Gram-Negative Resistance

革兰氏阴性菌耐药性

• 批准号: 8831854
• 负责人: DAVID L. WOODLAND
• 金额: $ 0.3万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-18 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8831854
• 关键词: Academia; Acute; Address; Adult; Anti-Bacterial Agents; Antibiotic Resistance; Antibiotics; California; Cessation of life; Chemotherapy-Oncologic Procedure; Childhood; Cities; Clinic; Clinical Treatment; Collaborations; Communicable Diseases; Complex; Development; Diagnostic; Discipline; Drug resistance; Effectiveness; Explosion; Failure; Government; Gram-Negative Bacteria; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Health; Healthcare; Human; Industry; Infection; Knowledge; Learning; Left; Life Expectancy; Medical; Medicine; Methodology; Multi-Drug Resistance; National Institute of Allergy and Infectious Disease; Organ Transplantation; Outcome; Penicillins; Pharmaceutical Preparations; Physicians; Policies; Research; Research Personnel; Resistance; Resolution; Route; Scientist; Solutions; Therapeutic; Thinking; Time; Training; Work; antimicrobial; anxious; clinical practice; design; drug development; drug discovery; experience; improved; innovation; meetings; next generation; novel; novel vaccines; pathogen; posters; prospective; public health relevance; stem; success; symposium

 DESCRIPTION (provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Gram-Negative Resistance, organized by Robert E.W. Hancock and Eric D. Brown. The meeting will be held in Tahoe City, California from March 29 - April 2, 2015. The antibiotic era, stemming from the deployment of penicillin, introduced arguably the most successful medicines of all time, impacting dramatically on life expectancy by decreasing childhood and adult deaths from infections, and enabling complex surgeries, transplantations and cancer chemotherapy. However the therapy of infectious diseases is now under severe threat. There has been an explosion of resistance to antibiotics, whereby our entire arsenal of antibiotics is gradually losing effectiveness. This is particularly acute for gram-negative bacteri since there are few new antibiotics or strategies in the development pipeline. This Keystone Symposia meeting will address the major issues and potential solutions to this crisis. The issues associated with gram-negative resistance, and the design of effective therapeutics, are different and more complicated than those associated with the other major division of bacteria (gram-positives). Consistent with the most recent antibiotics are active against the latter class leaving academic and company researchers and physicians to wonder where the next generation of treatments will come from. For this reason, it is essential that these issues are discussed as a distinct problem that has the potential to unravel human medical successes. This meeting will bring together diverse researchers from disciplines ranging from discovery research to drug development and clinical treatment to discuss strategies for addressing this critical issue and proposing routes for innovative solutions. Support of this conference is consistent with the statement that "Discoveries made by NIAID researchers help inform the development of new vaccines, therapeutics, and diagnostics that improve human health".

 描述（由申请人提供）：请求支持由Robert E.W.汉考克和埃里克D.布朗会议将于2015年3月29日至4月2日在加州的太浩城举行。抗生素时代，源于青霉素的部署，引入了可以说是有史以来最成功的药物，通过减少儿童和成人因感染而死亡，并实现复杂的手术，移植和癌症化疗，对预期寿命产生了巨大影响。然而，传染病的治疗目前正受到严重威胁。对抗生素的耐药性激增，我们的整个抗生素库正在逐渐失去效力。这对于革兰氏阴性杆菌尤其严重，因为在开发管道中几乎没有新的抗生素或策略。本次基石研讨会会议将讨论这场危机的主要问题和潜在解决方案。与革兰氏阴性菌耐药性相关的问题以及有效治疗方法的设计与其他主要细菌（革兰氏阳性菌）相关的问题不同且更复杂。与最近的抗生素一致，它们对后一类离开是有效的。 学术界和公司的研究人员和医生想知道下一代的治疗方法将来自哪里。出于这个原因，必须将这些问题作为一个有可能破坏人类医学成功的独特问题进行讨论。本次会议将汇集来自不同学科的研究人员，从发现研究到药物开发和临床治疗，讨论解决这一关键问题的策略，并提出创新解决方案的路线。对这次会议的支持与“NIAID研究人员的发现有助于为改善人类健康的新疫苗，治疗和诊断的开发提供信息”的声明是一致的。