Environmental Epigenomics and Disease Susceptibility
环境表观基因组学和疾病易感性
基本信息
- 批准号:8130161
- 负责人:
- 金额:$ 1.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-03-27 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAnimalsAreaAsthmaAutistic DisorderAwarenessBehaviorBiological ProcessBiologyBipolar DisorderBrainCardiovascular DiseasesChildClinicalClinical InvestigatorClinical ResearchCollaborationsCommunitiesComplexDataDevelopmentDevelopmental BiologyDiabetes MellitusDiseaseDisease OutcomeDisease susceptibilityEndocrine DisruptorsEnvironmentEnvironmental ExposureEnvironmental Risk FactorEpidemiologyEpigenetic ProcessEthicsExposure toGene ExpressionGenerationsGenesGenomeGoalsHealthHumanInfantKnowledgeLeadLegalLifeMalignant NeoplasmsMapsMedicalMethodologyModificationMutateNeurosciencesNorth CarolinaObesityOutcomePathogenesisPathway interactionsPharmaceutical PreparationsPlayProcessPublic HealthRegulationRequest for ProposalsResearchResearch PersonnelResourcesRiskRoleSchizophreniaScienceScientistSmall RNAStressToxicologyTrainingUnited States National Institutes of HealthWorkclinical practicedietary supplementsenvironmental agentenvironmental chemicalepigenomicsgene environment interactionhigh throughput technologyhuman diseaseimprintinterestmeetingsnervous system disordernovel diagnosticsnutritionpostnatalprenatalprogramsresponsestressorsymposium
项目摘要
DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Environmental Epigenomics and Disease Susceptibility, organized by Randy L. Jirtle, Moshe Szyf and Frederick L. Tyson, which will be held in Asheville, North Carolina from March 27 - April 1, 2011. There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders is influenced by persistent epigenetic adaptations in response to prenatal and early postnatal environmental exposures. Thus, to effectively promote public health, it is critical to determine whether environmental factors as diverse as endocrine disruptors, nutritional supplements, and nurturing behavior can alter the pathogenesis of adult diseases by modifying the epigenome rather than mutating the genome. These are the scientific topics that will be discussed in depth at the Keystone Symposia meeting on Environmental Epigenomics and Disease Susceptibility. More specifically, the objective of this meeting is to provide evidence that environmental exposures during early development, by modifying the epigenome, can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life. In particular, the importance of environmentally-induced epigenetic effects on brain development will be stressed in this meeting.
PUBLIC HEALTH RELEVANCE: The complex biological processes underlying states of health and disease involve gene-environment interactions (or epigenetics) between many genes and external influences such as environmental chemicals, stressors, nutrition, and drugs. In fact, environmental agents have been associated with a number of diseases including autism, bipolar disorder, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia. The Keystone Symposia meeting on Environmental Epigenomics and Disease Susceptibility will examine the evidence that environmental exposures during early development, by modifying the epigenome, can alter the risk of developing medical conditions later in life.
描述(由申请人提供):本提案要求支持由Randy L. Jirtle, Moshe Szyf和Frederick L. Tyson组织的题为“环境表观基因组学和疾病易感性”的Keystone专题会议,该会议将于2011年3月27日至4月1日在北卡罗来纳州阿什维尔举行。现在有令人信服的人类流行病学和动物实验数据表明,发生成人发病的复杂疾病和神经障碍的风险受到产前和产后早期环境暴露的持续表观遗传适应的影响。因此,为了有效地促进公众健康,至关重要的是要确定各种环境因素,如内分泌干扰物、营养补充剂和养育行为,是否可以通过修改表观基因组而不是突变基因组来改变成人疾病的发病机制。这些都是将在Keystone环境表观基因组学和疾病易感性专题会议上深入讨论的科学主题。更具体地说,这次会议的目的是提供证据,证明早期发育期间的环境暴露,通过改变表观基因组,可以改变以后生活中发生哮喘、自闭症、癌症、心血管疾病、糖尿病、肥胖和精神分裂症等疾病的风险。这次会议将特别强调环境诱导的表观遗传效应对大脑发育的重要性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ANDREW D ROBERTSON其他文献
ANDREW D ROBERTSON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ANDREW D ROBERTSON', 18)}}的其他基金
Mechanisms of Cardiac Growth, Death and Regeneration
心脏生长、死亡和再生的机制
- 批准号:
8056942 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics
分枝杆菌:生理学、代谢和发病机制 - 回到基础
- 批准号:
8055811 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
Immunity in the Respiratory Tract: Challenges of the Lung Environment
呼吸道免疫:肺部环境的挑战
- 批准号:
8057229 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
Pathogenesis of Influenza: Virus-Host Interactions
流感的发病机制:病毒与宿主的相互作用
- 批准号:
8128073 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
Drugs from Bugs: The Anti-Inflammatory Drugs of Tomorrow
昆虫药物:明天的抗炎药物
- 批准号:
8124051 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies
结核病:免疫学、细胞生物学和新型疫苗接种策略
- 批准号:
8055809 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses
NK 和 NKT 细胞生物学:先天反应的特异性和冗余
- 批准号:
8006107 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
MicroRNAs and Human Disease - Olson, Chair
MicroRNA 与人类疾病 - Olson,主席
- 批准号:
8061929 - 财政年份:2011
- 资助金额:
$ 1.22万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 1.22万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 1.22万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 1.22万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 1.22万 - 项目类别:
Discovery Early Career Researcher Award
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 1.22万 - 项目类别:
Continuing Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 1.22万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Analysis of thermoregulatory mechanisms by the CNS using model animals of female-dominant infectious hypothermia
使用雌性传染性低体温模型动物分析中枢神经系统的体温调节机制
- 批准号:
23KK0126 - 财政年份:2023
- 资助金额:
$ 1.22万 - 项目类别:
Fund for the Promotion of Joint International Research (International Collaborative Research)
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 1.22万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 1.22万 - 项目类别:
Training Grant














{{item.name}}会员




