CTSA Predoctoral T32 at Tufts University

项目摘要 我们建议大幅扩大塔夫茨生物医学科学研究生院的机会， 临床和转化科学（CTS）的博士前培训。根据我们最近的经验， 在我们建立的博士后项目中，我们发现早期接触CTS 培训可以深刻影响学者的职业轨迹，丰富所有人的学习环境 学员水平。塔夫茨CTS研究生课程，塔夫茨临床和翻译的培训核心 科学研究所（CTSI），在培养临床研究和CTS领导者方面有着悠久而杰出的历史。 成立于1999年，是美国第一个基于生物医学研究生院的临床研究项目。 科学和学术医疗中心，我们不断发展，以满足CTS不断变化的需求 训练现在，我们力求在成功经验的基础上，扩大我们的影响力， 通过培养博士前培训生来应对未来的医疗挑战。随着世界从 在COVID-19大流行期间，让学员在职业生涯早期参与CTS研究的情况从未如此 变得更坚强虽然我们不能完全预测博士前学员将面临的具体医疗挑战， 面对未来几十年的挑战，我们可以看到无疑将占主导地位的新兴主题。例如它 似乎可以肯定的是，未来的医疗保健解决方案将越来越依赖于真实的世界证据， 机器学习和常规收集的大数据的融合。此外，从COVID-19中可以清楚地看出， 19大流行，人类，动物和环境之间的相互作用将是一个关键，也许 我们的健康和生存的决定因素。最后，虽然富人似乎正在达到我们的自然 寿命，持久的社会经济差距估计约占三分之一的过早 即使在高度发达国家也有死亡;健康方面的重大进展无疑取决于解决社会问题， 健康的决定因素和其他造成差异的原因。这些问题，与塔夫茨的优势， 塑造了我们的三个专门的T32计划轨道：预测分析和比较有效性 研究（PACER），一个健康，健康政策和健康差距（HPHD）。因此，响应 为了响应NCATS培养更多博士前学者的号召，我们有两个主要目标：目标1：培养和准备 有前途的专业学生作为医学研究学者，致力于他们的职业生涯，临床和 转化科学我们将为专业学生提供途径（例如，MD、DVM、DMD、DPT） 通过证书，MS或CTS博士水平的培训来加强他们的临床教育。目标2：准备博士学位 候选人作为转化研究学者，开始未来的职业生涯，作为临床和 翻译科学家我们将招募和培训具有生物医学背景的候选人进入我们的CTS 博士课程;并为相关领域的博士生提供途径（例如，基础科学、计算机 科学，营养），以加强他们的研究培训与证书或MS级培训CTS。

Project Summary We propose to substantially expand opportunities at the Tufts Graduate School of Biomedical Sciences for predoctoral training in clinical and translational science (CTS). Based on our recent experience integrating predoctoral students in our established postdoctoral program, we have found that early exposure to CTS training can profoundly influence the career trajectories of scholars and enrich the learning environment for all levels of trainees. The Tufts CTS Graduate Program, the training core of Tufts Clinical and Translational Science Institute (CTSI), has a long and distinguished history in training leaders in clinical research and CTS. Founded in 1999 as the nation's first clinical research program based at a school of graduate biomedical sciences and an academic medical center, we have continuously evolved to meet the changing needs of CTS training. Now we seek to build on our successful experience to increase our impact preparing the CTS workforce by preparing predoctoral trainees to meet future healthcare challenges. As the world emerges from the COVID-19 pandemic, the case for engaging trainees in CTS research earlier in their careers has never been stronger. While we cannot fully anticipate the specific healthcare challenges that predoctoral trainees will face in the coming decades, we can discern emerging themes that will undoubtedly dominate. For example, it seems certain that future healthcare solutions will increasingly rely on real world evidence emerging from the convergence of machine learning and routinely collected big data. Also, it is abundantly clear from the COVID- 19 pandemic that interactions between humans, animals, and the environment will be a critical, perhaps existential determinant of our health and survival. Finally, while the wealthy appear to be reaching our natural lifespans, durable socioeconomic disparities are estimated to account for roughly one in three premature deaths even in highly developed countries; substantial health gains undoubtedly depend on addressing social determinants of health and other causes of disparity. These concerns, aligned with Tufts' strengths, have shaped our three specialized T32 Program Tracks: Predictive Analytics and Comparative Effectiveness Research (PACER), One Health, and Health Policy and Health Disparities (HPHD). Thus, responding to the call of NCATS to train more predoctoral scholars, we have two principal aims: AIM 1: Inspire and prepare promising professional students as Medical Research Scholars to devote their careers to clinical and translational science. We will provide pathways for professional students (e.g., MD, DVM, DMD, DPT) to augment their clinical education with Certificate, MS, or PhD-level training in CTS. AIM 2: Prepare PhD candidates as Translational Research Scholars to embark on future careers as clinical and translational scientists. We will recruit and train candidates with prior biomedical backgrounds into our CTS PhD program; and provide pathways for doctoral students in related fields (e.g., basic science, computer science, nutrition) to augment their research training with Certificate or MS-level training in CTS.