NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses

NK 和 NKT 细胞生物学：先天反应的特异性和冗余

• 批准号: 8006107
• 负责人: ANDREW D ROBERTSON
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006107
• 关键词: Address; Autoimmunity; Biological; Cell Shape; Cells; Cellular biology; Clinic; Collaborations; Colorado; Development; Disease; Immune; Immune response; Infection; Inflammatory; International; Lead; Learning; Ligands; Lymphocyte; Lymphocyte Subset; Malignant Neoplasms; Mediator of activation protein; Natural Immunity; Natural Killer Cells; Organ; Population; Process; Regulation; Request for Proposals; Role; Scanning; Signal Transduction; Specificity; Text; abstracting; cell type; knowledge base; meetings; pathogen; response; symposium

DESCRIPTION (provided by applicant): Abstract PI: ROBERTSON, ANDREW D Project: 1R13AI091292-01 Title: NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses Accession Number: 3255538 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== This proposal requests support for a Keystone Symposia meeting entitled NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses, organized by James P. Di Santo, Eleanor M. Riley and Mitchell Kronenberg, which will be held in Breckenridge, Colorado from January 9 - 14, 2011. Our knowledge base in innate immunity has exploded over the past decade, and our understanding of innate immune mechanisms will soon impact in the clinics. Nevertheless, we still have much to learn about how NK cells and NKT cells shape innate and adaptive immune responses. This meeting will address issues related to the biological roles of these two specialized innate lymphocyte populations by bringing together NK and NKT cell experts to discuss their latest cutting-edge results on topics including NK/NKT development; NK/NKT cell- ligand recognition; NK/NKT activation and "crosstalk"; and roles for NK/NKT cells as both effectors and regulators of the immune response in inflammatory disease, infection and cancer. This "confrontation" between NK cell and NKT cell biologists should promote a lively forum for discussion and debate about the specificity and redundancy of NK/NKT cell responses, and can hopefully lead to new collaborations to help advance our understanding of the biological roles of these important innate mediators. In fact, this meeting is the only international meeting that brings together the world's leading experts on NK and NKT cell biology in a forum that is uniquely devoted to understanding the "crosstalk" between these two innate lymphocyte subsets. This meeting will address many questions related to fundamental mechanisms involved in the activation and regulation of immune responses to infectious pathogens. Moreover, understanding NK and NKT cell biology has broad implications, and therefore multiple, diverse plenary sessions will be devoted to the study of these two cell types, encompassing everything from signaling and development to whole organ studies of immune responses in the context of infection, autoimmunity and cancer.

描述（由申请人提供）： 抽象的 PI：Robertson，Andrew D项目：1R13AI091292-01标题：NK和NKT细胞生物学：先天响应的特殊性和冗余登录编号：3255538 =================== 注意：此摘要是从应用程序中提取的，尚未由SRA证明。当应用程序扫描过程存在问题时，提取的文本可能不正确或不完整。 =================== 该提议要求支持Keystone研讨会会议，标题为NK和NKT细胞生物学：先天性反应的特异性和冗余，由James P. Di Santo，Eleanor M. Riley和Mitchell Kronenberg组织，将在2011年1月9日至14日至14年的Inselation Insperione Insperione and Inspriese cressione cressione cressiondiess cressiondiess cressiondiess cressiondiess cressiondiess中，我们的知识基础。机制将很快影响诊所。然而，我们仍然有很多了解NK细胞和NKT细胞如何塑造先天和适应性免疫反应。这次会议将通过将NK和NKT细胞专家召集在一起，讨论其有关NK/NKT开发等主题的最新尖端结果，讨论与这两个专业先天淋巴细胞种群的生物学作用有关的问题； NK/NKT细胞识别； NK/NKT激活和“串扰”； NK/NKT细胞作为炎症性疾病，感染和癌症中免疫反应的效应子和调节剂的作用。 NK细胞与NKT细胞生物学家之间的这种“对抗”应促进一个生动的论坛，讨论和辩论NK/NKT细胞反应的特异性和冗余，并希望有望导致新的合作，以帮助我们促进我们对这些重要固有介体的生物学作用的理解。实际上，这次会议是唯一一场国际会议，在一个论坛中汇集了全球领先的NK和NKT细胞生物学专家，该论坛专门致力于理解这两个先天淋巴细胞群之间的“串扰”。这次会议将解决与有关传染病的免疫反应激活和调节有关的基本机制有关的许多问题。此外，了解NK和NKT细胞生物学具有广泛的含义，因此，多种多样的全体会议将致力于研究这两种细胞类型，包括在感染，自身免疫性和癌症的背景下，从信号传导和开发到整个免疫反应的所有物体研究。