NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses

NK 和 NKT 细胞生物学：先天反应的特异性和冗余

• 批准号: 8006107
• 负责人: ANDREW D ROBERTSON
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006107
• 关键词: Address; Autoimmunity; Biological; Cell Shape; Cells; Cellular biology; Clinic; Collaborations; Colorado; Development; Disease; Immune; Immune response; Infection; Inflammatory; International; Lead; Learning; Ligands; Lymphocyte; Lymphocyte Subset; Malignant Neoplasms; Mediator of activation protein; Natural Immunity; Natural Killer Cells; Organ; Population; Process; Regulation; Request for Proposals; Role; Scanning; Signal Transduction; Specificity; Text; abstracting; cell type; knowledge base; meetings; pathogen; response; symposium

DESCRIPTION (provided by applicant): Abstract PI: ROBERTSON, ANDREW D Project: 1R13AI091292-01 Title: NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses Accession Number: 3255538 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== This proposal requests support for a Keystone Symposia meeting entitled NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses, organized by James P. Di Santo, Eleanor M. Riley and Mitchell Kronenberg, which will be held in Breckenridge, Colorado from January 9 - 14, 2011. Our knowledge base in innate immunity has exploded over the past decade, and our understanding of innate immune mechanisms will soon impact in the clinics. Nevertheless, we still have much to learn about how NK cells and NKT cells shape innate and adaptive immune responses. This meeting will address issues related to the biological roles of these two specialized innate lymphocyte populations by bringing together NK and NKT cell experts to discuss their latest cutting-edge results on topics including NK/NKT development; NK/NKT cell- ligand recognition; NK/NKT activation and "crosstalk"; and roles for NK/NKT cells as both effectors and regulators of the immune response in inflammatory disease, infection and cancer. This "confrontation" between NK cell and NKT cell biologists should promote a lively forum for discussion and debate about the specificity and redundancy of NK/NKT cell responses, and can hopefully lead to new collaborations to help advance our understanding of the biological roles of these important innate mediators. In fact, this meeting is the only international meeting that brings together the world's leading experts on NK and NKT cell biology in a forum that is uniquely devoted to understanding the "crosstalk" between these two innate lymphocyte subsets. This meeting will address many questions related to fundamental mechanisms involved in the activation and regulation of immune responses to infectious pathogens. Moreover, understanding NK and NKT cell biology has broad implications, and therefore multiple, diverse plenary sessions will be devoted to the study of these two cell types, encompassing everything from signaling and development to whole organ studies of immune responses in the context of infection, autoimmunity and cancer.

描述(由申请人提供)： 摘要 PI：Robertson，Andrew D项目：1R13AI091292-01标题：NK和NKT细胞生物学：先天反应的特异性和冗余性登录号：3255538 = 注意：此摘要摘自应用程序，未经SRA校对。如果应用程序扫描过程有问题，提取的文本可能不正确或不完整。 = 该提案请求支持将于2011年1月9日至14日在科罗拉多州布雷肯里奇举行的题为NK和NKT细胞生物学：先天反应的特异性和冗余性的Keystone研讨会，该会议由James P.Di Santo、Eleanor M.Riley和Mitchell Kronenberg组织。在过去的十年里，我们关于先天免疫的知识基础呈爆炸式增长，我们对先天免疫机制的理解很快就会影响到临床。然而，关于NK细胞和NKT细胞如何形成先天和获得性免疫反应，我们仍然有很多需要了解的地方。这次会议将通过聚集NK和NKT细胞专家来讨论与这两个专门的天然淋巴细胞群体的生物学作用有关的问题，讨论他们在以下主题上的最新前沿成果：NK/NKT的发展；NK/NKT细胞的配体识别；NK/NKT的激活和“串扰”；以及NK/NKT细胞在炎症疾病、感染和癌症中作为免疫反应的效应者和调节者的作用。NK细胞和NKT细胞生物学家之间的这种对峙应该会促进一个关于NK/NKT细胞反应的特异性和冗余性的讨论和辩论的活跃论坛，并有望导致新的合作，以帮助我们加深对这些重要的先天介质的生物学作用的理解。事实上，这次会议是唯一一次将世界领先的NK和NKT细胞生物学专家聚集在一个论坛上的国际会议，该论坛专门致力于了解这两个先天淋巴细胞亚群之间的“串扰”。这次会议将讨论与激活和调节对感染病原体的免疫反应有关的基本机制的许多问题。此外，了解NK和NKT细胞生物学具有广泛的意义，因此，多个不同的全体会议将致力于这两种细胞类型的研究，包括从信号和发育到感染、自身免疫和癌症背景下的免疫反应的整个器官研究。