UCD Mutant Mouse Regional Resource Center

都柏林大学突变小鼠区域资源中心

• 批准号: 7914687
• 负责人: KC KENT LLOYD
• 金额: $ 39.47万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2011-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7914687
• 关键词: UCD; Mutant; Mouse; Regional; Resource

This is a resubmission of the first competitive continuing application requesting NIH/NCRR support for the next 5 years of the UC Davis Mutant Mouse Regional Resource Center (UCD-MMRRC). The overall objective of the UCD-MMRRC is to serve as a component of the MMRRC National Program, to accept, maintain, and distribute mutant mouse strains for use in biomedical research. The MMRRC program accepts transgenics, knockouts, and all other kinds of mutant mouse lines at no cost to the donor, and after SPF-rederivation and cryopreservation, distributes breeding stock orgermplasm of genetically, and in many cases phenotypically verified mice for a small fee to requesting investigators for non-commercial, academic research purposes only. The UCD-MMRRC currently has a census of >9000 mutant strains maintained as either actively breeding mousecolonies, frozen embryos or germplasm, and/or embryonic stem cell clones. Further, the UCD-MMRRC serves in a coordinated network with 3 other regional MMRRCs as a center of excellence engaged in research and teaching on the biology of the laboratory mouse, providing the scientific community with professional expertise in mutant mouse biology, colony management, conventional and advanced genotyping and phenotyping capabilities, clinical and anatomic pathology services, strain rescue, infectious disease diagnostics and health care, and other areas. In keeping with this mission, this application states 4 interconnected Specific Aims that focus on continuing maintenance of mutant mouse lines in the resource, acceptance of new lines into the resource, research and development projects that eventually will be transferred to the resource to improve its functional efficiency and capabilities, and finally to provide opportunities for outreach and education and training in mouse biology. These Specific Aims are facilitated by closely linked faculty expertise of the UCD Center for Comparative Medicine (CCM), the UCD Mouse Biology Program (UCD-MBP), and the Schools of Medicine and Veterinary Medicine. These relationships allow leveraging of MMRRCsupport, resulting in expanded opportunities for, and benefit to, the MMRRC National Program and the biomedical and behavioral scientific research community.

这是重新提交的第一份竞争性持续申请，请求NIH/NCRR支持 UC Davis Mutant Mouse Regional Resource Center（UCD-MMRRC）整体 UCD-MMRRC的目标是作为MMRRC国家计划的一部分，接受， 维持和分发突变小鼠品系用于生物医学研究。MMRRC计划 接受转基因，敲除和所有其他类型的突变小鼠品系，对捐赠者来说没有任何成本， SPF-再衍生和冷冻保存，分配育种股票或种质的遗传，并在许多 病例表型验证小鼠的一小笔费用，要求研究人员进行非商业性，学术性 仅用于研究目的。UCD-MMRRC目前对>9000株突变株进行了普查， 活跃繁殖的小鼠克隆、冷冻胚胎或种质和/或胚胎干细胞克隆。 此外，UCD-MMRRC在一个协调网络中与其他3个区域MMRRC作为中心， 卓越从事实验室小鼠生物学的研究和教学，提供科学的 社区在突变小鼠生物学、群体管理、常规和 先进的基因分型和表型分析能力，临床和解剖病理学服务，菌株拯救， 传染病诊断和卫生保健等领域。为了完成这一使命， 4个相互关联的具体目标，重点是继续维持突变小鼠品系， 资源，接受新的资源线，研究和开发项目，最终将 转移到资源，以提高其功能效率和能力，并最终提供 小鼠生物学的推广、教育和培训机会。这些具体目标得到促进 通过UCD比较医学中心（CCM）的密切联系的教师专业知识，UCD小鼠 生物学课程（UCD-MBP），以及医学和兽医学院。这些关系 允许利用MMRRC的支持，从而扩大MMRRC的机会并使其受益 国家计划和生物医学和行为科学研究界。