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Environmental Epigenomics and Disease Susceptibility

环境表观基因组学和疾病易感性

基本信息

批准号：
8130161
负责人：
ANDREW D ROBERTSON
金额：
$ 1.22万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-27 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8130161
关键词：
Adult Animals Area Asthma Autistic Disorder Awareness Behavior Biological Process Biology Bipolar Disorder Brain Cardiovascular Diseases Child Clinical Clinical Investigator Clinical Research Collaborations Communities Complex Data Development Developmental Biology Diabetes Mellitus Disease Disease Outcome Disease susceptibility Endocrine Disruptors Environment Environmental Exposure Environmental Risk Factor Epidemiology Epigenetic Process Ethics Exposure to Gene Expression Generations Genes Genome Goals Health Human Infant Knowledge Lead Legal Life Malignant Neoplasms Maps Medical Methodology Modification Mutate Neurosciences North Carolina Obesity Outcome Pathogenesis Pathway interactions Pharmaceutical Preparations Play Process Public Health Regulation Request for Proposals Research Research Personnel Resources Risk Role Schizophrenia Science Scientist Small RNA Stress Toxicology Training United States National Institutes of Health Work clinical practice dietary supplements environmental agent environmental chemical epigenomics gene environment interaction high throughput technology human disease imprint interest meetings nervous system disorder novel diagnostics nutrition postnatal prenatal programs response stressor symposium

项目摘要

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Environmental Epigenomics and Disease Susceptibility, organized by Randy L. Jirtle, Moshe Szyf and Frederick L. Tyson, which will be held in Asheville, North Carolina from March 27 - April 1, 2011. There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders is influenced by persistent epigenetic adaptations in response to prenatal and early postnatal environmental exposures. Thus, to effectively promote public health, it is critical to determine whether environmental factors as diverse as endocrine disruptors, nutritional supplements, and nurturing behavior can alter the pathogenesis of adult diseases by modifying the epigenome rather than mutating the genome. These are the scientific topics that will be discussed in depth at the Keystone Symposia meeting on Environmental Epigenomics and Disease Susceptibility. More specifically, the objective of this meeting is to provide evidence that environmental exposures during early development, by modifying the epigenome, can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life. In particular, the importance of environmentally-induced epigenetic effects on brain development will be stressed in this meeting. PUBLIC HEALTH RELEVANCE: The complex biological processes underlying states of health and disease involve gene-environment interactions (or epigenetics) between many genes and external influences such as environmental chemicals, stressors, nutrition, and drugs. In fact, environmental agents have been associated with a number of diseases including autism, bipolar disorder, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia. The Keystone Symposia meeting on Environmental Epigenomics and Disease Susceptibility will examine the evidence that environmental exposures during early development, by modifying the epigenome, can alter the risk of developing medical conditions later in life.

描述（由申请人提供）：本提案请求支持由 Randy L. Jirtle、Moshe Szyf 和 Frederick L. Tyson 组织的题为“环境表观基因组学和疾病易感性”的 Keystone 研讨会，该会议将于 2011 年 3 月 27 日至 4 月 1 日在北卡罗来纳州阿什维尔举行。现在有令人信服的人类流行病学和动物实验数据表明发生成人发病综合症的风险疾病和神经系统疾病受到针对产前和产后早期环境暴露的持续表观遗传适应的影响。因此，为了有效促进公共卫生，至关重要的是确定内分泌干扰物、营养补充剂和养育行为等多种环境因素是否可以通过改变表观基因组而不是突变基因组来改变成人疾病的发病机制。这些都是将在环境表观基因组学和疾病易感性 Keystone 研讨会上深入讨论的科学主题。更具体地说，本次会议的目的是提供证据，证明早期发育过程中的环境暴露可以通过改变表观基因组来改变以后患哮喘、自闭症、癌症、心血管疾病、糖尿病、肥胖和精神分裂症等疾病的风险。本次会议将特别强调环境引起的表观遗传效应对大脑发育的重要性。公共卫生相关性：健康和疾病状态背后的复杂生物过程涉及许多基因之间的基因-环境相互作用（或表观遗传学）以及环境化学物质、压力源、营养和药物等外部影响。事实上，环境因素与许多疾病有关，包括自闭症、躁郁症、癌症、心血管疾病、糖尿病、肥胖症和精神分裂症。关于环境表观基因组学和疾病易感性的 Keystone 研讨会将审查早期发育过程中的环境暴露通过修改表观基因组可以改变晚年罹患疾病的风险的证据。