Vanderbilt Alzheimer's Disease Research Center

范德比尔特阿尔茨海默病研究中心

• 批准号: 10038234
• 负责人: ANGELA L. JEFFERSON
• 金额: $ 123.39万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10038234
• 关键词: Academic Medical Centers; Adult; African American; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer' s disease therapeutic; American; Autopsy; Award; Awareness; Basic Science; Biological Markers; Cerebrovascular Disorders; Clinical; Clinical Sciences; Clinical Trials; Cognitive; Collaborations; Communities; Data; Data Collection; Data Set; Dementia; Development; Early identification; Educational Activities; Educational Curriculum; Educational workshop; Elderly; Elements; Enrollment; Environment; Faculty Recruitment; Fostering; Foundations; Functional disorder; Funding; Future; Genetic; Goals; Grant; Growth; High Prevalence; Incidence; Infrastructure; Injury; Institution; Intervention; Knowledge; Memory; Mentorship; Mission; Molecular; Participant; Pathway interactions; Phenotype; Population; Positioning Attribute; Postdoctoral Fellow; Prevention; Prevention strategy; Protocols documentation; Relationship-Building; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Science; Scientist; Strategic Planning; Students; Techniques; Technology; Tennessee; Training; Translating; Translational Research; Universities; Work; bench to bedside; clinical biomarkers; clinical care; clinical practice; cohesion; cohort; community partnership; cooperative study; data acquisition; dementia risk; early-career faculty; faculty support; imaging genetics; innovation; interdisciplinary collaboration; neuroimaging; next generation; novel therapeutics; outreach; precision medicine; programs; ranpirnase; recruit; repository; resilience; symposium; tool; training opportunity; treatment strategy; vascular injury

PROJECT SUMMARY – OVERALL This P20 application seeks to establish the Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) at Vanderbilt University Medical Center and Vanderbilt University in Nashville, Tennessee. The VADRC will leverage and build upon the foundational elements of the Vanderbilt Memory and Alzheimer’s Center created in 2012, including established outreach and recruitment pipelines as well as clinical, neuroimaging, genetic, and biospecimen data collection, processing, storage, and dissemination protocols. Simultaneously, the VADRC will establish essential infrastructure appropriate for a future P30 Alzheimer’s Disease Research Center with a focus on identifying molecular factors that increase Alzheimer’s disease risk or promote resilience. The VADRC mission will be to enhance knowledge to solve the complexities underlying the pathophysiology, early identification, and treatment of Alzheimer’s disease and related dementias. Our mission and goals align with the 2011 National Alzheimer’s Project Act. During the P20 award, we will establish Administrative, Clinical, and Biomarker Cores that work in harmony to facilitate and enhance innovative basic, translational, and clinical science in Alzheimer’s disease and related dementia across Vanderbilt’s campus. This effort will leverage rich precision medicine techniques and tools available at Vanderbilt and innovative pathways to identify novel therapeutics while supporting faculty recruitment and retention, integrated team science, and mentorship at all levels. The P20 mechanism will provide essential research resources and foster a strong intellectual community to support existing studies and enable new opportunities for transformative research. Within the Clinical Core, we will complete comprehensive clinical, cognitive, neuroimaging, genetic and biospecimen assessment on a newly established research cohort of aging adults ranging from cognitively unimpaired to mild Alzheimer’s disease, including neuropathological analyses as participants come to autopsy. Cross-Core and interdisciplinary collaborations throughout campus and with national repositories (including the National Alzheimer’s Coordinating Center) will support data collection, sharing, and dissemination. The VADRC will also enhance clinical relationships, community partnerships, and educational opportunities to promote awareness, increase research participation, and provide an interdisciplinary training environment. The Center will serve as the institutional hub of all research and educational opportunities in Alzheimer’s disease. Simultaneously, the VADRC will contribute to national efforts to advance Alzheimer’s disease research, clinical care, and educational activities by establishing relationships with other Alzheimer’s Disease Research Centers, contributing to national initiatives, and enhancing collaborations to maximize contributions to the field. The Center will be the first of its kind in the region and would help to serve the growing population of Tennesseans and southern Americans suffering from Alzheimer’s disease and related dementias.

项目概要-总体 此P20申请旨在建立探索性范德比尔特阿尔茨海默病研究中心 （VADRC）在范德比尔特大学医学中心和范德比尔特大学在纳什维尔，田纳西州。的 VADRC将利用和建立在范德比尔特记忆和阿尔茨海默氏症的基本要素 中心成立于2012年，包括建立外展和招聘渠道以及临床， 神经成像、遗传和生物样本数据收集、处理、存储和传播协议。 同时，VADRC将建立适合未来P30阿尔茨海默氏症的必要基础设施 疾病研究中心，重点是确定增加阿尔茨海默病风险的分子因素 或促进恢复力。VADRC的使命将是增强知识以解决潜在的复杂性 阿尔茨海默病及相关痴呆的病理生理学、早期识别和治疗。我们 使命和目标与2011年国家阿尔茨海默病项目法案一致。在P20颁奖期间，我们将建立 行政、临床和生物标志物核心协调工作，促进和加强创新的基础， 在范德比尔特的校园里，阿尔茨海默病和相关痴呆症的转化和临床科学。 这项工作将利用范德比尔特丰富的精确医学技术和工具， 途径，以确定新的疗法，同时支持教师招聘和保留，综合团队 科学和各级指导。P20机制将提供必要的研究资源， 一个强大的知识界，以支持现有的研究，并使新的机会，变革 research.在临床核心中，我们将完成全面的临床，认知，神经影像学，遗传学， 和生物标本评估对一个新建立的研究队列的老年人，从认知 未受损的轻度阿尔茨海默病，包括参与者尸检时的神经病理学分析。 跨核心和跨学科的合作，整个校园和国家知识库（包括 国家阿尔茨海默氏症协调中心）将支持数据收集、共享和传播。的 VADRC还将加强临床关系，社区合作伙伴关系和教育机会， 提高认识，增加研究参与，并提供跨学科的培训环境。的 该中心将作为阿尔茨海默病所有研究和教育机会的机构中心。 与此同时，VADRC将为推进阿尔茨海默病研究、临床和治疗的国家努力做出贡献。 通过与其他阿尔茨海默病研究中心建立关系，开展护理和教育活动， 为国家举措作出贡献，并加强合作，以最大限度地为实地作出贡献。的 该中心将是该地区第一个此类中心，将有助于为不断增长的田纳西州人口提供服务 以及患有阿尔茨海默氏症和相关痴呆症的美国南部人。