Mechanisms of Cardiac Growth, Death and Regeneration

心脏生长、死亡和再生的机制

• 批准号: 8056942
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.38万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8056942
• 关键词: Academia; Address; Apoptosis; Area; Basic Science; Biology; Biotechnology; Cardiac; Cardiac Myocytes; Cardiology; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cell Death; Cells; Cessation of life; Clinical; Colorado; Decision Making; Disease; Functional disorder; Goals; Growth; Health; Heart; Heart Hypertrophy; Heart failure; Hypertrophy; Individual; Learning; Mediating; Molecular; Myocardial Infarction; Natural regeneration; Necrosis; Outcome; Participant; Pathway interactions; Population; Positioning Attribute; Postdoctoral Fellow; Request for Proposals; Research; Research Personnel; Signal Pathway; Signal Transduction; Staging; Stem cells; Structure; Students; Syndrome; Therapeutic; Tissue Engineering; United States; abstracting; base; bench to bedside; career; cell growth; experience; graduate student; human disease; lectures; meetings; mortality; novel therapeutics; posters; progenitor; programs; receptor; repaired; response; sensor; stem cell biology; symposium

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Mechanisms of Cardiac Growth, Death and Regeneration, organized by Richard N. Kitsis, Ivor J. Benjamin and Charles E. Murry, which will be held in Keystone, Colorado from February 22 - 27, 2011. Cardiovascular disease is the major cause of death in the world. Although advances have been made in our understanding of cardiac biology and pathobiology, significant conceptual and practical gaps remain. This meeting - in combination with a concurrent meeting on Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics - will address these gaps by focusing on fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human disease. These paired cardiovascular-centric meetings bring diverse areas under an umbrella focused on the heart in health and disease. While primarily basic science-based, each meeting uniquely incorporates bench-to-bedside novel therapeutics sessions with the goal of broadening the attraction of this meeting to investigators from academia, pharma, biotechnology, and in the clinical enterprise. Both meetings deal with hypertrophy and heart failure, and disease. The focus of the Mechanisms of Cardiac Growth, Death and Regeneration meeting includes stem cells and stem cell/tissue engineering, and therefore this meeting occupies a unique position with respect to cardiac stem cell biology meetings. PUBLIC HEALTH RELEVANCE: Myocardial infarction and heart failure are the two major cardiac syndromes that are the most common causes of mortality in the United States and the world. The Keystone Symposia meeting on Mechanisms of Cardiac Growth, Death and Regeneration addresses the molecular underpinnings of the most fundamental decisions made by cardiac cells: a) to differentiate from their progenitors; b) to grow; or c) to survive or to die. This meeting, held in tandem with a meeting on Molecular Cardiology, will involve scientific questions relevant both to the cardiovascular system and stem cell biology as a whole.

描述（由申请人提供）：本提案请求支持由Richard N. Kitsis，Ivor J. Benjamin和Charles E.默里，这将是在基斯通，科罗拉多从2011年2月22日至27日举行。心血管疾病是世界上主要的死亡原因。虽然我们对心脏生物学和病理生物学的理解已经取得了进展，但仍然存在重大的概念和实践差距。本次会议-结合分子心脏病学：疾病机制和实验治疗学的同期会议-将通过关注调节心脏结构，功能和修复的基本机制以及它们与人类疾病的关系来解决这些差距。这些成对的以心血管为中心的会议将不同的领域集中在健康和疾病的心脏上。虽然主要以基础科学为基础，但每次会议都独特地结合了从实验室到床边的新颖疗法会议，目的是扩大这次会议对学术界，制药，生物技术和临床企业研究人员的吸引力。这两个会议都涉及肥大和心力衰竭以及疾病。心脏生长、死亡和再生机制会议的重点包括干细胞和干细胞/组织工程，因此该会议在心脏干细胞生物学会议中占有独特的地位。 公共卫生相关性：心肌梗死和心力衰竭是两种主要的心脏综合征，是美国和世界上最常见的死亡原因。关于心脏生长、死亡和再生机制的Keystone研讨会会议讨论了心脏细胞做出的最基本决定的分子基础：a）与其祖细胞分化; B）生长;或c）生存或死亡。这次会议与分子心脏病学会议同时举行，将涉及与心血管系统和干细胞生物学相关的科学问题。