MicroRNAs and Human Disease - Olson, Chair

MicroRNA 与人类疾病 - Olson，主席

• 批准号: 8061929
• 负责人: ANDREW D ROBERTSON
• 金额: $ 2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-14 至 2011-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061929
• 关键词: Academia; Alberta province; Biology; Blood Vessels; Canada; Cardiovascular Diseases; Central Nervous System Diseases; Chemistry; Clinical; Collaborations; Communicable Diseases; Development; Diagnostic; Discipline; Disease; Educational workshop; Functional RNA; Gene Expression; Genes; Goals; Heart Diseases; Human Biology; Industry; Joints; Learning; Malignant Neoplasms; Methods; MicroRNAs; Myopathy; Oligonucleotides; Outcome; RNA; Regulation; Reporting; Request for Proposals; Research; Research Personnel; Research Subjects; Role; Scientist; Stem cells; Students; Therapeutic; Time; Virus Diseases; Work; base; experience; human disease; in vivo; insight; interest; meetings; nervous system disorder; novel; symposium; therapeutic target; tool

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Microns and Human Disease, organized by Eric N. Olson, Safari Kauppinen and Eva van Rooij, which will be held in Banff, Alberta, Canada from February 11 - 16, 2011. MicroRNAs have emerged as key regulators of numerous diseases including cancer, heart disease, neurological disorders and vascular abnormalities. The Keystone Symposia meeting on MicroRNAs and Human Disease will focus on new discoveries surrounding the function and therapeutic opportunities of miRNAs in human disease. This meeting will bring together a broad range of scientific and clinical experts in a number of diseases. Because the meeting will be held concurrently with the Keystone Symposia meeting on MicroRNAs and Non-Coding RNAs and Cancer, this meeting will focus on diseases other than cancer, such as cardiovascular, muscle, infectious, and neurological diseases. Joint plenary sessions will focus on microRNA mechanisms of action and the identification of microRNA targets, as well as the latest advances on the roles of microRNAs in stem cells. The meetings will conclude with a combined session on recent advances in microRNA therapeutics. PUBLIC HEALTH RELEVANCE: In the last few years it has become increasingly clear that microRNAs (miRNAs) - small segments of RNA that each regulate hundreds of genes - fulfill important roles in a variety of disease states like cancer, central nervous system disorders, viral, muscle and cardiovascular disease. Due to the apparent roles of miRNAs in multiple disease states, there has been a tremendous increase in interest in miRNA function and the feasibility of using these disease regulators as therapeutic targets and diagnostic tools. Based on rapid developments in this field, this Keystone Symposia meeting on MicroRNAs and Human Disease will provide insight and clarity regarding recent discoveries as well as facilitate interactions among scientific leaders, students and trainees working in this field.

描述（由申请人提供）：本提案请求支持由 Eric N. Olson、Safari Kauppinen 和 Eva van Rooij 组织的题为“微米与人类疾病”的 Keystone 研讨会，该会议将于 2011 年 2 月 11 日至 16 日在加拿大艾伯塔省班夫举行。MicroRNA 已成为多种疾病的关键调节因子，包括癌症、心脏病、神经系统疾病和血管疾病 异常。关于 MicroRNA 和人类疾病的 Keystone 研讨会将重点关注有关 miRNA 在人类疾病中的功能和治疗机会的新发现。这次会议将汇集多种疾病领域的广泛科学和临床专家。由于本次会议将与MicroRNAs和Non-Coding RNAs与癌症Keystone Symposia会议同期举行，因此本次会议将重点关注癌症以外的疾病，如心血管、肌肉、传染病和神经系统疾病。联合全体会议将重点讨论microRNA的作用机制和microRNA靶标的识别，以及microRNA在干细胞中作用的最新进展。会议将以关于 microRNA 疗法最新进展的联合会议结束。 公共健康相关性：在过去几年中，人们越来越清楚地认识到，microRNA (miRNA)——RNA 的小片段，每个片段调节数百个基因——在癌症、中枢神经系统疾病、病毒、肌肉和心血管疾病等多种疾病状态中发挥着重要作用。由于 miRNA 在多种疾病状态中的明显作用，人们对 miRNA 功能以及使用这些疾病调节因子作为治疗靶点和诊断工具的可行性的兴趣大大增加。基于该领域的快速发展，本次关于 MicroRNA 和人类疾病的 Keystone 研讨会将提供有关最新发现的见解和清晰度，并促进该领域工作的科学领导者、学生和受训人员之间的互动。