MicroRNAs and Human Disease - Olson, Chair

MicroRNA 与人类疾病 - Olson，主席

• 批准号: 8061929
• 负责人: ANDREW D ROBERTSON
• 金额: $ 2万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-14 至 2011-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061929
• 关键词: Academia; Alberta province; Biology; Blood Vessels; Canada; Cardiovascular Diseases; Central Nervous System Diseases; Chemistry; Clinical; Collaborations; Communicable Diseases; Development; Diagnostic; Discipline; Disease; Educational workshop; Functional RNA; Gene Expression; Genes; Goals; Heart Diseases; Human Biology; Industry; Joints; Learning; Malignant Neoplasms; Methods; MicroRNAs; Myopathy; Oligonucleotides; Outcome; RNA; Regulation; Reporting; Request for Proposals; Research; Research Personnel; Research Subjects; Role; Scientist; Stem cells; Students; Therapeutic; Time; Virus Diseases; Work; base; experience; human disease; in vivo; insight; interest; meetings; nervous system disorder; novel; symposium; therapeutic target; tool

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Microns and Human Disease, organized by Eric N. Olson, Safari Kauppinen and Eva van Rooij, which will be held in Banff, Alberta, Canada from February 11 - 16, 2011. MicroRNAs have emerged as key regulators of numerous diseases including cancer, heart disease, neurological disorders and vascular abnormalities. The Keystone Symposia meeting on MicroRNAs and Human Disease will focus on new discoveries surrounding the function and therapeutic opportunities of miRNAs in human disease. This meeting will bring together a broad range of scientific and clinical experts in a number of diseases. Because the meeting will be held concurrently with the Keystone Symposia meeting on MicroRNAs and Non-Coding RNAs and Cancer, this meeting will focus on diseases other than cancer, such as cardiovascular, muscle, infectious, and neurological diseases. Joint plenary sessions will focus on microRNA mechanisms of action and the identification of microRNA targets, as well as the latest advances on the roles of microRNAs in stem cells. The meetings will conclude with a combined session on recent advances in microRNA therapeutics. PUBLIC HEALTH RELEVANCE: In the last few years it has become increasingly clear that microRNAs (miRNAs) - small segments of RNA that each regulate hundreds of genes - fulfill important roles in a variety of disease states like cancer, central nervous system disorders, viral, muscle and cardiovascular disease. Due to the apparent roles of miRNAs in multiple disease states, there has been a tremendous increase in interest in miRNA function and the feasibility of using these disease regulators as therapeutic targets and diagnostic tools. Based on rapid developments in this field, this Keystone Symposia meeting on MicroRNAs and Human Disease will provide insight and clarity regarding recent discoveries as well as facilitate interactions among scientific leaders, students and trainees working in this field.

描述（由申请人提供）：该提案请求支持Keystone研讨会会议，标题为“ Microns and Human Deasany”，由Eric N. Olson，Safari Kauppinen和Eva Van Rooij组织，该组织将于2011年2月11日至16日在加拿大艾伯塔省艾伯塔省举行。异常。 Keystone研讨会会议上有关microRNA和人类疾病的会议将集中于有关人类疾病中miRNA功能和治疗机会的新发现。这次会议将汇集多种疾病的大量科学和临床专家。由于会议将同时举行有关MicroRNA和非编码RNA和癌症的Keystone研讨会会议，因此这次会议将集中于癌症以外的其他疾病，例如心血管，肌肉，肌肉，传染病和神经系统疾病。联合全体会议将集中于microRNA作用机理和鉴定microRNA靶标，以及关于microRNA在干细胞中作用的最新进展。会议将在MicroRNA治疗剂的最新进展中结束。 公共卫生相关性：在过去的几年中，越来越明显的是，microRNA（miRNA） - 每个调节数百个基因的RNA的一小部分 - 在癌症，中枢神经系统疾病，病毒，肌肉和心血管疾病等多种疾病状态中扮演重要角色。由于miRNA在多种疾病状态中的明显作用，因此对miRNA功能的兴趣有很大增加，以及使用这些疾病调节剂作为治疗靶标和诊断工具的可行性。基于该领域的快速发展，这次有关MicroRNA和人类疾病的Keystone研讨会会议将为最新发现以及促进在该领域工作的科学领袖，学生和学员之间的互动提供见解和清晰度。