Immunity in the Respiratory Tract: Challenges of the Lung Environment

呼吸道免疫：肺部环境的挑战

• 批准号: 8057229
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8057229
• 关键词: Accounting; Address; Adult; Affect; Age; Biology; British Columbia; Canada; Child; Communicable Diseases; Communities; Complex; Development; Disease; Environment; Equilibrium; Explosion; Goals; Health; Host Defense; Immune response; Immunity; Immunologist; Immunology; Immunotherapeutic agent; Immunotherapy; Individual; Infection; Inflammation; Inflammatory; Inflammatory Response; Lead; Light; Lung; Lung Inflammation; Microbe; Morbidity - disease rate; Natural Immunity; Organ; Outcome; Participant; Pneumonia; Prevention approach; Recovery; Regulation; Request for Proposals; Research; Research Personnel; Respiratory System; Respiratory tract structure; Scientist; Structure-Activity Relationship; Therapeutic Intervention; Translating; Vaccines; adaptive immunity; design; immunopathology; improved; lectures; meetings; microbial; mortality; novel strategies; pathogen; respiratory; response; symposium

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Immunity in the Respiratory Tract: Challenges of the Lung Environment, organized by David L. Woodland, Liise-anne Pirofski and Allen G. Harmsen, which will be held in Vancouver, British Columbia, Canada from February 26 - March 3, 2011. Recently, there has been an explosion in information about the regulation of inflammation, immunity, and immunopathology in the lung. Despite these advances, we still have only a rudimentary understanding of how these responses relate to the lung environment or how and why they translate into beneficial or detrimental effects, health or disease. This meeting will bring together allergists, immunologists, microbiologists and vaccinologists to discuss pulmonary inflammation and immunity in the context of lung biology, and to build on this understanding to promote development of improved vaccines and therapeutic interventions for inflammatory conditions and infectious diseases that affect the lungs. Expert talks in plenary sessions will present the latest research in the field. We anticipate that the meeting will considerably advance our understanding of respiratory immunity. Moreover, opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mucosal Biology: A Fine Balance between Tolerance and Immunity, which will share a keynote address and two plenary sessions with this meeting. Project Narrative: Pneumonia is a leading killer of children worldwide under the age of five years, as well as an important cause of morbidity and mortality in adults in the developed and developing world. In light of this, the importance of the Keystone Symposia meeting on Immunity in the Respiratory Tract: Challenges of the Lung Environment cannot be overestimated: leading scientists from diverse backgrounds and settings will engage in critical discussions about the disease and challenges to understanding immunity in the lung and controlling lung inflammation.

描述（由申请人提供）： 该提议要求支持呼吸道中的题为“免疫力：肺部环境的挑战”，由戴维·L·伍德兰（David L.肺中的免疫病理学。尽管取得了这些进步，但我们仍然对这些反应与肺部环境有何关系，以及它们如何转化为有益或有害影响，健康或疾病的方式以及为什么它们有基本的理解。这次会议将汇集过敏症分子，免疫学家，微生物学家和疫苗科学家，讨论肺部生物学背景下的肺部炎症和免疫力，并建立在这种理解的基础上，以促进改善疫苗和治疗性干预措施的炎性疾病和影响肺部的感染性疾病。全体会议的专家会议将介绍该领域的最新研究。我们预计会议将大大提高我们对呼吸免疫的理解。此外，跨学科互动的机会将通过粘膜生物学的并发会议大大提高：宽容和免疫之间的良好平衡将在本次会议上共享主题演讲和两次全体会议。 项目叙述： 肺炎是全球五岁以下儿童的主要杀手，也是发达国家和发展中国家成人发病率和死亡率的重要原因。鉴于这种情况，基斯通研讨会在呼吸道中的免疫力会议的重要性：肺部环境的挑战不能被高估：来自不同背景和环境的领先科学家将对了解肺部免疫和控制肺部炎症的疾病和挑战进行批判性讨论。