Risk factors and prevention targets for abnormal cognitive aging

认知老化异常的危险因素及预防目标

• 批准号: 10542371
• 负责人: ANGELA L. JEFFERSON
• 金额: $ 17.86万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10542371
• 关键词: Academic Medical Centers; Acceleration; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-42; Amyloid beta-Protein; Amyloidosis; Aorta; Award; Biological Markers; Blood Vessels; Brain; Cardiac; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cerebrospinal Fluid; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical; Clinical Research; Cognitive; Cognitive aging; Data; Dementia; Disease Outcome; EFRAC; Elderly; Environment; Extracellular Matrix; Functional disorder; Funding; Funding Opportunities; Goals; Health; Human; Impaired cognition; Injury; Instruction; Interdisciplinary Study; Investigation; Knowledge; Light; Mass Spectrum Analysis; Mediating; Medical Students; Memory; Mentors; Mentorship; Methods; Microcirculation; Microglia; Microvascular Dysfunction; Midcareer Investigator Award in Patient-Oriented Research; Molecular; Nerve Degeneration; Neurofibrillary Tangles; Neurology; Neuronal Injury; Neuropsychology; Outcome; Pathogenesis; Pathologic; Pathologic Processes; Pathology; Pathway interactions; Physiologic pulse; Play; Positioning Attribute; Postdoctoral Fellow; Predisposing Factor; Prevention; Prevention strategy; Productivity; Professional Education; Proteomics; Public Health; Publications; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Scientific Advances and Accomplishments; Structure; Synapses; Technology; Thinness; Time; Training; Translational Research; United States National Institutes of Health; Vascular Diseases; Work; aging brain; axon injury; brain abnormalities; brain health; brain volume; career; cerebral hemodynamics; cerebrovascular; cerebrovascular pathology; cognitive performance; data infrastructure; dementia risk; early-career faculty; glial activation; graduate student; hemodynamics; indexing; innovation; insight; interest; molecular marker; neurofilament; neuroimaging; neuroimaging marker; next generation; novel; patient oriented; patient oriented research; prevent; professor; programs; skills; tau Proteins; tau-1; therapeutic target; tool; undergraduate student; vascular risk factor; white matter

This proposal is requesting a one-time renewal of a Midcareer Investigator Award in Patient-Oriented Research (K24). The candidate, Dr. Angela Jefferson, is a neuropsychologist whose interdisciplinary research program focuses on understanding the impact of cardiovascular and cerebrovascular integrity on the pathogenesis and clinical manifestation of Alzheimer's disease and small vessel disease. Dr. Jefferson is a Professor of Neurology at Vanderbilt University Medical Center and founding Director of the Vanderbilt Memory & Alzheimer's Center. Since completing her training 13 years ago, Dr. Jefferson has established herself as a productive clinical researcher with strong NIH funding and a high-impact, prolific publication record. Over the last decade, including the original K24 funding period (2013-2018), she has demonstrated a strong commitment to professional education and mentorship. This K24 renewal will be instrumental in continuing to provide protected time for Dr. Jefferson to expand her clinical research capabilities. In particular, she will expand her expertise in cerebrospinal fluid biomarkers of Alzheimer's disease to include innovative molecular biomarkers reflecting concomitant pathways, such as extracellular matrix remodeling, microglial activation, and synaptic dysfunction. She will also expand the breadth of proteomic biomarkers at her disposal by leveraging state of the art discovery-based mass spectrometry methods. These tools will substantially enrich our understanding of the mechanisms by which compromised vascular health relates to abnormal brain aging and inform strategies to prevent or delay the pathological cascade associated with cognitive impairment and dementia. Furthermore, the proposed award will allow Dr. Jefferson to continue to use her research program as a platform to mentor early career investigators, including undergraduate, graduate, and medical students; postdoctoral fellows; and early career faculty in patient-oriented research in cognitive aging, Alzheimer's disease, and small vessel disease. This proposal integrates Dr. Jefferson's interdisciplinary research team and resources available through the Vanderbilt Memory & Alzheimer's Center and Vanderbilt Institute for Clinical and Translational Research to offer a rich training environment for mentees. The training and research facilitated by this K24 mechanism renewal will not only advance knowledge regarding cardiovascular and cerebrovascular pathways contributing to the pathogenesis and clinical manifestation of Alzheimer's disease and small vessel disease, but it will also develop a cadre of next-generation cognitive aging researchers well- positioned to make meaningful contributions to the field.

本提案要求一次性更新以患者为导向的职业中期研究者奖