Pathogenesis of Influenza: Virus-Host Interactions

流感的发病机制：病毒与宿主的相互作用

• 批准号: 8128073
• 负责人: ANDREW D ROBERTSON
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128073
• 关键词: Address; Adult Respiratory Distress Syndrome; Animal Model; Animal Viruses; Animals; Area; Arts; Asia; Avian Influenza; China; Clinical; Clinical Management; Collaborations; Communicable Diseases; Data; Development; Educational workshop; Experimental Models; Fostering; Hong Kong; Host Defense; Human; Immune response; Immunologist; In Vitro; Influenza; Influenza A Virus, H5N1 Subtype; Intervention; Knowledge; Lead; Link; Lung diseases; Methodology; Natural Immunity; Outcome; Pathogenesis; Patients; Physiological; Play; Prophylactic treatment; Public Health; Request for Proposals; Research; Research Personnel; Risk Assessment; Role; Scientist; Severe Acute Respiratory Syndrome; Systems Biology; Training; Tropism; Vaccines; Viral; Viral Cytopathogenic Effect; Viral Pneumonia; Virulence; Virus; Virus Diseases; Virus Receptors; Work; adaptive immunity; animal data; career; clinical practice; effective intervention; experience; human disease; immunoregulation; improved; influenzavirus; interest; lung injury; meetings; novel; novel therapeutics; pandemic disease; pandemic influenza; posters; respiratory virus; symposium; tissue tropism; transmission process; virus host interaction; virus tropism

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Pathogenesis of Influenza: Virus- Host Interactions, organized by Siamon Gordon, Malik Peiris and Kanta Subbarao, which will be held in Hong Kong, China from May 23 - 28, 2011. The mechanisms underlying the pathogenesis of influenza remain controversial. The direct cytopathic effects of viral replication, tissue tropism of the virus, viral-bacterial synergy, as well as innate host responses are inextricably linked and play roles to varying degrees in "seasonal," zoonotic and pandemic influenza, examples being the pandemics of 1918 and 2009 and H5N1 avian influenza. Animal models, though indispensible, have significant limitations with regard to physiological relevance to human disease. This meeting brings together researchers working on the virus, viral receptors and tissue tropism, innate and adaptive immunity, systems biology and clinical aspects of lung injury and host defense to address questions on the pathogenesis of influenza. The aim will be to integrate data from animal and human experimental models - both ex vivo and in vitro - as well as human disease to understand pathogenesis of influenza and how this may lead to effective interventions. As this symposium will take place in the aftermath of the first pandemic in 40 years, there will be a wealth of new knowledge as well as intense scientific interest in the subject. In view of the particular interest in influenza and other viral respiratory diseases generated in the Asia-Pacific region arising from the avian flu H5N1 and SARS experience, situating the meeting in Hong Kong will be particularly appropriate. PUBLIC HEALTH RELEVANCE: Pandemic influenza remains a major public health issue. There is an urgent need to better understand the origination and development - or pathogenesis - of severe viral infections that cause lung injury, and to explore novel therapeutic options targeting the host. The Keystone Symposia meeting on Pathogenesis of Influenza: Virus-Host Interactions aims to improve our understanding of determinants that facilitate inter- species transmission of influenza viruses.

描述（由申请人提供）：本提案请求支持将于2011年5月23日至28日在中国香港举行的由Siamon Gordon、Malik Peiris和Kanta Subbarao组织的题为“流感发病机制：病毒-宿主相互作用”的Keystone研讨会会议。流感的发病机制仍然存在争议。病毒复制的直接致细胞病变效应、病毒的组织嗜性、病毒-细菌协同作用以及先天宿主反应是密不可分的，并且在“季节性”、人畜共患和大流行性流感中不同程度地发挥作用，例如1918年和2009年的大流行以及H5 N1禽流感。动物模型虽然不可或缺，但在与人类疾病的生理相关性方面具有显著的局限性。本次会议汇集了研究人员的病毒，病毒受体和组织嗜性，先天性和适应性免疫，系统生物学和肺损伤和宿主防御的临床方面，以解决有关流感的发病机制的问题。其目的是整合来自动物和人类实验模型（包括体外和体外）以及人类疾病的数据，以了解流感的发病机制以及如何采取有效的干预措施。由于本次研讨会将在40年来第一次大流行之后举行，因此将有大量的新知识以及对该主题的强烈科学兴趣。鉴于H5 N1禽流感和严重急性呼吸系统综合症在亚太区引起的流感和其他病毒性呼吸系统疾病引起特别关注，会议在香港举行将特别合适。 公共卫生相关性：大流行性流感仍然是一个重大的公共卫生问题。迫切需要更好地了解导致肺损伤的严重病毒感染的起源和发展-或发病机制-并探索针对宿主的新治疗方案。关于流感发病机制的基石研讨会：病毒-宿主相互作用旨在提高我们对促进流感病毒种间传播的决定因素的理解。