Center for Central Nervous System Function

中枢神经系统功能中心

• 批准号: 10246477
• 负责人: JEROME N SANES
• 金额: $ 243.34万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246477
• 关键词: Affect; Affective; American; Anxiety; Area; Attention; Award; Behavior; Behavioral; Biological Models; Brain; Brain imaging; Centers of Research Excellence; Client; Cognition; Cognitive; Communities; Computational Biology; Decision Making; Disease; Distant; Ensure; Event; Experimental Animal Model; Experimental Designs; Faculty; Faculty Recruitment; Failure; Family; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Genetic; Goals; Grant; Health; Human; Human Resources; Impairment; Individual; Institutes; Internet; Knowledge; Laboratories; Learning; Mediating; Mental disorders; Mentors; Methods; Molecular; Monitor; Neocortex; Nervous System Physiology; Neuraxis; Pattern; Perception; Phase; Pilot Projects; Positioning Attribute; Preparation; Privatization; Procedures; Process; Production; Psyche structure; Publications; Publishing; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Rhode Island; Role; Rotation; Schedule; Science; Sensory; Signal Transduction; Site; Source; Structure; Technology; Training and Infrastructure; United States; United States National Institutes of Health; Universities; Work; anxiety-related disorders; base; career development; cognitive neuroscience; community based participatory research; computerized tools; cost; design; experimental analysis; faculty mentor; falls; human disease; magnetic resonance imaging/electroencephalography; member; mid-career faculty; mind control; multimodality; neocortical; nervous system disorder; neuroimaging; neuromechanism; neurotransmission; nonhuman primate; novel; operation; programs; recruit; relating to nervous system; research and development; senior faculty; sensory stimulus; skills; social; success; tool

Purposeful human behavior requires attention, decisions and construction and production of abstract sequences, all basic functions mediated by brain networks primarily located in the neocortex, but modulated and shaped by sub-cortical processing. In a general and even a specific sense, attention, decision making and production of abstract sequences are key components of human mental activities. Deficits in these functions are common in both neurological and psychiatric disorders and can result in a wide range of higher-order behavioral deficits, including anxiety. We propose to continue, for at least another five years, the COBRE Center for Central Nervous System Function at Brown University that will investigate the mechanisms of higher-brain function focusing on decision making, abstract sequence construction and attention, while developing statistically valid tools to reveal brain connectivity pattern. This COBRE consists of four research projects led by junior faculty and one by an established investigator. Shenhav will investigate brain mechanisms of cognitive interference during value based decision using multi-modal brain recordings. Desrochers will investigate the neural basis of sequence monitoring in humans and non-human primates using neuroimaging and circuit disruption. FeldmanHall will examine the neural and affective mechanisms of socially risky learning using neuroimaging and behavior. Eloyan will develop quantitative methods for brain connectivity network estimation and inference using functional MRI signals. Jones will investigate the causal role of neocortical beta events in human sensory perception. A Design and Analysis Core and a Behavior and Neuroimaging Core will facilitate the research goals of these projects and benefit the broader Brown community by developing new tools and optimizing existing ones to image brain structure and function with MRI and EEG, while insuring proper experimental design and analysis procedures across the projects. Project Leaders will have senior faculty mentors who will provide support and guidance on research, publication, grant preparation, and career development. An Administrative Core will oversee the operations of this COBRE Center. The COBRE Center for Central Nervous System Function will fall under the auspices of the Brown Institute for Brain Science. The COBRE Center will leverage the administrative resources available through the Brown Institute for Brain Science to ensure efficient operation and coordinate with other brain science research activities at Brown.

有目的的人类行为需要注意、决策和抽象的建构与生产 序列，所有的基本功能都是由大脑网络介导的，主要位于新皮层，但被调制， 并通过皮层下加工形成。在一般甚至具体的意义上，注意力、决策和 摘要抽象序列的产生是人类思维活动的重要组成部分。这些职能的缺陷 在神经和精神疾病中很常见，并可导致广泛的高阶 行为缺陷包括焦虑我们建议继续进行COBRE，至少再持续五年， 布朗大学中枢神经系统功能中心将研究 高级大脑功能集中在决策，抽象序列构建和注意力，而 开发统计有效的工具来揭示大脑连接模式。COBRE包括四项研究 项目由初级教师和一个由一个既定的调查。Shenhav将调查大脑 使用多模态大脑记录进行基于价值的决策过程中的认知干扰机制。 Desrochers将研究人类和非人类灵长类动物序列监测的神经基础， 神经成像和电路中断FeldmanHall将研究社交活动的神经和情感机制。 利用神经影像学和行为学进行冒险学习。Eloyan将开发大脑连接的定量方法 使用功能性MRI信号的网络估计和推断。琼斯将调查的因果作用， 人类感官知觉中的新皮层β事件。一个设计和分析的核心，一个行为和 Neuroimaging Core将促进这些项目的研究目标，并使更广泛的布朗受益。 通过开发新工具和优化现有工具来成像大脑结构和功能， MRI和EEG，同时确保整个项目的适当实验设计和分析程序。项目 领导者将有高级教师导师谁将提供支持和指导的研究，出版，赠款 准备和职业发展。一个行政核心将监督这个COBRE的运作 中心COBRE中枢神经系统功能中心将由布朗大学赞助。 脑科学研究所。COBRE中心将通过 布朗脑科学研究所确保有效运作，并与其他脑科学研究协调 布朗的活动