Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics

分枝杆菌：生理学、代谢和发病机制 - 回到基础

• 批准号: 8055811
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8055811
• 关键词: Address; Area; Attention; Back; Biological Models; Biology; British Columbia; Canada; Cellular biology; Clinical Trials; Collaborations; Data; Discipline; Disease; Educational workshop; Exposure to; Generations; Genetic Variation; Genus Mycobacterium; Goals; Immunology; Investigation; Joints; Knowledge; Lead; Metabolism; Mycobacterium tuberculosis; Outcome; Participant; Pathogenesis; Pharmaceutical Preparations; Physiology; Prevention; Request for Proposals; Research; Research Personnel; Resources; Running; Scientist; Students; Systems Biology; Training; Tuberculosis; Vaccines; Work; biological adaptation to stress; design; flexibility; global health; innovation; interest; killings; meetings; methionylmethionine; neglect; new technology; novel; novel diagnostics; pathogen; programs; symposium; tuberculosis treatment; vaccination strategy

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Mycobacteria: Physiology, Metabolism and Pathogenesis- Back to the Basics, organized by David R. Sherman and Sabine Ehrt, which will be held in Vancouver, British Columbia, Canada from January 15 - 20, 2011. This meeting will address basic understanding, treatment, and prevention of tuberculosis, with a focus on the physiology, metabolism, and pathogenesis of M. tuberculosis. While the Mycobacteria program is primarily pathogen-focused, we have planned this meeting to run in parallel with the Keystone Symposia meeting on Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies, a program focused on the host. In combination, these meetings are designed to attract scientists with interests in both pathogen- and host-focused disciplines, while providing joint sessions each day to encourage and facilitate interactions. For example, we will host a joint session on "Systems Biology", an innovative and powerful approach that is just starting to be applied to TB research. Joint sessions will also address treatment and prevention of tuberculosis with sessions on drug and vaccine discovery strategies, and capacity-building for clinical trials. Other joint sessions include a focus on the host- pathogen interface. The pairing of the Mycobacteria meeting and the meeting on Tuberculosis- which will share a keynote address, 4 plenary sessions, and 2 workshops- renders this meeting unique and enhances opportunities for exchanges between researchers who do not typically interact. The Mycobacteria meeting is intended to provide a state-of-the-art overview of M. tuberculosis biology and pathogenesis; to highlight the translational implications of this work; to provide researchers with access to relevant data from diverse model systems, topics and levels of investigation; and to help define the most important questions to be addressed. Project Narrative: Tuberculosis (TB) is a devastating global health crisis, killing someone in the world every 15 seconds. After decades of neglect, TB research has gained increasing attention and resources in recent years. This resurgence has resulted in many significant findings on the biology of TB disease, including discoveries that may lead to new diagnostics, drugs and vaccines. The Keystone Symposia meeting on Mycobacteria: Physiology, Metabolism and Pathogenesis- Back to the Basics will address the latest findings on the physiology, metabolism, and pathogenesis of TB.

描述（由申请人提供）： 该提案请求支持由 David R. Sherman 和 Sabine Ehrt 组织的题为“分枝杆菌：生理学、代谢和发病机制 - 回到基础”的 Keystone 研讨会，该会议将于 2011 年 1 月 15 日至 20 日在加拿大不列颠哥伦比亚省温哥华举行。该会议将讨论结核病的基本理解、治疗和预防，重点关注生理学、代谢、 和结核分枝杆菌的发病机制。虽然分枝杆菌计划主要以病原体为重点，但我们计划本次会议与结核病 Keystone 研讨会同期举行：免疫学、细胞生物学和新型疫苗接种策略，这是一个以东道主为重点的计划。这些会议旨在吸引对病原体和宿主学科感兴趣的科学家，同时每天举行联合会议以鼓励和促进互动。例如，我们将举办一场关于“系统生物学”的联合会议，这是一种创新而强大的方法，刚刚开始应用于结核病研究。联合会议还将讨论结核病的治疗和预防问题，以及药物和疫苗发现策略以及临床试验能力建设的会议。其他联合会议包括对宿主-病原体界面的关注。分枝杆菌会议和结核病会议的配对（将分享一次主题演讲、4 场全体会议和 2 场研讨会）使本次会议变得独特，并增加了通常不互动的研究人员之间的交流机会。分枝杆菌会议旨在提供结核分枝杆菌生物学和发病机制的最新概述；强调这项工作的翻译意义；为研究人员提供来自不同模型系统、主题和调查级别的相关数据；并帮助定义需要解决的最重要的问题。 项目叙述： 结核病 (TB) 是一场毁灭性的全球健康危机，世界上每 15 秒就有一人死亡。经过几十年的忽视，结核病研究近年来获得了越来越多的关注和资源。这种复苏导致了结核病生物学的许多重要发现，包括可能导致新的诊断方法、药物和疫苗的发现。分枝杆菌：生理学、代谢和发病机制 - 回到基础的 Keystone 研讨会将讨论结核病生理学、代谢和发病机制的最新发现。