Vanderbilt Interdisciplinary Training Program in Alzheimer's Disease

范德比尔特阿尔茨海默病跨学科培训项目

• 批准号: 10873511
• 负责人: ANGELA L. JEFFERSON
• 金额: $ 5.63万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10873511
• 关键词: Alzheimer' s Disease; Training Programs

The proposed T32 program will provide interdisciplinary, translational research training for pre-doctoral students and post-doctoral fellows in Alzheimer's disease (AD) and related neurodegenerative disorders. Leveraging the rich institutional resources of Vanderbilt University and interdisciplinary research strengths of the training faculty, the program will position the next generation of basic, translational, and clinical scientists to advance toward independence while making major contributions to the understanding of AD and its intersection with neurodegeneration and cerebrovascular disease. Through individualized mentorship, integrated curriculum, and involvement in cutting-edge research, the program will emphasize basic science and clinical fundamentals of AD and dementia focusing on (a) cellular stress responses and mechanisms of neuroprotection, (b) hemodynamic and neurovascular mechanisms of injury, (c) cellular regulation and membrane protein function, (d) mechanisms of memory function and dysfunction, (e) discovery and evaluation of therapeutic targets, and (f) clinical manifestations of disease. Trainees will develop essential research skills and professional skills for building a successful career along with a deep appreciation for the responsible conduct of research. Participation in a high quality interdisciplinary research experience will synthesize the trainee's knowledge base, research and professional skill set, and appreciation of research ethics. Each trainee's individualized training plan will be augmented by additional institutional or programmatic didactics and resources to foster academic excellence and scientific innovation during these early, formative periods of professional development.

拟议的T32计划将提供跨学科的，转化研究培训的博士前 阿尔茨海默病（AD）和相关神经退行性疾病的学生和博士后研究员。 利用范德比尔特大学丰富的机构资源和跨学科的研究优势， 培训教师，该计划将定位下一代的基础，翻译和临床科学家， 走向独立，同时为了解AD及其 与神经变性和脑血管疾病交叉。通过个性化的指导， 综合课程，并参与前沿研究，该计划将强调基础科学 AD和痴呆症的临床基础，重点是（a）细胞应激反应和 神经保护，（B）损伤的血液动力学和神经血管机制，（c）细胞调节和 膜蛋白功能，（d）记忆功能和功能障碍的机制，（e）发现和评估 治疗靶点;（f）疾病的临床表现。学员将发展基本的研究技能 和专业技能，以建立一个成功的职业生涯沿着与深刻的赞赏，负责 进行研究。参与高质量的跨学科研究经验将综合 学员的知识基础、研究和专业技能以及对研究道德的欣赏。每个 学员的个性化培训计划将通过额外的机构或方案教学法得到加强， 资源，以促进学术卓越和科学创新，在这些早期，形成时期， 专业发展。