extending clinical and translational research capabilities to underserved populations and those with health disparities through a mobile unit; developing skills training in clinical research to provide knowledge on clinical research implementation and the resources available to study investigators and study teams; streamlining protocol assessment, review, approval, and monitoring; and utilizing state-of-art Clinical and Translational Research Center (CTRC) infrastructure and highly qualified research personnel to conduct first-in-man treatments such as gene therapy or use of organoids for treatment of diseases. The CCTST has a strong history of effectively integrating special populations into clinical and translational research. Our Integrating Special Populations Initiative (ISPI) will build on well-developed programs by increasing the participation of special populations in research design and equipping research teams with the tools needed to overcome barriers to research participation for special populations. To achieve this goal, we will 1) support innovative strategies for engaging underrepresented populations in research studies; 2) expand infrastructure support for integrating special populations into research; and 3) optimize recruitment of special populations using biomedical data. These efforts will result in the development of a network of health care providers, community partners, and researchers empowered to launch new research that will impact the most vulnerable and hardest to reach special populations experiencing the greatest burden of health disparities.
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Core-008
  • 批准号:
    10409673
  • 项目类别:
  • 资助金额:
    $10.14万
  • 财政年份:
    2015
  • 负责人:
    JAMES E. HEUBI
  • 依托单位:
Core-005
  • 批准号:
    10409669
  • 项目类别:
  • 资助金额:
    $60.76万
  • 财政年份:
    2015
  • 负责人:
    JAMES E. HEUBI
  • 依托单位:
Admin-Core-001
  • 批准号:
    10613551
  • 项目类别:
  • 资助金额:
    $45.14万
  • 财政年份:
    2015
  • 负责人:
    JAMES E. HEUBI
  • 依托单位:
Core-002
  • 批准号:
    10613555
  • 项目类别:
  • 资助金额:
    $105.65万
  • 财政年份:
    2015
  • 负责人:
    JAMES E. HEUBI
  • 依托单位:
国内基金
海外基金
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data