Admin Core

管理核心

基本信息

批准号：
10909442
负责人：
ANGELA L. JEFFERSON
金额：
$ 31.04万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10909442
关键词：
Academic Medical Centers Advisory Committees Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease therapeutic Alzheimer&apos s disease therapy Basic Science Biological Markers Clinical Clinical Research Clinical and Translational Science Awards Collaborations Data Development Discipline Disease Pathway Educational workshop Ensure Evaluation Event Faculty Fostering Funding Future Genetic Goals Grant Growth Health Historically Black Colleges and Universities Individual Infrastructure Injury Institution Investigator-Initiated Research Leadership Link Memory Mission Multi-Institutional Clinical Trial National Institute on Aging Outcome Participant Pathway interactions Policies Positioning Attribute Principal Investigator Protocols documentation Research Research Activity Research Institute Research Personnel Research Training Resource Sharing Resources Science Scientist Site Strategic Planning Structure Techniques Training Activity Translational Research Universities career cohort cooperative study data exchange data management data sharing data storage site early-career faculty graduate student health equity improved medical schools medical specialties meetings neuroimaging next generation novel operation pharmacologic programs repository sharing platform training opportunity undergraduate student vascular contributions

项目摘要

PROJECT SUMMARY – ADMINISTRATIVE CORE The Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) Administrative Core is central to achieving the overall mission of the VADRC and will leverage strong institutional resources to provide excellent administrative oversight for a scalable infrastructure to position Vanderbilt University Medical Center and Vanderbilt University for a future successful P30 application. Under the proven leadership of Dr. Angela Jefferson, supported by Associate Directors, Dr. Consuelo Wilkins and Dr. Charles Sanders, the Administrative Core is uniquely positioned to achieve this goal. Our interdisciplinary Core leadership will ensure that all programmatic objectives of the VADRC are accomplished by coordinating and integrating VADRC Cores and scaling these Center functions into a thriving P30-funded ADRC. Core leadership will drive the Center’s scientific direction emphasizing non-amyloid pathways of injury, including understanding vascular contributions to Alzheimer’s disease and related dementias, discovering novel disease pathways using advanced techniques, and improving pharmacological therapies for Alzheimer’s disease and related dementias. The Administrative Core will serve as the institutional hub for all local Alzheimer’s disease research activities by providing strategic planning, scientific direction, campus-wide integration, and essential infrastructure. Core leadership will identify opportunities for growth while harnessing strengths of existing programs. The Administrative Core will establish and facilitate administrative structure, Center governance, and oversight for Center operations. These functions include managing budgetary oversight, ensuring compliance with regulatory requirements, facilitating ongoing internal and external review and evaluation of VADRC activities, and coordinating fiscal, operational, and regulatory functions to ensure effective utilization of Center resources. The Administrative Core will actively support local research activities and contribute to collaborative national research initiatives and resource sharing to advance the goals of the National Alzheimer’s Project Act. Leadership will establish a scalable data sharing platform to support a future P30 Data Management and Statistical Core. Such infrastructure will promote coordinating and integrating VADRC activities for data transfer that serve local investigator needs and support national research efforts (e.g., National Alzheimer’s Coordinating Center, National Centralized Repository for Alzheimer’s Disease and Related Dementias). Additionally, the Administrative Core will support VADRC participation in multi-site clinical trials. Finally, the Core will be integral in fostering professional development of the next generation of clinicians and scientists in Alzheimer’s disease. Collectively, the VADRC Administrative Core will be instrumental in establishing and facilitating harmonized integration between all Center investigators, collaborators, Core functions, institutional resources, and national partners, which will facilitate a smooth transition to a future P30-funded VADRC.

项目摘要 - 行政核心探索性范德比尔特阿尔茨海默氏病研究中心（VADRC）行政核心是实现VADRC的整体使命，并将利用强大的机构资源来提供优秀可扩展基础设施的行政监督，以定位范德比尔特大学医学中心和范德比尔特大学未来成功的P30申请。在安吉拉博士的可靠领导下杰斐逊（Jefferson 核心是实现这一目标的独特位置。我们的跨学科核心领导将确保所有人 VADRC的程序化目标是通过坐标和集成VADRC内核来实现的将这些中心功能缩放到蓬勃发展的P30资助的ADRC中。核心领导将推动中心的科学方向强调非淀粉样损伤途径，包括了解血管贡献为阿尔茨海默氏病和相关痴呆症，使用先进的疾病途径发现了新的疾病途径技术和改善阿尔茨海默氏病和相关痴呆症的药物疗法。行政核心将作为所有当地阿尔茨海默氏病研究活动的机构中心提供战略规划，科学方向，整个校园整合和基本基础设施。核领导力将确定增长的机会，同时利用现有计划的优势。这行政核心将建立并促进行政结构，中心治理和监督中心操作。这些功能包括管理预算监督，确保遵守监管要求，支持正在进行的内部和外部审查以及对VADRC活动的评估，并协调财政，运营和监管功能，以确保有效利用中心资源。行政核心将积极支持当地研究活动，并为协作国家做出贡献研究计划和资源共享，以促进《国家阿尔茨海默氏症》项目法案的目标。领导力将建立一个可扩展的数据共享平台，以支持未来的P30数据管理和统计核心。这种基础设施将促进协调和整合数据的活动适应当地研究者需求并支持国家研究工作的转会（例如，国家阿尔茨海默氏症阿尔茨海默氏病和相关痴呆症的国家集中库协调中心。此外，行政核心将支持VADRC参与多站点临床试验。最后，核心将在促进下一代临床医生和科学家的专业发展中不可或缺阿尔茨海默氏病。总体而言，VADRC行政核心将有助于建立和促进所有中心研究人员，合作者，核心职能，机构之间的统一整合资源和国家合作伙伴，这将促进向未来P30资助的VADRC的平稳过渡。