权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Vanderbilt Alzheimer's Disease Research Center

范德比尔特阿尔茨海默病研究中心

基本信息

批准号：
10876856
负责人：
ANGELA L. JEFFERSON
金额：
$ 98.38万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10876856
关键词：
Academic Medical Centers Adult African American African American population Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer&apos s disease therapeutic American Autopsy Award Awareness Basic Science Biological Markers Cerebrovascular Disorders Clinical Clinical Sciences Clinical Trials Cognitive Collaborations Communities Data Data Collection Data Set Dementia Development Early identification Education Educational Activities Educational Curriculum Educational workshop Elderly Elements Enrollment Environment Faculty Recruitment Fostering Functional disorder Funding Future Genetic Goals Grant Growth High Prevalence Image Incidence Infrastructure Injury Institution Intervention Knowledge Memory Mentorship Mission Molecular Participant Pathway interactions Phenotype Population Positioning Attribute Postdoctoral Fellow Prevention Prevention strategy Protocols documentation Research Research Activity Research Infrastructure Research Institute Research Personnel Research Project Grants Resources Science Scientist Site Strategic Planning Students Techniques Technology Tennessee Training Translating Translational Research Universities Work bench to bedside clinical care clinical practice cohort community engagement community partnership cooperative study data acquisition dementia risk early-career faculty faculty support innovation interdisciplinary collaboration neuroimaging neuropathology next generation novel therapeutics outreach precision medicine programs promote resilience recruit repository symposium tool training opportunity treatment strategy vascular injury

项目摘要

PROJECT SUMMARY – OVERALL This P20 application seeks to establish the Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) at Vanderbilt University Medical Center and Vanderbilt University in Nashville, Tennessee. The VADRC will leverage and build upon the foundational elements of the Vanderbilt Memory and Alzheimer’s Center created in 2012, including established outreach and recruitment pipelines as well as clinical, neuroimaging, genetic, and biospecimen data collection, processing, storage, and dissemination protocols. Simultaneously, the VADRC will establish essential infrastructure appropriate for a future P30 Alzheimer’s Disease Research Center with a focus on identifying molecular factors that increase Alzheimer’s disease risk or promote resilience. The VADRC mission will be to enhance knowledge to solve the complexities underlying the pathophysiology, early identification, and treatment of Alzheimer’s disease and related dementias. Our mission and goals align with the 2011 National Alzheimer’s Project Act. During the P20 award, we will establish Administrative, Clinical, and Biomarker Cores that work in harmony to facilitate and enhance innovative basic, translational, and clinical science in Alzheimer’s disease and related dementia across Vanderbilt’s campus. This effort will leverage rich precision medicine techniques and tools available at Vanderbilt and innovative pathways to identify novel therapeutics while supporting faculty recruitment and retention, integrated team science, and mentorship at all levels. The P20 mechanism will provide essential research resources and foster a strong intellectual community to support existing studies and enable new opportunities for transformative research. Within the Clinical Core, we will complete comprehensive clinical, cognitive, neuroimaging, genetic and biospecimen assessment on a newly established research cohort of aging adults ranging from cognitively unimpaired to mild Alzheimer’s disease, including neuropathological analyses as participants come to autopsy. Cross-Core and interdisciplinary collaborations throughout campus and with national repositories (including the National Alzheimer’s Coordinating Center) will support data collection, sharing, and dissemination. The VADRC will also enhance clinical relationships, community partnerships, and educational opportunities to promote awareness, increase research participation, and provide an interdisciplinary training environment. The Center will serve as the institutional hub of all research and educational opportunities in Alzheimer’s disease. Simultaneously, the VADRC will contribute to national efforts to advance Alzheimer’s disease research, clinical care, and educational activities by establishing relationships with other Alzheimer’s Disease Research Centers, contributing to national initiatives, and enhancing collaborations to maximize contributions to the field. The Center will be the first of its kind in the region and would help to serve the growing population of Tennesseans and southern Americans suffering from Alzheimer’s disease and related dementias.

PROJECT SUMMARY – OVERALL 该 P20 申请旨在建立探索性范德比尔特阿尔茨海默病研究中心（VADRC）在范德比尔特大学医学中心和田纳西州纳什维尔的范德比尔特大学。这 VADRC will leverage and build upon the foundational elements of the Vanderbilt Memory and Alzheimer’s Center created in 2012, including established outreach and recruitment pipelines as well as clinical, 神经影像、遗传和生物样本数据收集、处理、存储和传播协议。同时，VADRC 将建立适合未来 P30 阿尔茨海默病的必要基础设施疾病研究中心专注于识别增加阿尔茨海默病风险的分子因素或提高复原力。 VADRC 的使命是增强知识以解决潜在的复杂性阿尔茨海默病和相关痴呆症的病理生理学、早期识别和治疗。我们的 mission and goals align with the 2011 National Alzheimer’s Project Act. During the P20 award, we will establish 行政、临床和生物标志物核心协调一致，促进和增强创新基础、 translational, and clinical science in Alzheimer’s disease and related dementia across Vanderbilt’s campus. This effort will leverage rich precision medicine techniques and tools available at Vanderbilt and innovative pathways to identify novel therapeutics while supporting faculty recruitment and retention, integrated team science, and mentorship at all levels. The P20 mechanism will provide essential research resources and foster 一个强大的知识界来支持现有的研究并为变革提供新的机会研究。在临床核心中，我们将完成全面的临床、认知、神经影像、遗传 and biospecimen assessment on a newly established research cohort of aging adults ranging from cognitively 未受到轻度阿尔茨海默病的影响，包括参与者进行尸检时的神经病理学分析。 Cross-Core and interdisciplinary collaborations throughout campus and with national repositories (including the National Alzheimer’s Coordinating Center) will support data collection, sharing, and dissemination.这 VADRC 还将加强临床关系、社区伙伴关系和教育机会，提高认识、增加研究参与并提供跨学科培训环境。这 Center will serve as the institutional hub of all research and educational opportunities in Alzheimer’s disease. Simultaneously, the VADRC will contribute to national efforts to advance Alzheimer’s disease research, clinical care, and educational activities by establishing relationships with other Alzheimer’s Disease Research Centers, contributing to national initiatives, and enhancing collaborations to maximize contributions to the field.这 Center will be the first of its kind in the region and would help to serve the growing population of Tennesseans and southern Americans suffering from Alzheimer’s disease and related dementias.