Defining how signalling pathways cooperate to regulate organ size

器官大小的控制对于器官功能和生物体生存能力至关重要，并且在动物王国中差异很大。该项目旨在了解三个重要的信号通路如何在发育过程中协调调节器官大小，并限制异常生长。通过应用基因组学、遗传学和生物信息学技术，该项目旨在发现一组受不同信号通路调控的核心生长基因，以及抑制这些基因转录以消除缺陷细胞的机制。预期的好处是创造就业机会，对生命的基本原则的新知识和刺激对器官大小控制的新研究。

Control of organ size is essential for organ function and organism viability, and varies greatly across the animal kingdom. This project aims to understand how three important signalling pathways co-ordinately regulate organ size during development and also limit aberrant growth. By applying genomics, genetics and bioinformatics techniques, this project aims to discover a core set of growth genes that are regulated by different signalling pathways and the mechanism by which transcription of these genes is repressed in order to eliminate faulty cells. Intended benefits are creation of jobs, new knowledge on fundamental principles of life and the stimulation of new research into organ size control.