FDTD MODELING OF LIGHT SCATTERING FROM CELLS AND TISSUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们希望将我们对细胞光散射的时域有限差分(FDTD)建模的各个方面整合到虚拟组织模拟器中。FDTD方法是一种电磁方法，能够在亚微米尺度上精确模拟细胞和其他组织成分的完整光散射特性。虽然FDTD模拟对计算要求很高，但它应该可以为各种蜂窝结构和成分创建一个散射截面和相函数的数据库，并将其整合到宏观蒙特卡罗方法中。这种方法将使用户能够指定组织成分的细胞和亚细胞特征，然后研究微观参数的变化如何转化为宏观光学变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We would like to incorporate aspects of our finite difference time-domain (FDTD) modeling of light scattering from cells into the Virtual Tissue Simulator. The FDTD method is an electromagnetic approach that enables accurate modeling of the complete light scattering properties of cells and other tissue components at the sub-micron scale. Although FDTD simulations are computationally demanding, it should be possible to create a database of scattering cross-sections and phase functions for a wide range of cellular structures and compositions that could be incorporated into macroscopic Monte Carlo methods. Such an approach would enable users to specify cellular and sub-cellular features of tissue components and then investigate how changes in the microscopic parameters translate to macroscopic optical changes.