Pathogenesis of Influenza: Virus-Host Interactions

描述(由申请人提供)：本提案请求支持将于2011年5月23-28日在香港举行的题为流感的发病机制：病毒-宿主相互作用的Keystone研讨会，该会议由Siamon Gordon，Malik Peiris和Kanta Subarao组织，中国。流感的发病机制仍然存在争议。病毒复制的直接细胞病变效应、病毒的组织嗜性、病毒与细菌的协同作用以及固有的宿主反应是密不可分的，并在不同程度上在“季节性”、人畜共患病和大流行性流感中发挥作用，例如1918年和2009年的大流行以及H5N1禽流感。动物模型虽然是必不可少的，但在与人类疾病的生理相关性方面有很大的局限性。这次会议汇集了研究病毒、病毒受体和组织嗜性、先天和获得性免疫、系统生物学和肺损伤的临床方面以及宿主防御的研究人员，以解决流感的发病机制问题。其目的将是整合来自动物和人类实验模型--包括体外和体外--以及人类疾病的数据，以了解流感的发病机制以及这可能如何导致有效的干预措施。由于这次研讨会将在40年来的第一次大流行之后举行，将会有丰富的新知识以及对这一主题的强烈科学兴趣。鉴于禽流感H5N1和严重急性呼吸系统综合症在亚太地区引发的流感和其他病毒性呼吸系统疾病特别受到关注，将会议地点设在香港将是特别合适的。 公共卫生相关性：大流行性流感仍然是一个重大的公共卫生问题。迫切需要更好地了解导致肺损伤的严重病毒感染的起源和发展--或发病机制，并探索针对宿主的新的治疗方案。关于流感的发病机制：病毒与宿主之间的相互作用的重要研讨会旨在提高我们对促进流感病毒跨物种传播的决定因素的了解。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Pathogenesis of Influenza: Virus- Host Interactions, organized by Siamon Gordon, Malik Peiris and Kanta Subbarao, which will be held in Hong Kong, China from May 23 - 28, 2011. The mechanisms underlying the pathogenesis of influenza remain controversial. The direct cytopathic effects of viral replication, tissue tropism of the virus, viral-bacterial synergy, as well as innate host responses are inextricably linked and play roles to varying degrees in "seasonal," zoonotic and pandemic influenza, examples being the pandemics of 1918 and 2009 and H5N1 avian influenza. Animal models, though indispensible, have significant limitations with regard to physiological relevance to human disease. This meeting brings together researchers working on the virus, viral receptors and tissue tropism, innate and adaptive immunity, systems biology and clinical aspects of lung injury and host defense to address questions on the pathogenesis of influenza. The aim will be to integrate data from animal and human experimental models - both ex vivo and in vitro - as well as human disease to understand pathogenesis of influenza and how this may lead to effective interventions. As this symposium will take place in the aftermath of the first pandemic in 40 years, there will be a wealth of new knowledge as well as intense scientific interest in the subject. In view of the particular interest in influenza and other viral respiratory diseases generated in the Asia-Pacific region arising from the avian flu H5N1 and SARS experience, situating the meeting in Hong Kong will be particularly appropriate. PUBLIC HEALTH RELEVANCE: Pandemic influenza remains a major public health issue. There is an urgent need to better understand the origination and development - or pathogenesis - of severe viral infections that cause lung injury, and to explore novel therapeutic options targeting the host. The Keystone Symposia meeting on Pathogenesis of Influenza: Virus-Host Interactions aims to improve our understanding of determinants that facilitate inter- species transmission of influenza viruses.