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Admin Core

管理核心

基本信息

批准号：
10229540
负责人：
ANGELA L. JEFFERSON
金额：
$ 35.75万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10229540
关键词：
Academic Medical Centers Advisory Committees Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease therapeutic Alzheimer&apos s disease therapy Basic Science Biological Markers Clinical Clinical Research Clinical and Translational Science Awards Collaborations Data Data Storage and Retrieval Development Discipline Disease Pathway Educational workshop Ensure Evaluation Event Faculty Fostering Funding Future Genetic Goals Grant Growth Health Historically Black Colleges and Universities Individual Infrastructure Injury Institutes Investigator-Initiated Research Leadership Link Memory Mission Multi-Institutional Clinical Trial National Institute on Aging Outcome Participant Pathway interactions Pharmacology Policies Positioning Attribute Principal Investigator Protocols documentation Research Research Activity Research Institute Research Personnel Research Training Resource Sharing Resources Science Scientist Site Strategic Planning Structure Techniques Training Activity Translational Research Universities career cohesion cohort cooperative study data exchange data management data sharing early-career faculty graduate student health equity improved medical schools medical specialties meetings neuroimaging next generation novel operation programs ranpirnase repository sharing platform training opportunity undergraduate student vascular contributions

项目摘要

PROJECT SUMMARY – ADMINISTRATIVE CORE The Exploratory Vanderbilt Alzheimer’s Disease Research Center (VADRC) Administrative Core is central to achieving the overall mission of the VADRC and will leverage strong institutional resources to provide excellent administrative oversight for a scalable infrastructure to position Vanderbilt University Medical Center and Vanderbilt University for a future successful P30 application. Under the proven leadership of Dr. Angela Jefferson, supported by Associate Directors, Dr. Consuelo Wilkins and Dr. Charles Sanders, the Administrative Core is uniquely positioned to achieve this goal. Our interdisciplinary Core leadership will ensure that all programmatic objectives of the VADRC are accomplished by coordinating and integrating VADRC Cores and scaling these Center functions into a thriving P30-funded ADRC. Core leadership will drive the Center’s scientific direction emphasizing non-amyloid pathways of injury, including understanding vascular contributions to Alzheimer’s disease and related dementias, discovering novel disease pathways using advanced techniques, and improving pharmacological therapies for Alzheimer’s disease and related dementias. The Administrative Core will serve as the institutional hub for all local Alzheimer’s disease research activities by providing strategic planning, scientific direction, campus-wide integration, and essential infrastructure. Core leadership will identify opportunities for growth while harnessing strengths of existing programs. The Administrative Core will establish and facilitate administrative structure, Center governance, and oversight for Center operations. These functions include managing budgetary oversight, ensuring compliance with regulatory requirements, facilitating ongoing internal and external review and evaluation of VADRC activities, and coordinating fiscal, operational, and regulatory functions to ensure effective utilization of Center resources. The Administrative Core will actively support local research activities and contribute to collaborative national research initiatives and resource sharing to advance the goals of the National Alzheimer’s Project Act. Leadership will establish a scalable data sharing platform to support a future P30 Data Management and Statistical Core. Such infrastructure will promote coordinating and integrating VADRC activities for data transfer that serve local investigator needs and support national research efforts (e.g., National Alzheimer’s Coordinating Center, National Centralized Repository for Alzheimer’s Disease and Related Dementias). Additionally, the Administrative Core will support VADRC participation in multi-site clinical trials. Finally, the Core will be integral in fostering professional development of the next generation of clinicians and scientists in Alzheimer’s disease. Collectively, the VADRC Administrative Core will be instrumental in establishing and facilitating harmonized integration between all Center investigators, collaborators, Core functions, institutional resources, and national partners, which will facilitate a smooth transition to a future P30-funded VADRC.

项目摘要-行政核心探索性范德比尔特阿尔茨海默病研究中心（VADRC）行政核心是核心，实现VADRC的总体使命，并将利用强大的机构资源，对可扩展基础架构的管理监督，以定位范德比尔特大学医学中心，范德比尔特大学为未来成功的P30应用。在安吉拉博士的领导下杰斐逊，由副主任，博士支持Consuelo威尔金斯和博士查尔斯桑德斯，行政核心是唯一的定位，以实现这一目标。我们的跨学科核心领导将确保所有 VADRC的计划目标是通过协调和整合VADRC核心和将这些中心的职能扩展到一个蓬勃发展的P30资助的ADRC。核心领导力将推动中心的强调非淀粉样蛋白损伤途径的科学方向，包括了解血管的贡献阿尔茨海默病和相关痴呆症，发现新的疾病途径，使用先进的技术，并改善阿尔茨海默病和相关痴呆症的药物治疗。的行政核心将作为所有当地阿尔茨海默病研究活动的机构中心，提供战略规划，科学指导，校园范围内的整合和必要的基础设施。核心领导层将在利用现有计划的优势的同时确定增长机会。的行政核心将建立和促进行政结构，中心治理和监督，中心行动。这些职能包括管理预算监督，确保遵守法规要求，促进VADRC活动的持续内部和外部审查和评估，协调财政、运营和监管职能，确保中心资源的有效利用。行政核心将积极支持当地的研究活动，并促进国家合作。研究举措和资源共享，以推进国家阿尔茨海默病项目法案的目标。领导层将建立一个可扩展的数据共享平台，以支持未来的P30数据管理，统计核心。这种基础设施将促进协调和整合VADRC活动，满足当地研究者需求并支持国家研究工作的转让（例如，国家阿尔茨海默氏症协调中心，阿尔茨海默病和相关痴呆症国家集中储存库）。此外，管理核心将支持VADRC参与多中心临床试验。最后核心将是促进下一代临床医生和科学家的专业发展不可或缺的，老年痴呆症总的来说，VADRC行政核心将有助于建立和促进所有中心研究者、合作者、核心职能部门、机构这将有助于顺利过渡到未来由P30供资的VADRC。