Hematopoiesis

描述(由申请人提供)：本提案请求支持由David Traver、Amy J.Wagers和Emmanuelle Passegui组织的题为造血的Keystone研讨会，该会议将于2011年3月27日至4月1日在蒙大拿州的Big Sky举行。作为发育和再生生物学的典范，对造血系统的研究对于建立生长因子信号、转录调控、器官构型和干细胞生物学的基本原理至关重要。现在，随着新的和新兴的知识，我们开始发展一个真正的分子理解血细胞是如何产生和维持的，以及它们的功能如何在造血缺陷和恶性肿瘤的背景下受到干扰。此外，复杂的胚胎学研究最终证明了发育中的生物体中存在双潜能的血源性内皮细胞，体内成像和细胞鉴定策略的惊人技术进步为我们提供了第一个直接原位可视化血细胞形成的方法。所有这些都表明了细胞迁移和与离散生态位相互作用在细胞命运和功能方向上的关键重要性。最后，当转向血液疾病的研究时，这些工具为调节衰老和恶性肿瘤期间的造血(Dys)功能的微环境控制提供了意想不到的见解。鉴于这些令人振奋的发展，很明显，现在是再次聚集造血研究人员以促进和加速新知识和新想法交流的时候了。这次会议将包括一组不同的科学家，他们用新技术和互补的模型系统研究造血。所有职业阶段的演讲者都已被邀请，演讲将集中于当前的发现、新出现的机会和该领域面临的直接挑战。我们期待这次会议成为发展新想法和合作的催化剂，并加强和鼓励创造性和互动性科学，这将继续推动这一重要研究领域的发现。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Hematopoiesis, organized by David Traver, Amy J. Wagers and Emmanuelle Passegui, which will be held in Big Sky, Montana from March 27 - April 1, 2011. As a paradigmatic model of developmental and regenerative biology, studies of the hematopoietic system have been critical in establishing fundamental principles in growth factor signaling, transcriptional regulation, organ patterning and stem cell biology. Now, with new and emerging knowledge, we are beginning to develop a true molecular understanding of the mechanisms by which blood cells are created and maintained, and how their function may be perturbed in the context of hematopoietic deficiency and malignancy. In addition, sophisticated embryological studies have finally documented the existence of bipotential hemogenic endothelium in developing organisms, and striking technological advances in in vivo imaging and cell identification strategies have provided our first direct visualization of blood cell formation in situ. All of this has indicated the key importance of cell migration and interaction with discrete niches in the direction of cell fate and function. Finally, when turned to the study of blood diseases, these tools have provided unexpected insights into the microenvironmental controls that regulate hematopoietic (dys)function during aging and malignancy. In light of these exciting developments, it is clear that the time has come to again bring together hematopoiesis researchers to facilitate and accelerate the exchange of new knowledge and ideas. This meeting will include a diverse group of scientists studying hematopoiesis with new technologies and complementary model systems. Speakers have been invited from all career stages, and talks will focus on current findings, emerging opportunities, and immediate challenges within the field. We expect this meeting to serve as a catalyst to develop new ideas and collaborations, and to enhance and encourage the creative and interactive science that will continue to push forward discoveries in this important area of research.