CTSA Postdoctoral T32 at Tufts University

项目摘要 大力支持生物医学研究培训的理由从未如此强烈。在过去两 多年来，国家的转化研究企业受到了流行病的压力测试，揭示了惊人的 优势和惊人的弱点。虽然未来生物医学和公共卫生挑战的确切性质 虽然我们无法得知，但很明显，国家的安全和福利取决于一个强大的科学家队伍。 拥有多元化的专业知识，在临床和医疗领域的各个领域都接受过良好的核心能力培训 翻译科学（CTS）人们越来越认识到，在其狭窄的领域之外培训研究人员， 科学专业化，包括更多样化的研究和专业技能，特别是那些 与后期转化阶段相关-对于兑现转变人类健康的承诺至关重要， 应对新的挑战。这些领域长期以来一直是塔夫茨临床和 转化科学（CTS）研究生课程，塔夫茨临床和转化科学的培训核心 研究所（CTSI）。我们的硕士/博士课程成立于1999年，是全国第一个临床研究项目 总部设在研究生院生物医学科学和学术医疗中心，我们不断 不断发展以满足CTS培训不断变化的需求。我们的成功是由我们的生产力证明的。 学员，毕业生在研究生涯中的持续高保留率，以及我们杰出的历史， 培养临床研究领导者。这项建议的两个主要目标包括： 目标1：培养下一代早期职业研究人员的批判性思维技能和严谨的 方法，以满足未来几十年的转化科学的挑战。我们将提供 对临床和生物医学研究人员进行CTS核心知识期望的严格培训， 通过利用我们新的和长期的伙伴关系，通过建立和扩大 在我们的MS/PhD研究生课程CTS培训卓越的历史;通过提高三个专业的T32 跟踪，包括预测分析和比较有效性研究（PACER）;一个健康;和 健康政策和健康差距（HPHD）。 目标2：培养早期职业研究人员成为有效的领导者，团队成员，沟通者， 翻译科学的创新者。我们将丰富个性化的指导和研究经验， T32学员通过利用塔夫茨CTSI和合作机构的基础设施， 利益相关者和社区参与、科学传播、团队科学、专业 发展和领导力，严谨和透明度，以及对研究的批判性审查;以及通过策展和 利用塔夫茨CTSI和合作机构的经验机会，重点是 数据科学和信息学，临床试验创新和最佳实践，以及创业和创新。

Project Summary The case for robust support for biomedical research training has never been stronger. During the last two years, the nation’s translational research enterprise was stress tested by a pandemic, revealing both stunning strengths and startling weaknesses. While the precise nature of future biomedical and public health challenges cannot be known, it is clear that the safety and welfare of the country depends on a robust pipeline of scientists with diverse expertise, who are well trained in core competencies across the full spectrum of clinical and translational science (CTS). It is increasingly recognized that training researchers outside of their narrow field of scientific specialization, to include a more varied set of research and professional skills—particularly those related to later translational phases—is critical to deliver on the promise to transform human health and respond to new challenges. These areas have long been signature strengths of the Tufts Clinical and Translational Science (CTS) Graduate Program, the training core of Tufts Clinical and Translational Science Institute (CTSI). Our MS/PhD program was founded in 1999 as the nation’s first clinical research program based at a school of graduate biomedical sciences and an academic medical center and we have continuously evolved to meet the changing needs of CTS training. Our success is evidenced by the productivity of our trainees, the consistently high rate of retention of graduates in research careers, and our outstanding history of training leaders in clinical research. The two principal aims of this proposal include the following: AIM 1: Train the next generation of early career researchers in critical thinking skills and rigorous methodology to meet the translational science challenges of the coming decades. We will provide rigorous training in the core knowledge expectations of CTS to clinical and biomedical research fellows with diverse interests by leveraging our new and longstanding partnerships; by building and expanding upon the history of excellence in CTS training in our MS/PhD Graduate Program; by enhancing three specialized T32 Tracks, including Predictive Analytics and Comparative Effectiveness Research (PACER); One Health; and Health Policy and Health Disparities (HPHD). AIM 2: Prepare early career researchers to be effective leaders, team members, communicators, and innovators in translational science. We will enrich the individualized mentoring and research experiences of the T32 trainees by leveraging the infrastructure of Tufts CTSI and partner institutions to provide supplemental training in stakeholder and community engagement, science communication, team science, professional development and leadership, rigor and transparency, and critical review of research; and by curating and capitalizing on experiential opportunities within the Tufts CTSI and partner institutions, with an emphasis on data science and informatics, clinical trial innovation and best practices, and entrepreneurship and innovation.