Acquisition of a 500 MHz NMR Spectrometer

化学研究仪器计划的这一奖项将帮助伦斯勒理工学院化学系获得一台500 MHz核磁共振光谱仪，该光谱仪将用于以下化学领域的研究调查：1)蛋白质(内皮素、丙氨菌素、革兰西丁和溶菌酶的离子结合部位)，2)药物与模型寡核苷酸的相互作用，3)自组装无机双螺旋化合物；4)细胞膜上的离子通道；5)聚醚抗生素；6)具有生物活性的有机分子的对映选择性合成。这十个小用户的应用包括胆固醇生物合成抑制剂的研究，糖苷抗生素的研究，以及天然和合成聚合物的结构和动力学表征。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物和催化等领域以及生物学中都是有用的。

This award from the Chemistry Research Instrumentation Program will help the Department of Chemistry at Rensselaer Polytech Institute acquire a 500 MHz NMR spectrometer which will be used in research investigations in the following areas of chemistry: 1) proteins (endothelin, alamethicin, gramicidin and ion-binding sites of lysozyme), 2) drug interactions with model oligonucleotides, 3) self-assembled inorganic double helicates 4) ion channels in cell membranes 5) polyether antibiotics and 6) enantioselective syntheses of organic molecules with biological activity. The applications of the ten minor users include the study of inhibitors of cholesterol biosynthesis, glycoside antibiotics, and characterization of the structure and dynamics of natural and synthetic polymers. Nuclear Magnetic Resonance (NMR) Spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.