Optical Biology Core

光学生物学。 该中心的光学生物学核心有一个 出现在四个地点。每一个都已充当 UCI，BUT中心的光学生物学资源 资金将允许购买更多 与中心目标有关的设备(见 预算和理由)，并将提供更多资金 协调使用、共享信息和 对更广泛的研究界的影响。四个 地点：1)荧光实验室 动力学(LFD)，由恩里科·格拉顿执导；2) 贝克曼激光研究所(BLI)，由布鲁斯执导 特伦贝格大学光学生物学中心(OBC) 发育生物学中心，由拉里指导 以及4)马什大学生物物理实验室 《机动运输》(MDT)，史蒂文执导 恶心。 每个设施都提供独特的设备和 在光学检测、测量、 以及对空间动态过程的操纵。AS 在前面关于外展的部分中提到， LFD和BLI是P41资助的积极中心 参与开发和传播 新技术。LFD重点介绍了以下方面的进展 相关光谱学和粒子跟踪。这个 BLI专注于探测的新光学方法 生物物质的组织尺度特性。在……里面 此外，MDT还集成了光钳、力 测量、粒子跟踪和图像分析。 OBC不直接负责开发新的 技术，而是提供访问和 在广泛的生物应用方面的培训 共聚焦荧光显微镜和(例如，涉及 光电转换探头、FCS、FRET等)。这个 OBC还分发季度时事通讯，以保持 调查人员获知最新发展 荧光显微镜。其中的每一个设施 拥有独特的硬件和软件可用 供中心成员及其访客使用。 这一核心在教育中也扮演着重要的角色。 和培训，将在下一节讨论。

Optical Biology. The optical biology core of the Center has a presence in four locations. Each already serves as a resource for optical biology at UCI, but Center funding will allow the purchase of additional equipment related to the aims of the Center (see budget and justification), and will provide for greater coordination of use, sharing of information, and impact on the wider research community. The four locations are 1) the Laboratory for Fluorescence Dynamics (LFD), directed by Enrico Gratton; 2) The Beckman Laser Institute (BLI), directed by Bruce Tromberg; 3) The Optical Biology Center (OBC) of the Developmental Biology Center, directed by Larry Marsh; and 4) The Laboratory for the Biophysics of Motor-Driven Transport (MDT), directed by Steven Gross. Each facility provides unique equipment and expertise for the optical detection, measurement, and manipulation of spatially-dynamic processes. As previously mentioned in the section on outreach, the LFD and BLI are P41-funded centers actively engaged in the development and dissemination of new technologies. The LFD focuses on advances in correlation spectroscopy and particle tracking. The BLI focuses on novel optical methods for probing tissue-scale properties of biological matter. In addition, the MDT integrates optical tweezers, force measurements, particle tracking and image analysis. The OBC is not directly charged with developing new technology, but rather with providing access and training in a wide variety of biological applications of confocal fluorescence microscopy and (e.g. involving photoconvertible probes, FCS, FRET, etc.). The OBC also distributes a quarterly newsletter to keep investigators informed of the latest developments in fluorescence microscopy. Each of these facilities possesses unique hardware and software available for use by the Center's members and its visitors. This core also plays an important role in education and training, as discussed in the next section.