Manufacturing and testing of graphene-based-FETs biosensors

为了提高乳腺癌肿瘤标志物(生物分子)检测的诊断效率，我们提出了基于石墨烯效应晶体管(FET)的便携式、低成本、用户友好的生物传感器的临床应用。FET生物传感器为癌症的早期检测带来了巨大的希望，这是预防癌症相关死亡的关键策略。 也许生物传感器最有前途的应用是它们在监测和检测与特定疾病相关的特定分子方面的使用，例如在乳腺癌患者的诊断中。由于技术和成本的限制，传统技术的筛查和诊断不允许我们检测大量的生物标记物。蛋白质组学和基因组学的阵列芯片技术通常需要几个阶段的扩增才能进行可靠的分析。这些技术所需的时间和细胞数量被证明是未来分子应用于医学科学的瓶颈。我们在这个项目中提出的传感器将能够在非常少量的溶液(一滴血)的情况下同时检测不同的肿瘤标志物，以实现精确的检测/早期诊断。

We propose manufacturing portable low cost and user friendly biosensors based on graphene-field effect transistors (FET) to improve the diagnostic efficiency of breast cancer tumor marker (biomolecule) detection in clinical applications. FET biosensors hold great promise for early-stage detection of cancer, a strategy crucial to the prevention of cancer related death. Perhaps the most promising application for biosensors is their use in monitoring and detecting specific molecules associated with a particular disease, such as in breast cancer patient diagnostics. Screening and diagnosis by conventional techniques does not allow us a large number of biomarkers to be detected due to technological and cost limitations. Array chip techniques for both proteomics and genomics often require several stages of amplification for reliable analysis. The time and the number of cells needed for these techniques are proving to be bottlenecks for future molecular applications in medical science. Sensors we propose in this project will enable detection of different tumor markers at the same time with very small amount of solution (a drop of blood) for precise detection/early diagnosis.