Vanderbilt Alzheimer's Disease Research Center

项目总结--总体 这份P20申请旨在建立探索性的范德比尔特阿尔茨海默病研究中心 (VADRC)在田纳西州纳什维尔的范德比尔特大学医学中心和范德比尔特大学。这个 VADRC将利用范德比尔特记忆和阿尔茨海默氏症的基本要素并在此基础上再接再厉 2012年创建的中心，包括已建立的外展和招聘渠道以及临床， 神经成像、遗传和生物成像数据收集、处理、存储和传播协议。 同时，VADRC将为未来的P30阿尔茨海默氏症建立必要的基础设施 疾病研究中心，专注于识别增加阿尔茨海默病风险的分子因素 或者提高韧性。VADRC的任务将是增强知识，以解决潜在的复杂性 阿尔茨海默病和相关痴呆的病理生理学、早期识别和治疗。我们的 使命和目标与2011年国家阿尔茨海默氏症项目法案保持一致。在P20颁奖期间，我们将建立 管理、临床和生物标记核心协调工作，促进和增强创新的基础、 范德比尔特校园内阿尔茨海默病和相关痴呆症的翻译和临床科学。 这一努力将利用Vanderbilt和Innovative提供的丰富的精准医疗技术和工具 确定新疗法的途径，同时支持教师招聘和留任，整合团队 科学，以及各级的导师关系。P20机制将提供必要的研究资源并促进 一个强大的知识分子社区，支持现有研究并为变革提供新的机会 研究。在临床核心，我们将完成全面的临床，认知，神经成像，遗传学 并对一项新建立的老年人研究队列进行了生物谱评估，研究范围从认知 没有受到轻微阿尔茨海默病的损害，包括在参与者进行尸检时的神经病理分析。 在整个校园内以及与国家知识库(包括 国家阿尔茨海默氏症协调中心)将支持数据收集、共享和传播。这个 VADRC还将加强临床关系、社区伙伴关系和教育机会，以 提高认识，增加研究参与，并提供跨学科的培训环境。这个 该中心将成为阿尔茨海默病所有研究和教育机会的机构中心。 同时，VADRC将为推进阿尔茨海默病研究和临床的国家努力做出贡献 通过与其他阿尔茨海默病研究中心建立关系，开展护理和教育活动， 为国家倡议作出贡献，并加强合作，以最大限度地为实地作出贡献。这个 中心将是该地区第一个此类中心，将有助于为田纳西州不断增长的人口提供服务 以及患有阿尔茨海默氏症和相关痴呆症的南方美国人。

PROJECT SUMMARY – OVERALL This P20 application seeks to establish the Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) at Vanderbilt University Medical Center and Vanderbilt University in Nashville, Tennessee. The VADRC will leverage and build upon the foundational elements of the Vanderbilt Memory and Alzheimer’s Center created in 2012, including established outreach and recruitment pipelines as well as clinical, neuroimaging, genetic, and biospecimen data collection, processing, storage, and dissemination protocols. Simultaneously, the VADRC will establish essential infrastructure appropriate for a future P30 Alzheimer’s Disease Research Center with a focus on identifying molecular factors that increase Alzheimer’s disease risk or promote resilience. The VADRC mission will be to enhance knowledge to solve the complexities underlying the pathophysiology, early identification, and treatment of Alzheimer’s disease and related dementias. Our mission and goals align with the 2011 National Alzheimer’s Project Act. During the P20 award, we will establish Administrative, Clinical, and Biomarker Cores that work in harmony to facilitate and enhance innovative basic, translational, and clinical science in Alzheimer’s disease and related dementia across Vanderbilt’s campus. This effort will leverage rich precision medicine techniques and tools available at Vanderbilt and innovative pathways to identify novel therapeutics while supporting faculty recruitment and retention, integrated team science, and mentorship at all levels. The P20 mechanism will provide essential research resources and foster a strong intellectual community to support existing studies and enable new opportunities for transformative research. Within the Clinical Core, we will complete comprehensive clinical, cognitive, neuroimaging, genetic and biospecimen assessment on a newly established research cohort of aging adults ranging from cognitively unimpaired to mild Alzheimer’s disease, including neuropathological analyses as participants come to autopsy. Cross-Core and interdisciplinary collaborations throughout campus and with national repositories (including the National Alzheimer’s Coordinating Center) will support data collection, sharing, and dissemination. The VADRC will also enhance clinical relationships, community partnerships, and educational opportunities to promote awareness, increase research participation, and provide an interdisciplinary training environment. The Center will serve as the institutional hub of all research and educational opportunities in Alzheimer’s disease. Simultaneously, the VADRC will contribute to national efforts to advance Alzheimer’s disease research, clinical care, and educational activities by establishing relationships with other Alzheimer’s Disease Research Centers, contributing to national initiatives, and enhancing collaborations to maximize contributions to the field. The Center will be the first of its kind in the region and would help to serve the growing population of Tennesseans and southern Americans suffering from Alzheimer’s disease and related dementias.