MULTICHANNEL TRANSMIT FRONTEND FOR 7 TESLA

适用于 7 Tesla 的多通道传输前端

• 批准号: 7792104
• 负责人: KAMIL UGURBIL
• 金额: $ 50万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7792104
• 关键词: Biomedical Research; Biotechnology; Brain; Clinical; Development; Dimensions; Discipline; Disease; Freedom; Frequencies; Funding; Head; Health; Human; Human body; Image; Indium; Magnetic Resonance; Magnetic Resonance Imaging; Methodology; Minnesota; Neurosciences; Pattern; Physiologic pulse; Protons; Request for Proposals; Research; Research Personnel; Resources; Signal Transduction; Solutions; System; Techniques; United States National Institutes of Health; Universities; Work; base; instrument; instrumentation; magnetic field; public health relevance; radiofrequency; ranpirnase; tool

DESCRIPTION (provided by applicant): The specific acquisition desired in this application is a eight-channel radiofrequency (RF) transmit front-end capable of generating channel-specific, user- defined RF pulse patterns to drive independent transmit elements in a multichannel transmit or transmit/receive RF array-coil at 7Tesla. The proposed hardware will be incorporated into an existing 7Tesla instrument located within the University of Minnesota's Center for Magnetic Resonance Research (CMRR). This 7 Tesla is the central instrument in the NIH-funded Biotechnology Research Resource Center (P41 RR08079) and the Neuroscience Blueprint Center Core (P30 NS057091) located at the CMRR, and, in this capacity, supports a large number of NIH funded investigators and projects both within and outside of the University of Minnesota. As such, the proposed upgrade will impact a large number of users. This request is based on the fact that imaging in general and magnetic resonance (MR) imaging in particular has evolved to become an indispensible part of contemporary basic and clinical biomedical research, central to discoveries in a large number of disciplines. In this development, recent work has established that ultrahigh magnetic fields (7 Tesla) provide numerous advantages and are emerging at the forefront of this methodology. However, conventional means of exciting MR signals are suboptimal in the brain and simply do not work in the human body at 7 Tesla where the RF wavelength at the proton resonance frequency is ~12 cm and, thus, smaller than the dimensions of the human head or body. In this regime, the radiofrequency (RF) field generated by conventional single, channel transmit systems, is highly non-uniform and power consumptive for most biomedical applications. Solutions to this problem depend on the ability to dynamically control the RF excitation field over a number of degrees of freedom. The proposed instrument is capable of achieving this and is indispensible in the optimal use of the 7 Tesla platforms on human studies. PUBLIC HEALTH RELEVANCE: Magnetic resonance imaging (MRI) is one of the most powerful tools in the armamentarium of techniques employed to investigate the biomedical complexities of the human body in health and disease. This proposal requests funds for instrumentation that will provide a significant enhancement in MRI by enabling the use of higher magnetic fields, which provide significant gains provided that challenges associated with them, can be solved.

描述（由申请人提供）：本申请中所需的特定采集是一个八通道射频（RF）发射前端，能够生成通道特定的用户定义的RF脉冲模式，以在7 T下驱动多通道发射或发射/接收RF阵列线圈中的独立发射元件。拟议的硬件将被纳入现有的7特斯拉仪器位于明尼苏达大学的中心磁共振研究（CMRR）。这7特斯拉是NIH资助的生物技术研究资源中心（P41 RR 08079）和位于CMRR的神经科学蓝图中心核心（P30 NS 057091）的中心仪器，并以这种身份支持大量NIH资助的研究人员和明尼苏达大学内外的项目。因此，拟议的升级将影响大量用户。 这一要求是基于这样一个事实，即一般的成像，特别是磁共振（MR）成像已经发展成为当代基础和临床生物医学研究不可或缺的一部分，在许多学科的发现的核心。在这一发展中，最近的工作已经确定，磁场（7特斯拉）提供了许多优势，并出现在这种方法的最前沿。然而，激励MR信号的常规手段在大脑中是次优的，并且在7特斯拉的人体中根本不起作用，其中质子共振频率下的RF波长为~12 cm，因此小于人类头部或身体的尺寸。在这种情况下，由传统的单通道发射系统产生的射频（RF）场对于大多数生物医学应用来说是高度不均匀的并且是功耗的。这个问题的解决方案取决于在多个自由度上动态控制RF激励场的能力。所提出的仪器能够实现这一点，并且在人体研究中最佳使用7特斯拉平台是不可或缺的。 公共卫生关系：磁共振成像（MRI）是用于研究人体健康和疾病的生物医学复杂性的最强大的工具之一。该提案要求为仪器提供资金，这些仪器将通过使用更高的磁场来显着增强MRI，这将提供显着的收益，前提是可以解决与它们相关的挑战。