Vanderbilt Alzheimer's Disease Research Center

范德比尔特阿尔茨海默病研究中心

基本信息

批准号：
10470722
负责人：
ANGELA L. JEFFERSON
金额：
$ 168.97万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10470722
关键词：
Academic Medical Centers Adult African American African American population Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer&apos s disease therapeutic American Autopsy Award Awareness Basic Science Biological Markers Cerebrovascular Disorders Clinical Clinical Sciences Clinical Trials Cognitive Collaborations Communities Data Data Collection Data Set Dementia Development Early identification Educational Activities Educational Curriculum Educational workshop Elderly Elements Enrollment Environment Faculty Recruitment Fostering Foundations Functional disorder Funding Future Genetic Goals Grant Growth High Prevalence Incidence Infrastructure Injury Institution Intervention Knowledge Memory Mentorship Mission Molecular Participant Pathway interactions Phenotype Population Positioning Attribute Postdoctoral Fellow Prevention Prevention strategy Protocols documentation Relationship-Building Research Research Activity Research Infrastructure Research Institute Research Personnel Research Project Grants Resources Science Scientist Strategic Planning Students Techniques Technology Tennessee Training Translating Translational Research Universities Work bench to bedside clinical biomarkers clinical care clinical practice cohesion cohort community engagement community partnership cooperative study data acquisition dementia risk early-career faculty faculty support imaging genetics innovation interdisciplinary collaboration neuroimaging next generation novel therapeutics outreach precision medicine programs ranpirnase recruit repository resilience symposium tool training opportunity treatment strategy vascular injury

项目摘要

PROJECT SUMMARY – OVERALL This P20 application seeks to establish the Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) at Vanderbilt University Medical Center and Vanderbilt University in Nashville, Tennessee. The VADRC will leverage and build upon the foundational elements of the Vanderbilt Memory and Alzheimer’s Center created in 2012, including established outreach and recruitment pipelines as well as clinical, neuroimaging, genetic, and biospecimen data collection, processing, storage, and dissemination protocols. Simultaneously, the VADRC will establish essential infrastructure appropriate for a future P30 Alzheimer’s Disease Research Center with a focus on identifying molecular factors that increase Alzheimer’s disease risk or promote resilience. The VADRC mission will be to enhance knowledge to solve the complexities underlying the pathophysiology, early identification, and treatment of Alzheimer’s disease and related dementias. Our mission and goals align with the 2011 National Alzheimer’s Project Act. During the P20 award, we will establish Administrative, Clinical, and Biomarker Cores that work in harmony to facilitate and enhance innovative basic, translational, and clinical science in Alzheimer’s disease and related dementia across Vanderbilt’s campus. This effort will leverage rich precision medicine techniques and tools available at Vanderbilt and innovative pathways to identify novel therapeutics while supporting faculty recruitment and retention, integrated team science, and mentorship at all levels. The P20 mechanism will provide essential research resources and foster a strong intellectual community to support existing studies and enable new opportunities for transformative research. Within the Clinical Core, we will complete comprehensive clinical, cognitive, neuroimaging, genetic and biospecimen assessment on a newly established research cohort of aging adults ranging from cognitively unimpaired to mild Alzheimer’s disease, including neuropathological analyses as participants come to autopsy. Cross-Core and interdisciplinary collaborations throughout campus and with national repositories (including the National Alzheimer’s Coordinating Center) will support data collection, sharing, and dissemination. The VADRC will also enhance clinical relationships, community partnerships, and educational opportunities to promote awareness, increase research participation, and provide an interdisciplinary training environment. The Center will serve as the institutional hub of all research and educational opportunities in Alzheimer’s disease. Simultaneously, the VADRC will contribute to national efforts to advance Alzheimer’s disease research, clinical care, and educational activities by establishing relationships with other Alzheimer’s Disease Research Centers, contributing to national initiatives, and enhancing collaborations to maximize contributions to the field. The Center will be the first of its kind in the region and would help to serve the growing population of Tennesseans and southern Americans suffering from Alzheimer’s disease and related dementias.

项目摘要 - 总体该P20申请旨在建立探索性范德比尔特阿尔茨海默氏病研究中心（VADRC）在田纳西州纳什维尔的范德比尔特大学医学中心和范德比尔特大学。这 VADRC将利用并建立在Vanderbilt Memory和Alzheimer的基础元素上 2012年创建的中心，包括既定的外展和招聘管道以及临床，神经影像，遗传和生物测量数据收集，处理，存储和传播方案。同时，VADRC将建立适合未来P30 Alzheimer的基础设施疾病研究中心的重点是识别增加阿尔茨海默氏病风险的分子因素或促进弹性。 VADRC任务将是增强知识以解决基本的复杂性阿尔茨海默氏病和相关痴呆症的病理生理学，早期鉴定和治疗。我们的任务和目标与2011年国家阿尔茨海默氏症的项目法案保持一致。在P20奖中，我们将建立行政，临床和生物标志物核心，可协调并增强创新基本的工作，范德比尔特校园中的阿尔茨海默氏病和相关痴呆症的翻译和临床科学。这项工作将利用范德比尔特提供的丰富精密医学技术和工具在支持教师招聘和保留的同时识别新疗法的途径，综合团队科学和各个层面的精神训练。 P20机制将提供基本的研究资源并培养一个强大的知识分子社区，以支持现有研究并为变革性带来新的机会研究。在临床核心内，我们将完成全面的临床，认知，神经影像学，遗传以及对新成立的老年人研究队列的生物测量评估，从认知上随着参与者进行尸检，包括神经病理学分析，包括神经病理分析。整个校园以及与国家存储库的跨核和跨学科合作（包括国家阿尔茨海默氏症的协调中心）将支持数据收集，共享和传播。这 VADRC还将增强临床关系，社区伙伴关系和教育机会促进意识，提高研究参与并提供跨学科的培训环境。中心将成为阿尔茨海默氏病的所有研究和教育机会的机构中心。同时，VADRC将有助于国家努力推进阿尔茨海默氏病研究，临床通过与其他阿尔茨海默氏病研究中心建立关系，护理和教育活动，为国家倡议做出贡献，并加强合作，以最大程度地提高对该领域的贡献。中心将是该地区的第一个同类产品，将有助于为田纳西州不断增长的人口提供服务以及患有阿尔茨海默氏病和相关痴呆症的南部美国人。