Immunity in the Respiratory Tract: Challenges of the Lung Environment

描述（由申请人提供）： 该提案要求支持由大卫L。Woodland，Liise-anne Pirofski和艾伦G. Harmsen，将于2011年2月26日至3月3日在加拿大不列颠哥伦比亚省的温哥华举行。最近，关于肺部炎症、免疫和免疫病理学调节的信息激增。尽管取得了这些进展，但我们仍然对这些反应如何与肺部环境相关，或者它们如何以及为什么转化为有益或有害的影响，健康或疾病只有初步的了解。本次会议将汇集过敏症专家，免疫学家，微生物学家和疫苗学家，在肺部生物学的背景下讨论肺部炎症和免疫，并在此基础上促进改进疫苗和治疗干预措施的发展炎症条件和影响肺部的传染病。全体会议上的专家会谈将介绍该领域的最新研究。我们预计，这次会议将大大促进我们对呼吸免疫的理解。此外，跨学科互动的机会将大大提高粘液生物学同期会议：耐受性和免疫力之间的良好平衡，将与本次会议分享一个主题演讲和两个全体会议。 项目叙述： 肺炎是全世界五岁以下儿童的主要杀手，也是发达国家和发展中国家成人发病和死亡的重要原因。有鉴于此，呼吸道免疫的关键研讨会会议的重要性：肺部环境的挑战不能被高估：来自不同背景和环境的领先科学家将参与关于疾病的关键讨论，以及了解肺部免疫和控制肺部炎症的挑战。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Immunity in the Respiratory Tract: Challenges of the Lung Environment, organized by David L. Woodland, Liise-anne Pirofski and Allen G. Harmsen, which will be held in Vancouver, British Columbia, Canada from February 26 - March 3, 2011. Recently, there has been an explosion in information about the regulation of inflammation, immunity, and immunopathology in the lung. Despite these advances, we still have only a rudimentary understanding of how these responses relate to the lung environment or how and why they translate into beneficial or detrimental effects, health or disease. This meeting will bring together allergists, immunologists, microbiologists and vaccinologists to discuss pulmonary inflammation and immunity in the context of lung biology, and to build on this understanding to promote development of improved vaccines and therapeutic interventions for inflammatory conditions and infectious diseases that affect the lungs. Expert talks in plenary sessions will present the latest research in the field. We anticipate that the meeting will considerably advance our understanding of respiratory immunity. Moreover, opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mucosal Biology: A Fine Balance between Tolerance and Immunity, which will share a keynote address and two plenary sessions with this meeting. Project Narrative: Pneumonia is a leading killer of children worldwide under the age of five years, as well as an important cause of morbidity and mortality in adults in the developed and developing world. In light of this, the importance of the Keystone Symposia meeting on Immunity in the Respiratory Tract: Challenges of the Lung Environment cannot be overestimated: leading scientists from diverse backgrounds and settings will engage in critical discussions about the disease and challenges to understanding immunity in the lung and controlling lung inflammation.