Acquisition of a 500 MHz NMR Spectrometer

将获得一台500 MHz核磁共振光谱仪，以支持生物化学和化学方面的研究。将支持的项目包括杂环化合物的有机合成，天然产物的物理、合成和有机化学，酶机制，以及肽和蛋白质折叠。现代的一维和二维核磁共振研究方法将利用同核和异核的观测、化学位移相关谱(COSY)、核Overhauser效应相关谱(NOESY)和接力转移光谱。在合成化学中的应用将对整个工业发展特别是生物技术具有长期价值；同样，关于酶机制以及多肽和蛋白质折叠的生物化学研究解决了生物学上感兴趣的主要问题，并将对生物技术和与健康有关的研究产生长期影响。如果没有这种仪器，所提出的一些实验就无法进行；另一些实验只能进行得慢得多。该仪器可以对生物和有机化合物的物理性质进行详细分析，对于在迫在眉睫的基本科学问题上取得进展至关重要。

A 500 MHz NMR Spectrometer will be acquired to support research in biochemistry and chemistry. Among the projects to be supported are organic synthesis of heterocyclic compounds, physical, synthetic and organic chemistry of natural products, enzyme mechanism, and peptide and protein folding. Contemporary research methods in 1D and 2D NMR will be done using observations of homonuclei and heteronuclei, chemical shift correlation spectroscopy (COSY), nuclear Overhauser effect correlation spectroscopy (NOESY), and relay transfer spectroscopy. The applications in synthetic chemistry will be of long-term value to industrial development in general and biotechnology in particular; similarly, the biochemical studies, on enzyme mechanism, and peptide and protein folding, address major problems of biological interest and will have an impact in biotechnology and in the long term in health-related research. Without this instrumentation, some of the experiments proposed could not be carried out; others could be carried out only much much more slowly. The instrumentation allows a detailed analysis of physical properties of biological and organic compounds and is essential for progress on the immediate basic scientific questions.