Risk factors and prevention targets for abnormal cognitive aging

描述（由申请人提供）：本提案是Angela Jefferson博士的以患者为导向的研究（K24）中期职业研究者奖申请。Jefferson博士是一位临床科学家，其跨学科研究项目的重点是识别轻度认知障碍的早期标志物以及导致阿尔茨海默病（AD）发病机制和临床表现的血流动力学因素。Jefferson博士是范德比尔特大学医学中心的神经病学副教授，也是范德比尔特记忆与阿尔茨海默病中心的创始主任。在完成培训后的8年里，Jefferson博士证明了她对专业教育和指导的承诺，并已成为一名富有成效的以患者为导向的认知老化研究人员，拥有强大的NIH资金和高影响力的出版记录。拟议的奖项将有助于为她提供受保护的时间，以扩大她在认知老化患者为导向的研究能力。特别是，她将获得新的专业知识和创新生物标志物应用的实用技能，以更好地了解加速AD发病机制和临床表现的风险因素。此外，这将使她能够利用她强大的研究计划作为一个平台，指导早期职业调查人员，包括研究生，医学生，博士后研究员和初级教师在认知老化的患者为导向的研究。该提案将PI的跨学科研究团队（包括神经心理学、心脏病学、内分泌学、老年病学、工程学、物理学、神经放射学和生物统计学）与范德比尔特记忆与阿尔茨海默病中心、范德比尔特大学成像科学研究所和范德比尔特临床与医学研究所的相关资源整合在一起。 转化研究为学员提供丰富的培训环境。这种K24机制促进的培训和研究不仅将促进有关AD早期识别标志物和血管风险因素的知识，而且还将培养下一代认知老化研究人员的骨干队伍，为该领域做出有意义的贡献。

DESCRIPTION (provided by applicant): This proposal is a Midcareer Investigator Award in Patient-Oriented Research (K24) application for Angela Jefferson, PhD. Dr. Jefferson is a clinician-scientist whose interdisciplinary research program focuses on identification of early markers for mild cognitive impairment as well as hemodynamic factors contributing to the pathogenesis and clinical manifestation of Alzheimer's disease (AD). Dr. Jefferson is an Associate Professor of Neurology at Vanderbilt University Medical Center and the founding Director of the Vanderbilt Memory & Alzheimer's Center. In the 8 years since completing her training, Dr. Jefferson has demonstrated her commitment to professional education and mentorship and has established herself as a productive patient- oriented researcher in cognitive aging with strong NIH funding and a high-impact publication record. The proposed award will be instrumental in providing her protected time to expand her capabilities in cognitive aging patient-oriented research. In particular, she will gain new expertise and a practical skill set in the application of innovative biomarkers to better understand risk factors for accelerating the pathogenesis and clinical manifestation of AD. Furthermore, it will allow her to use her strong research program as a platform to mentor early career investigators, including graduate students, medical students, post-doctoral fellows, and junior faculty in patient-oriented research in cognitive aging. The proposal integrates the PI's interdisciplinary research team (including neuropsychology, cardiology, endocrinology, geriatrics, engineering, physics, neuroradiology, and biostatistics) with resources associated with the Vanderbilt Memory & Alzheimer's Center, the Vanderbilt University Institute of Imaging Science, and the Vanderbilt Institute for Clinical & Translational Research to offer a rich training environment for mentees. The training and research facilitated by this K24 mechanism will not only advance knowledge regarding early identification markers and vascular risk factors for AD, but it will also develop a cadre of next-generation cognitive aging researchers well-positioned to make meaningful contributions to the field.