Risk factors and prevention targets for abnormal cognitive aging
认知老化异常的危险因素及预防目标
基本信息
- 批准号:10542371
- 负责人:
- 金额:$ 17.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAccelerationAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAlzheimer&aposs disease related dementiaAlzheimer’s disease biomarkerAmyloidAmyloid beta-42Amyloid beta-ProteinAmyloidosisAortaAwardBiological MarkersBlood VesselsBrainCardiacCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCerebrospinal FluidCerebrovascular CirculationCerebrovascular DisordersClinicalClinical ResearchCognitiveCognitive agingDataDementiaDisease OutcomeEFRACElderlyEnvironmentExtracellular MatrixFunctional disorderFundingFunding OpportunitiesGoalsHealthHumanImpaired cognitionInjuryInstructionInterdisciplinary StudyInvestigationKnowledgeLightMass Spectrum AnalysisMediatingMedical StudentsMemoryMentorsMentorshipMethodsMicrocirculationMicrogliaMicrovascular DysfunctionMidcareer Investigator Award in Patient-Oriented ResearchMolecularNerve DegenerationNeurofibrillary TanglesNeurologyNeuronal InjuryNeuropsychologyOutcomePathogenesisPathologicPathologic ProcessesPathologyPathway interactionsPhysiologic pulsePlayPositioning AttributePostdoctoral FellowPredisposing FactorPreventionPrevention strategyProductivityProfessional EducationProteomicsPublic HealthPublicationsResearchResearch PersonnelResearch Project GrantsResourcesRiskRisk FactorsRoleScientific Advances and AccomplishmentsStructureSynapsesTechnologyThinnessTimeTrainingTranslational ResearchUnited States National Institutes of HealthVascular DiseasesWorkaging brainaxon injurybrain abnormalitiesbrain healthbrain volumecareercerebral hemodynamicscerebrovascularcerebrovascular pathologycognitive performancedata infrastructuredementia riskearly-career facultyglial activationgraduate studenthemodynamicsindexinginnovationinsightinterestmolecular markerneurofilamentneuroimagingneuroimaging markernext generationnovelpatient orientedpatient oriented researchpreventprofessorprogramsskillstau Proteinstau-1therapeutic targettoolundergraduate studentvascular risk factorwhite matter
项目摘要
This proposal is requesting a one-time renewal of a Midcareer Investigator Award in Patient-Oriented
Research (K24). The candidate, Dr. Angela Jefferson, is a neuropsychologist whose interdisciplinary research
program focuses on understanding the impact of cardiovascular and cerebrovascular integrity on the
pathogenesis and clinical manifestation of Alzheimer's disease and small vessel disease. Dr. Jefferson is a
Professor of Neurology at Vanderbilt University Medical Center and founding Director of the Vanderbilt Memory
& Alzheimer's Center. Since completing her training 13 years ago, Dr. Jefferson has established herself as a
productive clinical researcher with strong NIH funding and a high-impact, prolific publication record. Over the
last decade, including the original K24 funding period (2013-2018), she has demonstrated a strong
commitment to professional education and mentorship. This K24 renewal will be instrumental in continuing to
provide protected time for Dr. Jefferson to expand her clinical research capabilities. In particular, she will
expand her expertise in cerebrospinal fluid biomarkers of Alzheimer's disease to include innovative molecular
biomarkers reflecting concomitant pathways, such as extracellular matrix remodeling, microglial activation, and
synaptic dysfunction. She will also expand the breadth of proteomic biomarkers at her disposal by leveraging
state of the art discovery-based mass spectrometry methods. These tools will substantially enrich our
understanding of the mechanisms by which compromised vascular health relates to abnormal brain aging and
inform strategies to prevent or delay the pathological cascade associated with cognitive impairment and
dementia. Furthermore, the proposed award will allow Dr. Jefferson to continue to use her research program
as a platform to mentor early career investigators, including undergraduate, graduate, and medical students;
postdoctoral fellows; and early career faculty in patient-oriented research in cognitive aging, Alzheimer's
disease, and small vessel disease. This proposal integrates Dr. Jefferson's interdisciplinary research team and
resources available through the Vanderbilt Memory & Alzheimer's Center and Vanderbilt Institute for Clinical
and Translational Research to offer a rich training environment for mentees. The training and research
facilitated by this K24 mechanism renewal will not only advance knowledge regarding cardiovascular and
cerebrovascular pathways contributing to the pathogenesis and clinical manifestation of Alzheimer's disease
and small vessel disease, but it will also develop a cadre of next-generation cognitive aging researchers well-
positioned to make meaningful contributions to the field.
