GRIN LENS ROD BASED PROBE FOR OFFICE-BASED OCT OF THE HUMAN LARYNX

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 光学相干断层扫描（OCT）是一种不断发展的非侵入性成像模式，它将干涉测量与低相干光相结合，以在混浊介质（如活组织）中产生高分辨率图像，并已用于在外科内窥镜检查期间对喉部进行成像。在办公室环境中清醒患者的喉部的OCT成像受到限制，因为存在若干挑战，包括患者和医生的移动以及喉部在颈部深处的位置。本项目的目的是设计一种新型的OCT采样装置，能够在清醒的办公室硬性喉内窥镜检查期间捕获体内图像。我们提出了一种基于GRIN透镜的探头的新颖设计，该探头能够在典型的基于办公室的喉镜检查期间通过使用谱域OCT来捕获人类喉部的图像。提出了一种既能快速扫描又能动态聚焦且具有恒定光延迟的新型探头。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that combines interferometry with low-coherence light to produce high resolution images in turbid media such as living tissues, and has been used to image the larynx during surgical endoscopy. OCT imaging of the larynx in awake patients in an office setting has been limited because several challenges exist including patient and physician movements and the position of the larynx deep within the neck. The objective of this project is to design a novel OCT sampling device capable of capturing in vivo images during awake office-based rigid laryngeal endoscopy. We propose a novel design of a GRIN lens based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical office based laryngoscopy examination. A novel probe capable of both fast scanning and dynamic focusing with a constant optical delay is presented.