Mechanisms of Whole Organ Regeneration

全器官再生机制

• 批准号: 8254281
• 负责人: James Wavell Aiken
• 金额: $ 0.75万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8254281
• 关键词: Address; Age; Aging; Aging-Related Process; Animal Model; Animals; Biological; Biology; Bypass; Cells; Colorado; Discipline; Disease; Engineering; Fertilization; Genetic; Goals; Health; Homeostasis; Human; Injury; Invertebrates; Lead; Life; Longevity; Medicine; Modeling; Molecular; Natural regeneration; Nature; Oral; Organ; Organism; Outcome; Physiological; Play; Process; Regenerative Medicine; Request for Proposals; Research; Research Personnel; Role; Scientist; System; Therapeutic; Tissue Engineering; Tissue Transplantation; Tissues; Translational Research; Vertebrates; animal tissue; base; body system; design; insight; meetings; novel; organ regeneration; posters; programs; regenerative; regenerative therapy; repaired; restoration; stem cell biology; stem cell therapy; symposium; tissue culture; tissue regeneration; tool

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Mechanisms of Whole Organ Regeneration, organized by Alejandro Sanchez Alvarado, which will be held in Breckenridge, Colorado from April 1 - 6, 2012. The regeneration of organs and organ systems after injury is widely, but unevenly, distributed among animals. Why organ regeneration is not shared by all animals, and whether mechanisms may or may not be conserved among those animals that can regenerate remain open questions. In recent years, the use of a wider range of model organisms and an increasing ability to use genetic tools to study regeneration has spurred significant progress in our understanding of animal regenerative biology. This meeting aims to delineate the molecular and cell biological basis of regeneration by highlighting, comparing and contrasting the differences and similarities in regenerative capabilities and mechanisms among diverse animal species. How these biological findings may inform regenerative medicine and stem-cell biology and therapeutics will be considered and discussed. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Regenerative Tissue Engineering and Transplantation, which will share an opening and closing keynote address as well as two plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: Regeneration and repair of organs and tissues damaged by injury, age and disease are central goals of regenerative medicine. Yet, many of the biological bases underpinning these processes remain insufficiently understood at best. Identifying viable therapeutic avenues is presently an essential component of regenerative medicine. The objective of the Keystone Symposia meeting on Mechanisms of Whole Organ Regeneration is to bridge the gap between discovery and translational research disciplines that are directly and indirectly studying the problem of regeneration.

描述（由申请人提供）：本提案请求支持将于2012年4月1日至6日在科罗拉多布雷肯里奇举行的由Alejandro Sanchez阿尔瓦拉多组织的题为“全器官再生机制”的Keystone研讨会会议。损伤后器官和器官系统的再生在动物中分布广泛，但不均匀。为什么器官再生不是所有动物都有，以及在那些可以再生的动物中，机制是否可以被保存仍然是悬而未决的问题。近年来，更广泛的模式生物的使用和使用遗传工具研究再生的能力不断提高，促使我们对动物再生生物学的理解取得了重大进展。本次会议旨在通过突出，比较和对比不同动物物种之间再生能力和机制的差异和相似性来描绘再生的分子和细胞生物学基础。这些生物学发现如何为再生医学和干细胞生物学和治疗学提供信息将被考虑和讨论。跨学科互动的机会将大大增强了同期会议再生组织工程和移植，这将分享开幕式和闭幕式主旨演讲，以及两个全体会议与本次会议。 公共卫生相关性：再生和修复因损伤，年龄和疾病而受损的器官和组织是再生医学的中心目标。然而，支撑这些过程的许多生物学基础充其量仍然没有得到充分的理解。确定可行的治疗途径目前是再生医学的重要组成部分。整个器官再生机制的基石研讨会会议的目标是弥合发现和转化研究学科之间的差距，直接和间接地研究再生问题。