这项提案要求一次性续签以患者为中心的职业生涯中期调查员奖
研究(K24)。候选人安吉拉·杰斐逊博士是一位神经心理学家,他的跨学科研究
该计划侧重于了解心脑血管完整性对
阿尔茨海默病和小血管病的发病机制和临床表现。杰斐逊博士是一位
范德比尔特大学医学中心神经学教授,范德比尔特记忆创始主任
&阿尔茨海默氏症中心。自从13年前完成训练以来,杰斐逊博士已经确立了自己的地位
富有成效的临床研究人员,拥有强大的NIH资金和高影响力、多产的出版记录。超过了
在过去的十年里,包括最初的K24资助期(2013-2018),她展示了强大的
致力于专业教育和指导。此次K24续订将有助于继续
为杰斐逊博士扩大临床研究能力提供有保障的时间。尤其是,她会
扩展她在阿尔茨海默病脑脊液生物标记物方面的专业知识,以包括创新的分子
反映伴随途径的生物标记物,如细胞外基质重塑、小胶质细胞激活和
突触功能障碍。她还将扩大蛋白质组生物标记物的范围,通过利用
最新的基于发现的质谱学方法。这些工具将大大丰富我们的
了解血管健康受损与异常脑老化和
提供预防或延缓与认知障碍相关的病理性级联的策略
痴呆症。此外,拟议的奖励将允许杰斐逊博士继续使用她的研究项目
作为指导早期职业调查人员的平台,包括本科生、研究生和医学生;
博士后研究员;阿尔茨海默氏症认知老化患者导向研究的早期职业教师
疾病和小血管疾病。这项提议整合了杰斐逊博士的跨学科研究团队和
范德比尔特记忆与阿尔茨海默氏症中心和范德比尔特临床研究所提供的资源
和翻译研究,为学员提供丰富的培训环境。培训和研究
在K24机制的推动下,更新不仅将促进对心血管和
阿尔茨海默病发病机制及临床表现的脑血管通路
和小血管疾病,但它也将很好地培养一批下一代认知老化研究人员-
定位于为该领域做出有意义的贡献。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANGELA L. JEFFERSON其他文献
ANGELA L. JEFFERSON的其他文献
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{{ truncateString('ANGELA L. JEFFERSON', 18)}}的其他基金
Vanderbilt Alzheimer's Disease Research Center
范德比尔特阿尔茨海默病研究中心
- 批准号:
10038234 - 财政年份:2020
- 资助金额:
$ 17.86万 - 项目类别:
Vanderbilt Alzheimer's Disease Research Center
范德比尔特阿尔茨海默病研究中心
- 批准号:
10876856 - 财政年份:2020
- 资助金额:
$ 17.86万 - 项目类别:
Vanderbilt Alzheimer's Disease Research Center
范德比尔特阿尔茨海默病研究中心
- 批准号:
10229538 - 财政年份:2020
- 资助金额:
$ 17.86万 - 项目类别:
Vanderbilt Alzheimer's Disease Research Center
范德比尔特阿尔茨海默病研究中心
- 批准号:
10374437 - 财政年份:2020
- 资助金额:
$ 17.86万 - 项目类别:
Vanderbilt Alzheimer's Disease Research Center
范德比尔特阿尔茨海默病研究中心
- 批准号:
10470722 - 财政年份:2020
- 资助金额:
$ 17.86万 - 项目类别:
Vanderbilt Interdisciplinary Training Program in Alzheimer's Disease
范德比尔特阿尔茨海默病跨学科培训项目
- 批准号:
10873511 - 财政年份:2018
- 资助金额:
$ 17.86万 - 项目类别:
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