MONTE CARLO METHODS FOR FIBER OPTIC PROBE DESIGN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的主要目标是使用蒙特卡罗模拟来开发新型光纤内窥镜，这种内窥镜可以利用倾斜收集纤维的几何形状同时探测上皮和间质的形态。我们将使用以前报道的人类上皮的散射特性来预测和表征不同探针设计的收集效率和深度分辨率。设计参数将包括源-探测器分离；照明和收集纤维之间的不同角度；纤维直径；收集纤维的数量等。我们将改变上皮的光学属性，以反映癌症的早期发展，并将优化探头设计，以实现对与癌症发生相关的光学变化的最高灵敏度。理论预测将使用定义良好的人体上皮多层光学模体进行验证。该项目的成功完成将导致开发一种简单的仪器，用于通过反射光谱进行非侵入性的、活体实时的癌前检测和监测。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main goal of this project is to use Monte Carlo simulations in development of novel fiber optic endoscopes that can simultaneously probe the epithelial and stromal morphology using oblique collection fiber geometry. We will use previously reported scattering properties of human epithelium to predict and to characterize collection efficiency and depth resolution of different probe designs. Design parameters will include source-detector separation; various angles between illumination and collection fibers; fiber diameter; number of collection fibers, etc. We will change optical properties of the epithelium to reflect early cancer development and will optimize probe design to achieve the highest sensitivity to optical changes that are associated with an onset of carcinogenesis. Theoretical predictions will be tested using well defined multi-layered optical phantoms of human epithelium. Successful completion of the project can lead to development of a simple instrument for non-invasive, real time in vivo pre-cancer detection and monitoring via reflectance spectroscopy.