CSHL 2015 Systems Biology Conference in Puerto Rico

 描述(申请人提供)：细胞如何控制其基因组的表达是生物学中的一个基本问题。自从基因和DNA的双链螺旋结构被发现以来，人们一直在不断地研究这个问题。已经有了许多伟大的发现，包括制造转录本的核机器，以及用于控制基因表达的多种类型的DNA序列。尽管做出了这些努力，但与全球基因表达调控相关的许多根本问题仍然没有得到解决。例如，尽管已有许多完整的基因组序列，但人类基因组中大多数基因的转录调控序列和调控蛋白仍然定义不清。显然，需要实验生物学家和计算生物学家之间的有效合作，才能解决基因调控的复杂问题。因此，我们建议主办一次会议，以便能够自由地跨学科交流现有的想法和专门知识。希望这次会议将提供一个 建立新的合作机制，以及讨论新的实验和计算方法的论坛。这项提案寻求美国国立卫生研究院的资助，以支持年轻科学家(研究生、博士后研究员和新教师)积极参加之前在冷泉港实验室举行的系统生物学系列科学会议的第十次会议。2015年的会议将由冷泉港实验室管理，但在波多黎各精心挑选的场外地点举行。这次会议旨在促进对真核生物中复杂转录网络的组织和控制感兴趣的实验者和计算生物学家之间的跨学科思想和专业交流。拟议的会议将集中讨论几个关键主题：转录调控网络；顺式调控逻辑；染色质和表观遗传学；转录后调控；变异和进化；新兴技术；发育网络和细胞反应。一组杰出的特邀演讲者以及从提交的摘要中挑选出来的演讲者将作口头陈述。选定的演讲者将包括研究生、博士后研究员和初级教职员工，旨在最大限度地纳入年轻研究人员。特别重要的是两个海报会议，许多与会者可以在有利于非正式讨论的气氛中介绍他们的工作。会议规模适中，我们预计将有大约250人参加，其中绝大多数人将展示海报或发表演讲。我们还预期，本次会议将邀请波多黎各学术界的当地科学家参加。这项提议寻求资金，以支持早期职业调查人员参加这一重要会议。

 DESCRIPTION (provided by applicant): How cells control the expression of their genomes is a fundamental problem in biology. Ever since the discovery of the genes and the double strand helix structure of the DNA, there have been continuous investigations into this problem. Many great discoveries have been made, including the nuclear machineries that make transcripts as well as the many types of DNA sequence that serve to control gene expression. Despite these efforts, many fundamental issues associated with the global regulation of gene expression remain unresolved. For example, the transcriptional regulatory sequences and the regulatory proteins for most genes in the human genome are still poorly defined, despite the availability of many complete genome sequences. It is clear that effective collaborations between experimental and computational biologists will be required to come to grips with the complex problems of gene regulation. Thus we propose to host a meeting to permit a free cross-disciplinary exchange of existing ideas and expertise. It is hoped that this meeting will provide a mechanism for the establishment of new collaborations, and a forum for discussing new experimental and computational approaches. This proposal seeks National Institutes of Health funding to support the active participation of young scientists (graduate students, postdoctoral fellows and new faculty) at the tenth in a series of scientific meetings on systems biology, which have previously been held at Cold Spring Harbor Laboratory. The 2015 conference will be managed by Cold Spring Harbor Laboratory but held in a carefully selected offsite location in Puerto Rico. The meeting is intended to foster cross-disciplinary exchange of ideas and expertise between experimentalists and computational biologists interested in the organization and control of complex transcription networks in eukaryotes. The proposed meeting will focus on several key themes: Transcriptional Regulatory Networks; Cis-Regulatory Logic; Chromatin & Epigenetics; Post-transcriptional Regulation; Variation & Evolution; Emerging Technologies; Developmental Networks & Cellular Responses. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size and we expect about 250 people to attend, the vast majority of whom will be presenting a poster or talk. We also anticipate that this meeting will engage the participation of local scientists from the academic community in Puerto Rico. This proposal seeks funding to support the participation of early career investigators in this important meeting.