CTSA Predoctoral T32 at Tufts University

项目摘要 我们建议大幅扩大塔夫茨生物医学研究生院的机会 临床和转化科学(CTS)博士前培训。基于我们最近的集成经验 博士后学生在我们既定的博士后计划中，我们发现早期接触CTS 培训可以深刻地影响学者的职业轨迹，并丰富所有人的学习环境 实习生的级别。塔夫茨临床与翻译专业的核心--塔夫茨CTS研究生项目 科学研究所(CTSI)在培养临床研究和CTS领域的领导者方面有着悠久而杰出的历史。 成立于1999年，是美国第一个以生物医学研究生院为基础的临床研究项目 科学和学术医学中心，我们不断进化，以满足不断变化的CTS需求 训练。现在我们寻求以我们的成功经验为基础，为CTS做准备，以提高我们的影响力 通过培养博士前实习生来应对未来的医疗挑战。随着世界从 新冠肺炎大流行以来，让受训者在职业生涯早期从事CTS研究的理由从未 变得更强大。虽然我们不能完全预测博士后实习生将面临的具体医疗挑战 面对未来几十年，我们可以看到新出现的主题，这些主题无疑将成为主导。例如，它 似乎可以肯定的是，未来的医疗解决方案将越来越依赖于来自 汇聚机器学习，定期收集大数据。此外，从COVID来看，这一点非常清楚- 19大流行认为人类、动物和环境之间的相互作用将是至关重要的，也许 事关我们健康和生存的决定因素。最后，尽管富人似乎正在达到我们的自然状态 寿命、持久的社会经济差距估计约占早产儿的三分之一。 即使在高度发达的国家也是如此；大幅的健康收益无疑取决于解决社会问题 健康的决定因素和造成差异的其他原因。这些担忧与塔夫茨的优势一致， 塑造了我们的三个专业T32计划路径：预测分析和比较有效性 研究(PACER)，One Health，and Health Policy and Health Difference(HPHD)。因此，响应于 NCATS呼吁培养更多的博士前学者，我们有两个主要目标：目标1：启发和准备 有前途的专业学生作为医学研究学者致力于临床和医学 翻译科学。我们将为专业学生(如MD、DVM、DMD、DPT)提供途径 通过CTS的证书、硕士或博士级别的培训来加强他们的临床教育。目标2：准备博士学位 作为翻译研究学者的候选人将开始未来的临床和职业生涯 翻译科学家。我们将招聘和培训具有生物医学背景的候选人进入我们的CTS 博士项目；并为相关领域的博士生(例如，基础科学、计算机)提供途径 科学、营养)，通过CTS证书或MS级别的培训来加强他们的研究培训。

Project Summary We propose to substantially expand opportunities at the Tufts Graduate School of Biomedical Sciences for predoctoral training in clinical and translational science (CTS). Based on our recent experience integrating predoctoral students in our established postdoctoral program, we have found that early exposure to CTS training can profoundly influence the career trajectories of scholars and enrich the learning environment for all levels of trainees. The Tufts CTS Graduate Program, the training core of Tufts Clinical and Translational Science Institute (CTSI), has a long and distinguished history in training leaders in clinical research and CTS. Founded in 1999 as the nation's first clinical research program based at a school of graduate biomedical sciences and an academic medical center, we have continuously evolved to meet the changing needs of CTS training. Now we seek to build on our successful experience to increase our impact preparing the CTS workforce by preparing predoctoral trainees to meet future healthcare challenges. As the world emerges from the COVID-19 pandemic, the case for engaging trainees in CTS research earlier in their careers has never been stronger. While we cannot fully anticipate the specific healthcare challenges that predoctoral trainees will face in the coming decades, we can discern emerging themes that will undoubtedly dominate. For example, it seems certain that future healthcare solutions will increasingly rely on real world evidence emerging from the convergence of machine learning and routinely collected big data. Also, it is abundantly clear from the COVID- 19 pandemic that interactions between humans, animals, and the environment will be a critical, perhaps existential determinant of our health and survival. Finally, while the wealthy appear to be reaching our natural lifespans, durable socioeconomic disparities are estimated to account for roughly one in three premature deaths even in highly developed countries; substantial health gains undoubtedly depend on addressing social determinants of health and other causes of disparity. These concerns, aligned with Tufts' strengths, have shaped our three specialized T32 Program Tracks: Predictive Analytics and Comparative Effectiveness Research (PACER), One Health, and Health Policy and Health Disparities (HPHD). Thus, responding to the call of NCATS to train more predoctoral scholars, we have two principal aims: AIM 1: Inspire and prepare promising professional students as Medical Research Scholars to devote their careers to clinical and translational science. We will provide pathways for professional students (e.g., MD, DVM, DMD, DPT) to augment their clinical education with Certificate, MS, or PhD-level training in CTS. AIM 2: Prepare PhD candidates as Translational Research Scholars to embark on future careers as clinical and translational scientists. We will recruit and train candidates with prior biomedical backgrounds into our CTS PhD program; and provide pathways for doctoral students in related fields (e.g., basic science, computer science, nutrition) to augment their research training with Certificate or MS-level training in CTS.